Cefaclor Capsules

This product is a broad-spectrum semi-synthetic cephalosporin antibiotic. Its activity against penicillinase-producing Staphylococcus aureus, group A hemolytic streptococci, viridans streptococci and Staphylococcus epidermidis is the same as that of cefadroxil, and its antibacterial effect against non-enzyme-producing Staphylococcus aureus and pneumococci is 2 to 4 times stronger than that of cefadroxil. Its activity against Gram-negative bacilli, including Escherichia coli and Klebsiella pneumoniae, is stronger than that of cefadroxil, and is similar to that of cefadroxil. Its activity against Proteus mirabilis, Salmonella and Shigella is stronger than that of cefadroxil. 2.9 to 8 mg/L of this product can inhibit all Haemophilus influenzae, including strains resistant to ampicillin. Moraxella catarrhalis and Neisseria gonorrhoeae are very sensitive to this product. Indole-positive Proteus, Serratia, Acinetobacter and Pseudomonas aeruginosa are all resistant to this product. The mechanism of action of this product is to inhibit the synthesis of bacterial cell walls.

The main ingredient of this product is cefaclor. Its chemical name is (6R,7R)-7-[(R)-2-amino-2-phenylacetylamino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate. [Molecular formula] C15H14ClN3O4S·H2O [Molecular weight] 385.82

Capsules, the contents are white to light yellow powder.

It is mainly used for respiratory system, urinary system, ENT, skin and soft tissue infections caused by sensitive bacteria.

Oral: The usual adult dose is 0.25g once, 3 times a day. The dose can be doubled for patients with severe infection, but the total daily amount should not exceed 4.0g. Or follow the doctor's advice.

1. Common gastrointestinal reactions: soft stools, diarrhea, stomach discomfort, loss of appetite, nausea, vomiting, belching, etc. 2. Serum sickness-like reactions are more common than other antibiotics, especially in children. Typical symptoms include skin reactions and joint pain. 3. Allergic reactions: rash, urticaria, eosinophilia, vulvar itching, etc. 4. Others: mild increase in serum aminotransferase, urea nitrogen and creatinine, proteinuria, cystic urine, etc.

It is contraindicated in patients allergic to cephalosporins.

Precautions for children: The efficacy and safety of this product for infants under one month have not yet been established. Precautions for pregnancy and lactation: Use with caution in pregnant and lactating women. Precautions for the elderly: According to literature reports, compared with healthy adult subjects under 45 years old, 40-50% of healthy elderly subjects (over 65 years old) who took 750 mg of cefaclor alone had high AUC and 20% had low renal clearance. These differences are mainly caused by age-related functional renal diseases. In clinical studies, when elderly patients took the recommended adult dose, the clinical effect and safety were similar to those of adult patients, and the doses taken by elderly patients were no different. Therefore, unless the elderly patients are weak, malnourished, and have severe renal impairment, there is generally no need to adjust the dose.

1. Furosemide, ethacrynic acid, bumetanide and other strong diuretics, carmustine, streptozocin and other antineoplastic drugs and aminoglycoside antibiotics and other nephrotoxic drugs combined with this product may increase nephrotoxicity. 2. Clavulanic acid can enhance the antibacterial activity of this product against certain Gram-negative bacteria that are resistant to this product due to the production of b-lactamase. 3. Oral administration of probenecid can delay the excretion of this product.

Keep away from light, seal tightly, and store in a cool, dark and dry place.

0.25 g (calculated as C15H14ClN304S)

24 months

Suzhou No.3 Pharmaceutical Factory Co., Ltd.

• Founded in:

  1981-12-14

• Address:

  No. 8, Jinzi Road, Fenhu High-tech Industrial Development Zone, Wujiang District, Suzhou

• Tax NO.:

  91320509137703209P

• Registered Funds:

  4.2 million yuan

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