Clindamycin Hydrochloride Capsules
Ingredients
The main ingredient of this product is clindamycin hydrochloride.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Clindamycin hydrochlorideIngredients |
Extract from the above information More |
21462-39-5 | 34 |
Appearance
This product is in the form of capsules.
Usage and Dosage
For adults, take 0.15-0.3g orally 4 times a day. For severe infection, the dosage can be increased to 0.45g orally 4 times a day. For children aged 4 weeks or older, take 8-16mg/kg per day, divided into 3-4 times.
Adverse Reactions
1. Gastrointestinal reactions: including nausea, vomiting, abdominal pain, diarrhea, etc.; severe cases include abdominal cramps, abdominal tenderness, severe diarrhea (watery or purulent), accompanied by fever, abnormal thirst and fatigue (pseudomembranous enterocolitis). Diarrhea, enteritis and pseudomembranous enterocolitis may occur during treatment or after drug withdrawal. 2. Allergic reactions: usually mild to moderate measles-like rash is the most common, followed by vesicular rash and urticaria, occasionally erythema multiforme, exfoliative dermatitis, and some manifestations of Stevens-Johnson syndrome. 3. Abnormal liver function and renal function may occur, and occasionally neutropenia and eosinophilia may occur.
Precautions
It is contraindicated in patients with a history of hypersensitivity to clindamycin and lincomycin.
Special Population Medication
Precautions for children: It is not suitable for children under 1 month old. Precautions for pregnancy and lactation: Animal experiments show that this product has no effect on the fetus, but there is still a lack of experience in its use in pregnant humans, so it should still be used with caution in pregnant women. This product can be secreted into breast milk, and lactating women must suspend breastfeeding if they really need to use the drug. Precautions for the elderly: There is not enough data on the elderly in the clinical studies of this product, so it is not certain whether the elderly react to this drug differently from young people. For young and elderly volunteers with normal liver and kidney function, oral or intravenous administration of clindamycin did not show clinically significant differences in pharmacokinetics. It has been reported that diarrhea and antibiotic-associated colitis are more common and more severe in the elderly. Therefore, elderly patients with diarrhea should be closely monitored.
Drug Interactions
1. It can enhance the neuromuscular blockade of inhaled anesthetics, leading to skeletal muscle weakness and respiratory depression or paralysis (apnea). Caution should be exercised when used together during or after surgery. Treatment with anticholinesterase drugs or calcium salts is expected to be effective. 2. Used together with antiperistaltic antidiarrheal drugs and antidiarrheal drugs containing kaolin: Clindamycin may cause pseudomembranous colitis with severe watery diarrhea during the course of treatment or even several weeks after the course of treatment. Antiperistaltic antidiarrheal drugs should not be used together because they can delay the excretion of toxins in the colon, leading to prolonged and aggravated diarrhea. If antidiarrheal drugs containing kaolin and clindamycin are taken orally at the same time, the absorption of the latter will be significantly reduced. Therefore, the two should not be taken at the same time and a certain time interval (at least 2 hours) must be allowed. 3. This product has a neuromuscular blocking effect. When used together with anti-myasthenic drugs, the latter's effect on skeletal muscle will be reduced.
Storage
Keep sealed.
Packaging Specification
75mg*10s
Validity Period
24 months