Carbamazepine Capsules

This product is an anticonvulsant and antiepileptic drug. The pharmacological effects of carbamazepine are anticonvulsant, antiepileptic, anti-neuropathic pain, anti-manic-depressive, improvement of symptoms of certain mental illnesses, and anti-central diabetes insipidus. The mechanisms of these effects may be: 1. Use-dependent blocking of various Na channels of excitable cell membranes, so it can significantly inhibit the occurrence and spread of abnormal high-frequency discharges. 2. Inhibit T-type calcium channels. 3. Enhance the activity of central noradrenergic nerves. 4. Promote the secretion of antidiuretic hormone (ADH) or increase the sensitivity of effectors to ADH.

The main ingredient of this product is carbamazepine. Its chemical name is 5H-dibenzo[b,f]azepine-5-carboxamide. Molecular formula: C15H12N2O Molecular weight: 236.27

1. Complex partial seizures (also known as psychomotor seizures or temporal lobe epilepsy), generalized tonic-clonic seizures, the above two mixed seizures or other partial or generalized seizures; ineffective for typical or atypical absence seizures, myoclonic or absence tension seizures. 2. Attacks of trigeminal neuralgia and glossopharyngeal neuralgia. It is also used as a long-term preventive medication after the relief of trigeminal neuralgia. It can also be used for tabes dorsalis and multiple sclerosis, diabetic peripheral neuropathy, pain in the affected limbs, post-traumatic neuralgia and post-herpetic neuralgia. 3. Prevention or treatment of manic-depression; it can be used alone or in combination with lithium salts and other antidepressants for manic-depression that is ineffective or intolerant to lithium, antipsychotics, and antidepressants. 4. Central partial diabetes insipidus. It can be used alone or in combination with chlorpropamide or clofibrate. 5.

Common dosage for adults: 1. Anticonvulsant, start with 0.1g once, 2 to 3 times a day; increase by 0.1g per day after the second day until the effect is seen; the maintenance dose is adjusted to the lowest effective dose, taken in divided doses; pay attention to individualization, the maximum daily dose should not exceed 1.2g. 2. Analgesia, start with 0.1g once, 2 times a day; increase by 0.1 to 0.2g every other day after the second day until the pain is relieved, the maintenance dose is 0.4 to 0.8g per day, taken in divided doses; the maximum daily dose should not exceed 1.2g. 3. Diabetes insipidus, 0.3 to 0.6g per day when used alone. If used in combination with other antidiuretics, 0.2 to 0.4g per day, taken in 3 times. 4. Anti-mania or antipsychotic, start with 0.2 to 0.4g per day, gradually increase to a maximum of 1.6g per week, divided into 3 to 4 doses

1. The most common adverse reactions are reactions of the central nervous system, manifested as blurred vision, diplopia, and nystagmus. 2. Water retention and hyponatremia (or water intoxication) caused by stimulation of antidiuretic hormone secretion, with an incidence of about 10% to 15%. 3. Less common adverse reactions include allergic reactions, Stevens-Johnson syndrome or toxic epidermal necrolysis, rash, urticaria, itching; behavioral disorders in children, severe diarrhea, and lupus erythematosus-like syndrome (urticaria, itching, rash, fever, sore throat, bone or joint pain, fatigue). 4. Rare adverse reactions include glandular disease, arrhythmia or atrioventricular block (especially for the elderly), bone marrow suppression, central nervous system poisoning (language difficulties, mental restlessness, tinnitus, tremor, hallucinations), allergic hepatitis, hypocalcemia, direct impact on bone metabolism leading to osteoporosis, kidney poisoning, peripheral neuritis, acute urinary porphyria, thromboangiitis, allergic pneumonia, acute intermittent porphyria, and hypothyroidism. There was a case of myoclonic epilepsy with aseptic meningitis, which caused recurrence of meningitis after receiving this product. Occasionally, granulocytopenia, reversible thrombocytopenia, aplastic anemia, and toxic hepatitis are seen.

Contraindications: Patients with a history of atrioventricular block, severe serum iron abnormalities, bone marrow suppression, severe liver dysfunction, etc.

1. When used in combination with acetaminophen, especially in a single overdose or long-term large doses, the risk of liver poisoning increases, which may reduce the efficacy of the latter. 2. When used in combination with coumarin anticoagulants, due to the positive induction of liver enzymes by this product, the blood concentration of anticoagulants is reduced, the half-life is shortened, and the anticoagulant effect is weakened. The prothrombin time should be measured and the dosage should be adjusted. 3. When used in combination with carbonic anhydrase inhibitors, the risk of osteoporosis increases. 4. Due to the liver enzyme induction effect of this product, when used in combination with chlorpropamide, clofibrate (clofibrate), desmopressin, lypressin, vasopressin, vasopressin, etc., the antidiuretic effect can be enhanced, and the dosage of each combined drug needs to be reduced. 5 When used in combination with estrogen-containing contraceptives, cyclosporine, digitalis (except possibly digoxin), estrogen, levothyroxine or quinidine, the effects of these drugs will be reduced due to the positive induction of liver metabolic enzymes by carbamazepine, and the dosage should be adjusted to use oral contraceptives containing only progestin (progesterone). Vaginal bleeding may occur when used in combination with oral contraceptives. 6 When used in combination with doxycycline (doxycycline), the latter's blood concentration may be reduced, and the dosage needs to be adjusted if necessary. 7 Erythromycin, troleandomycin and detropropoxyphene can inhibit the metabolism of carbamazepine, causing the latter's blood concentration to increase and toxic reactions to occur. 8 Haloperidol, loxapine, maprotiline, thioxanthenes or tricyclic antidepressants can enhance the metabolism of carbamazepine, causing the latter's blood concentration to increase and toxic reactions to occur. 9 Lithium salts can reduce the antidiuretic effect of carbamazepine. 10 When used in combination with monoamine oxidase (MAO) inhibitors, it can cause high fever or (and) hypertensive crisis, severe convulsions, and even death. The two drugs should be used at least 14 days apart. When carbamazepine is used as an anticonvulsant, MAO inhibitors can change the type of epileptic seizure. 11 Carbamazepine can reduce the absorption of nomifensine and accelerate its elimination. 12 Phenobarbital and phenytoin accelerate the metabolism of carbamazepine and can reduce the t1/2 of carbamazepine to 9-10 hours.

0.2g

THE Central Pharmaceutical Co., Ltd.

• Founded in:

  1996-12-19

• Address:

  Room 416, No. 10, Yizhong Road, Beichen Science and Technology Industrial Park, Tianjin New Technology Industrial Park (multiple address information exists)

• Tax NO.:

  911201131030707061

• Registered Funds:

  82.35 million yuan

• Website:

  Log in to view

• Email:

  Log in to view