Gentamycin Sulfate Granules

This product is an aminoglycoside antibiotic. It has good antibacterial effects on various Gram-negative and Gram-positive bacteria, and has good effects on various Enterobacteriaceae such as Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, Enterobacter, Serratia and Pseudomonas aeruginosa. Neisseria and Haemophilus influenzae are moderately sensitive to this product. It also has a certain effect on Brucella, Yersinia pestis, Acinetobacter and Campylobacter fetus. It has a good antibacterial effect on about 80% of methicillin-sensitive strains of Staphylococcus (including Staphylococcus aureus and coagulase-negative Staphylococci), but most methicillin-resistant strains are resistant to this product. It has a poor effect on Streptococcus and Streptococcus pneumoniae, and Enterococcus is mostly resistant to this product. When this product is used in combination with β-lactams, most of them can obtain a synergistic antibacterial effect. The mechanism of action of this product is to bind to the 30S subunit of the bacterial ribosome and inhibit the synthesis of bacterial proteins. In recent years, the number of Gram-negative bacteria resistant to gentamicin has increased significantly.

The main ingredient of this product is gentamicin sulfate

This product is a granule with added flavoring agent.

It is used for intestinal infectious diseases such as dysentery and enteritis caused by sensitive bacteria, and can also be used for cleaning the intestinal cavity before surgery.

Oral administration: Adults: 80-160 mg once, 3-4 times a day; children: 10-15 mg/kg per day, divided into 3-4 times.

1. Nausea, loss of appetite, vomiting, abdominal distension and other gastrointestinal symptoms and rash, serum aminotransferase elevation, etc. are rare. 2. Hearing loss, tinnitus or fullness in the ears (ototoxicity), hematuria, significantly reduced urination frequency or urine volume, loss of appetite, extreme thirst (nephrotoxicity), unsteady gait, dizziness (ototoxicity, vestibular effects), dyspnea, drowsiness, extreme weakness (neuro-muscle blockade) are rare.

It is contraindicated in patients who are allergic to aminoglycoside antibiotics.

Precautions for children: Due to potential ototoxicity and nephrotoxicity, this product should be used with caution in children. Precautions for pregnancy and lactation: Although this product is poorly absorbed after oral administration, it should still be used with caution in pregnant women because the absorbed part can enter the fetal circulation through the placenta. Lactating women should suspend breastfeeding during medication. Precautions for the elderly: Due to potential ototoxicity and nephrotoxicity, this product should be used with caution in elderly patients.

1. When used in combination with other aminoglycosides or used sequentially, it may increase the possibility of ototoxicity, nephrotoxicity and neuromuscular blocking effects. When used in combination with neuromuscular blockers, it may aggravate neuromuscular blocking effects. 2. When used in combination with capreomycin, cisplatin, ethacrynic acid, furosemide or vancomycin or used sequentially, it may increase the possibility of ototoxicity and nephrotoxicity. 3. When used in combination with cephalothin, it may increase nephrotoxicity. 4. When used in combination with polymyxins or used sequentially, it may increase nephrotoxicity and neuromuscular blocking effects. 5. Other nephrotoxic and ototoxic drugs should not be used in combination with this product or used sequentially to avoid aggravating nephrotoxicity or ototoxicity.

Seal tightly and store in a cool, dark place.

10mg (10,000 units)

18 months

Hebei Huachen Pharmaceutical Group Co., Ltd.

• Founded in:

  2005-07-22

• Address:

  Huanghua Economic and Technological Development Zone, 307 National Road North Old City Industrial Park

• Tax NO.:

  91130983777722037E

• Registered Funds:

  60 million yuan

• Website:

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