Sodium Bicarbonate Injection

(1) Treating metabolic acidosis: This product increases the concentration of carbonate in plasma, neutralizes hydrogen ions, and thus corrects acidosis; (2) Alkalinizing urine: As the concentration of carbonate in urine increases, the pH value increases, making it difficult for uric acid, sulfonamide drugs, and hemoglobin to form crystals or aggregate in urine; (3) Reducing acid: Oral administration can quickly neutralize or buffer gastric acid without directly affecting gastric acid secretion. As a result, the pH in the stomach increases rapidly, alleviating the symptoms caused by high gastric acid.

The chemical name of this product is: sodium bicarbonate. The main ingredients of this product are: 50g of sodium bicarbonate (NaHCO3) per 100ml. Structural formula: NaHCO3, molecular formula: NaHCO3, molecular weight: 84.01.

This product is a colorless clear liquid.

1 Treatment of metabolic acidosis: For the treatment of mild to moderate metabolic acidosis, oral administration is preferred. Severe metabolic acidosis should be treated by intravenous drip, such as severe kidney disease, circulatory failure, cardiopulmonary resuscitation, extracorporeal circulation, severe primary lactic acidosis, diabetic ketoacidosis, etc. 2 Alkalinize urine: used for the prevention of uric acid kidney stones, reducing the nephrotoxicity of sulfonamide drugs, and preventing hemoglobin from depositing in the renal tubules during acute hemolysis. 3 As an antacid, it treats symptoms caused by excessive gastric acid. 4 Intravenous drip has a non-specific therapeutic effect on certain drug poisonings, such as poisoning by barbiturates, salicylates, and methanol.

1 Metabolic acidosis, intravenous drip, the required dose is calculated according to the following formula: Alkali supplement amount (mmol) = (-2.3 - actual measured BE value) × 0.25 × body weight (kg), or alkali supplement amount (mmol) = normal CO2CP - actual measured CO2CP (mmol) × 0.25 × body weight (kg). Unless the body loses bicarbonate, generally give 1/3 to 1/2 of the calculated dose first, and complete the drip within 4 to 8 hours. 2 During cardiopulmonary resuscitation, the first dose is 1mmol/kg, and the dose is adjusted according to the results of blood gas analysis (each 1g of sodium bicarbonate is equivalent to 12mmol bicarbonate). 3 The following issues should also be noted when using intravenous medication: (1) Intravenous

1. Arrhythmia, muscle cramps, pain, abnormal fatigue and weakness may occur when a large amount of injection is given, mainly due to hypokalemia caused by metabolic alkalosis. 2. Edema, mental symptoms, muscle pain or twitching, slow breathing, bad breath, abnormal fatigue and weakness may occur when the dose is too large or renal insufficiency exists. Mainly caused by metabolic alkalosis. 3. Frequent urination, urgency, persistent headache, loss of appetite, nausea and vomiting, abnormal fatigue and weakness may occur when the dose is too large or renal insufficiency exists. Mainly caused by metabolic alkalosis. 3. Long-term use may cause frequent urination, urgency, persistent headache, loss of appetite, nausea and vomiting, abnormal fatigue and weakness.

1 Metabolic or respiratory alkalosis; 2 Metabolic alkalosis is very likely to occur due to vomiting or continuous gastrointestinal negative pressure suction leading to a large loss of chloride; 3 In the case of hypocalcemia, alkalosis caused by this product may aggravate the symptoms of hypocalcemia; 4 This product is contraindicated for gastric lavage in the case of ingestion of strong acid poisoning, because this product reacts with strong acid to produce a large amount of carbon dioxide, leading to acute gastric dilatation or even gastric rupture.

Precautions for children: For the treatment of acidosis, refer to the adult dose. During cardiopulmonary resuscitation, the first intravenous injection is 1mmol/kg of body weight, and the dosage is adjusted according to the results of blood gas analysis. Precautions for pregnancy and lactation: 1. Long-term or large-scale use can cause metabolic alkalosis, and excessive sodium load can cause edema, etc. Pregnant women should use it with caution. 2. This product can be secreted through breast milk, but there is no relevant information on its effects on infants. Precautions for the elderly: This experiment has not been conducted and there are no reliable references.

(1) When used in combination with adrenocortical hormones (especially those with strong mineralocorticoid effects), adrenocorticotropic hormone, and androgens, hypernatremia and edema are likely to occur. (2) When used in combination with amphetamine and quinidine, the renal excretion of the latter two is reduced, and toxic effects are likely to occur. (3) When used in combination with anticoagulants such as warfarin and M cholinesterase drugs, the absorption of the latter is reduced. (4) When used in combination with calcium-containing drugs, milk and dairy products, milk-alkali syndrome may occur. (5) When used in combination with H2 receptor antagonists such as cimetidine and ranitidine, the absorption of the latter is reduced. (6) When used in combination with potassium-excreting diuretics, the occurrence of hypochloremic alkali syndrome may be increased.

Store in a sealed container (10-30°C). Valid for 24 months.

100 ml: 5 g