Cefathiamidine for injection

1. Pharmacology: This product has antibacterial activity against Gram-positive bacteria and some Gram-negative bacteria, and is particularly effective against Gram-positive cocci. The in vitro antibacterial activity test of this product shows that it has strong antibacterial activity against pneumococci, Streptococcus pyogenes, Staphylococcus aureus (MSSA strain), Staphylococcus epidermidis (MSSE strain) and Branhamella catarrhalis. The MIC90 for Streptococcus pneumoniae is 0.25μg/ml, the MIC90 for Streptococcus pyogenes is 0.5μg/ml, and the MIC90 for the other three bacteria is less than 8.0μg/ml. It also has strong antibacterial activity against Haemophilus influenzae, with a MIC90 of 2.0μg/ml. It has good antibacterial effects on viridans streptococci, hemolytic streptococci, non-hemolytic streptococci, diphtheria bacillus, perfringens, tetani bacillus and anthrax bacillus. The in vitro antibacterial activity against Staphylococcus aureus (MRSA strain) and Staphylococcus epidermidis (MRSE strain) is inferior to that of vancomycin. The mechanism of action of this product is to inhibit the cell wall synthesis of sensitive bacteria, thereby producing a bactericidal effect. 2. Toxicology: The LD50 of this product for intravenous injection in mice is (1.02±0.04) g/kg, and the LD50 of intraperitoneal injection is (1.26±0.23) g/kg. In the reproductive toxicity test, the fetal mortality rate of mice in the test group was significantly higher than that in the control group (P<0.01).

The main ingredient of this product is cefathiamidine, and its chemical name is (6R,7R)-3-[(acetyloxy)methyl]-7-[α-(N,N-diisopropylamidinothio)acetylamino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid betaine.

This product is white or off-white crystalline powder; almost odorless and hygroscopic.

Used for respiratory system, hepatobiliary system, ENT, urinary tract infections, endometritis and sepsis caused by sensitive bacteria.

Intramuscular injection: 0.5g~1.0g once, 4 times a day; children can take 50~100mg/kg per day according to their body weight, divided into 3~4 doses. Intravenous injection: 2g once, 2~4 times a day; children can take 50~100mg/kg per day according to their body weight, divided into 2~4 doses. Dissolve the mixture in sterile water for injection or sodium chloride injection solution before use.

Occasionally, there are urticaria, asthma, itchy skin, chills and high fever, angioedema, etc. Occasionally, non-protein nitrogen and alanine aminotransferase increase after treatment

It is contraindicated for those who are allergic to cephalosporin antibiotics. [Use in pregnant and lactating women] It should be used with caution in early pregnancy. Although there have been no reports of problems with the use of cephalosporins in lactating women, the pros and cons of its use must still be weighed. [Use in the elderly] Elderly patients have impaired renal function, so the dosage should be appropriately reduced when using it.

Precautions during pregnancy and lactation: Use with caution in women in early pregnancy or lactation.

After intramuscular injection of this product combined with probenecid 1g, the 12-hour urine excretion volume dropped to 65.7% of the administered dose.

Keep away from light, tightly closed, in a cool and dry place.

0.5 g

Guangdong Jincheng Jinsu Pharmaceutical Co., Ltd.

• Founded in:

  2015-05-25

• Address:

  No. 10, Shennong Road, Torch Development Zone, Zhongshan City, Guangdong Province

• Tax NO.:

  91442000337901760P

• Registered Funds:

  60.606 million yuan

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