Chlorpromazine Hydrochloride Injection

This product is a phenothiazine antipsychotic, and its mechanism of action is mainly related to its blocking of dopamine receptors (DA2) in the mesolimbic system and mesocortical pathways. It has a blocking effect on dopamine (DA1) receptors, 5-hydroxytryptamine receptors, M-type acetylcholine receptors, and α-adrenaline receptors, and has a wide range of effects. In addition, this product can inhibit the dopamine receptors in the medulla oblongata emetic chemoreceptor area at low doses, and directly inhibit the vomiting center at high doses, producing a strong antiemetic effect. It inhibits the body temperature regulation center and lowers the body temperature. The body temperature can change with changes in the external environment. It blocks the action of peripheral α-adrenaline receptors, dilates blood vessels, causes a drop in blood pressure, and also has a certain effect on the endocrine system.

The main ingredient of this product is chlorpromazine hydrochloride, and its chemical name is: N,N-dimethyl-2-chloro-10H-phenothiazine-10-propylamine hydrochloride.

This product is a colorless or almost colorless clear liquid.

1. It has a good effect on positive symptoms such as excitement, agitation, hallucination, delusion, thinking disorder and behavioral disorder. It is used for schizophrenia, mania or other psychotic disorders. 2. It can stop vomiting, vomiting or intractable hiccups caused by various reasons.

For schizophrenia or mania, intramuscular injection: 25~50mg once, twice a day, change to oral administration after the patient cooperates. Intravenous drip: start with a small dose, 25~50mg diluted in 500ml glucose sodium chloride injection and slowly drip intravenously, once a day, slowly increase 25~50mg every 1~2 days, and the therapeutic dose is 100~200mg per day. Intravenous push is not suitable.

1 Common symptoms include dry mouth, upper abdominal discomfort, lack of appetite, fatigue and drowsiness. 2 May cause postural hypotension, palpitations or electrocardiogram changes. 3 Extrapyramidal reactions may occur, such as tremor, rigidity, drooling, bradykinesia, akathisia, and acute dystonia. 4 Long-term and large-scale use of the drug may cause tardive dyskinesia. 5 May cause an increase in plasma prolactin concentrations, and possible related symptoms include: galactorrhea, gynecomastia, menstrual disorders, and amenorrhea. 6 May cause local redness, swelling, pain, and nodules at the injection site. 7 May cause toxic liver damage or obstructive jaundice. 8

Patients with basal ganglia lesions, Parkinson's disease, Parkinson's syndrome, bone marrow suppression, glaucoma, coma and allergy to phenothiazines.

1. When this product is used in combination with ethanol or other central nervous system depressants, the central depressant effect is enhanced. 2. When this product is used in combination with antihypertensive drugs, it is easy to cause postural hypotension. 3. When this product is used in combination with sultopride, there is a risk of ventricular arrhythmia, and in severe cases, it can cause torsade de pointes arrhythmia. 4. When this product is used in combination with atropine drugs, the adverse reactions are enhanced. 5. When this product is used in combination with lithium carbonate, it can cause an increase in blood lithium concentration. 6. Antacids can reduce the absorption of this product, and phenobarbital can accelerate its excretion, thereby weakening its antipsychotic effect. 7. This product is combined with monoamine oxidase inhibitors and tricyclic antipsychotics.

Keep away from light and store in a sealed container.

1ml:25mg

Yabang Pharmaceutical Co., Ltd.

• Founded in:

  2010-07-22

• Address:

  No. 66, Changhong West Road, Wujin Economic Development Zone, Changzhou

• Tax NO.:

  91320400559287372K

• Registered Funds:

  300 million yuan

• Email:

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