Phenytoin Sodium Tablets

This product is an antiepileptic drug and antiarrhythmic drug. The therapeutic dose does not cause sedation and hypnosis. 1 Animal experiments have shown that this product has a selective antagonistic effect on the tonic phase of super-strong electric shock and convulsion, but is ineffective or even aggravates the spasm phase. Therefore, it is effective for grand mal epileptic seizures, but ineffective for absence seizures. Its antiepileptic mechanism has not yet been elucidated. It is generally believed that it increases the outflow of sodium ions from cells and reduces the inflow of sodium ions, thereby stabilizing the nerve cell membrane, raising the excitation threshold, and reducing the spread of high-frequency discharges in the lesions. 2 In addition, this product shortens the action potential interval and the effective refractory period, and can also inhibit the influx of calcium ions, reduce myocardial automaticity, inhibit the sympathetic center, and have an inhibitory effect on the ectopic rhythm points of the atria and ventricles, increasing the thresholds for atrial fibrillation and ventricular fibrillation. 3 Its stability

The main ingredient of this product is phenytoin sodium, and its chemical name is: 5,5-diphenyl-2,4-imidazolidinedione sodium salt

This product is white tablets or film-coated tablets.

It is suitable for the treatment of generalized tonic-clonic seizures, complex partial seizures (psychomotor seizures, temporal lobe epilepsy), simple partial seizures (localized seizures) and status epilepticus. It can also be used to treat trigeminal neuralgia, recessive dystrophic epidermolysis bullosa, paroxysmal choreoathetosis, paroxysmal control disorders (including behavioral disorders such as anger, anxiety and insomnia due to excessive excitement), myotonia and cardiac conduction disorders in case of overdose of tricyclic antidepressants. This product is also suitable for ventricular and supraventricular arrhythmias caused by digitalis poisoning, and has poor efficacy on arrhythmias caused by various other reasons.

Common dosage for anti-epileptic drugs in adults: 250-300 mg per day, 100 mg at the beginning, twice a day, increase to 250-300 mg within 1-3 weeks, divided into three times for oral administration, the maximum dose is 300 mg once, 500 mg per day. Due to individual differences and saturation pharmacokinetic characteristics, medication needs to be individualized. After the seizures are controlled and the blood drug concentration reaches a steady state, a long-acting (controlled-release) preparation can be used instead, taken all at once. If the seizures are frequent, 12-15 mg/kg can be taken according to body weight, divided into 2-3 times, once every 6 hours, and 100 mg (or 1.5-2 mg/kg according to body weight) can be given from the next day, 3 times a day until the appropriate dose is adjusted. Common dosage for children: Start with 5 mg/kg per day, divided into 2-3 times, adjust as needed, with no more than 250 mg per day.

This product has few side effects, and gingival hyperplasia is common. The incidence rate is high in children, so oral hygiene and gingival massage should be strengthened. After long-term use or when the blood concentration reaches 30mu;g/ml, it may cause nausea, vomiting and even gastritis, which can be alleviated by taking it after meals. Adverse reactions of the nervous system are related to the dose, and dizziness and headache are common. In severe cases, it can cause nystagmus, ataxia, slurred speech and confusion, which can disappear by adjusting the dose or stopping the drug; less common adverse reactions of the nervous system include dizziness, insomnia, transient nervousness, convulsions, chorea, dystonia, tremor, flapping tremor, etc. It can affect the hematopoietic system, causing granulocytopenia and thrombocytopenia, and rare aplastic anemia; megaloblastic anemia is common, which can be prevented and treated with folic acid and vitamin B12. It can cause allergic reactions, common rash with high fever, and rare severe skin reactions.

Contraindications: Patients with a history of allergy to hydantoins or those with heart function impairment such as Ass syndrome, II-III degree atrioventricular block, sinus node block, sinus bradycardia, etc.

1. Long-term use of acetaminophen in patients may increase the risk of liver poisoning and reduce the efficacy of this product. 2. It is a liver enzyme inducer. When used in combination with corticosteroids, digitalis (including digoxin), oral contraceptives, cyclosporine, estrogen, levodopa, quinidine, oxytetracycline or tricyclic antidepressants, the effects of these drugs may be reduced. 3. Long-term drinking can reduce the concentration and efficacy of this product, but drinking a lot of alcohol while taking the medicine can increase the blood concentration; combined use with chloramphenicol, isoniazid, phenylbutazone, and sulfonamides may reduce the metabolism of this product and increase the blood concentration, increasing the toxicity of this product; combined with anticoagulants, the anticoagulant effect will increase initially, but it will decrease with continued use. 4. When used with drugs containing magnesium, aluminum or

Keep away from light and store in airtight container.

100mg

China Resources Double-Crane Pharmaceutical Co., Ltd.

• Founded in:

  1997-05-16

• Address:

  No. 1, Lize East 2nd Road, Wangjing, Chaoyang District, Beijing

• Tax NO.:

  91110000633796475U

• Registered Funds:

  1,038,836,522 yuan

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