Halcinonide Cream
Function and Efficacy
1. Anti-inflammatory effect This product is a topical drug, a highly effective fluorinated and chlorinated corticosteroid with anti-inflammatory, anti-itching and vasoconstriction effects. This product replaces the 21-hydroxyl group with a chlorine atom on the skeleton of triamcinolone. The anti-inflammatory potency multiple determined by the vasoconstriction test is 360. There is evidence that the intensity of the vasoconstriction test is consistent with the efficacy. Its anti-inflammatory and antipruritic mechanism is to increase the reactivity of beta receptors to catecholamine, increase the production of CAMP by activating adenylate cyclase, and reduce the destruction of CAMP by inhibiting phosphoethylesterase, resulting in an increase in the annual concentration of cAMP in cells and inhibiting the release of histamine. The effect of this product in inhibiting the proliferation of granulomas in rats and mice is similar to that of dexamethasone. Using the formaldehyde-induced heel swelling method for mice and rats, this product and dexamethasone both have significant inhibitory effects, while hydrocortisone with a 5-fold higher dose has no inhibitory effect. This product has a significant weight loss effect on the thymus and spleen. 2. Selective pharmacological effects on various types of cells: reduce the number of T lymphocytes, monocytes, and eosinophils, inhibit lymphocyte proliferation and cytokine production, inhibit macrophage differentiation and phagocytic activity, inhibit neutrophil adhesion, reduce vascular endothelial cell permeability, inhibit fibroblast proliferation and collagen synthesis, and inhibit sebaceous gland cell activity. 3. Anti-proliferative effect This product has an anti-mitotic effect. It reduces the transcription of PNA, thereby reducing DNA synthesis and also affects DNA repair, resulting in thinning of the epidermis, especially the greatest impact on collagen synthesis. 4. Immunosuppressive effect This product binds to the corticosteroid receptors in the cytoplasm, causing a series of reactions and activating the expression of lytic genes in the cells; it induces nuclear DNA lysis in lymphocytes and directly kills lymphocytes.
Ingredients
Halcinonide (clofosinolone, halcinonide). Chemical name: 16,17-[(1-methylethylidene)bis(oxy)-11-hydroxy-21-chloro-9-fluoropregnane-4-ene-3,20-dione.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| HalcinonideIngredients |
1. Anti-inflammatory effect: highly effective fluorinated and chlorinated corticosteroids with anti-inflammatory, anti-itching and vasoconstrictive effects; 2. Selective pharmacological effects on various types of cells: reducing the number of T lymphocytes, monocytes, and eosinophils, inhibiting lymphocyte proliferation and cytokine production, inhibiting macrophage differentiation and phagocytic activity, inhibiting neutrophil adhesion, reducing vascular endothelial cell permeability, inhibiting fibroblast proliferation and collagen synthesis, and inhibiting sebaceous gland cell activity; 3. Anti-proliferative effect: has anti-mitotic effect, reduces DNA synthesis and repair, and thins the epidermis, especially the greatest effect on collagen synthesis; 4. Immunosuppressive effect: by binding to the corticosteroid receptors in the cytoplasm, activating the expression of lytic genes, inducing nuclear DNA lysis in lymphocytes, and directly killing lymphocytes and causing their death. More |
3093-35-4 | 9 |
Appearance
White cream with emulsion base
Indication
Contact eczema, atopic dermatitis, neurodermatitis, small-scale psoriasis, lichen sclerosus atrophicus, lichen planus, discoid lupus erythematosus, seborrheic dermatitis (non-facial) hypertrophic scars.
Usage and Dosage
Apply to the affected area once in the morning and evening.
Adverse Reactions
A small number of patients experience burning sensation, stinging, and temporary itching at the site of application. Long-term use may cause dilation of skin capillaries (especially on the face), skin atrophy, and stretch marks (prone to adolescents). Skin atrophy may be followed by purpura, ecchymosis, skin fragility, hirsutism, folliculitis, miliary papules, skin depigmentation, and delayed ulcer healing. The packing method is prone to secondary fungal infection in skin folds. When absorbed through the skin for a long time, systemic adverse reactions may occur (see precautions).
Precautions
1. Contraindicated for those who are allergic to the drug; 2. Contraindicated for primary skin lesions caused by bacteria, fungi, viruses and parasites; 3. Contraindicated for ulcerative lesions; 4. Contraindicated for acne and alcoholic rhinitis; 5. Contraindicated for eyelids (risk of causing glaucoma); 6. Contraindicated for exudative skin diseases
Special Population Medication
Precautions for children: It should be applied to the area and for a short period of time. Once the symptoms subside, stop the drug immediately. Children under one year old should try not to use this drug. Precautions for pregnancy and lactation: There is no research on the teratogenic effect of topical medication. It should be used with caution during pregnancy. When a large amount of topical medication is absorbed through the skin, it can be excreted from breast milk. Use with caution during lactation. Precautions for the elderly: Follow the doctor's advice.
Drug Interactions
Not yet clear
Storage
Store tightly closed at room temperature.
Packaging Specification
10 g: 10 mg
Validity Period
24 months
Manufacturer
Guangdong Cr.shunfeng Pharmaceutical Co., Ltd.
-
Founded in:
1997-01-23 -
Address:
Jinjuzui, Daliang Street, Shunde District, Foshan City -
Tax NO.:
91440606617652957Q -
Registered Funds:
50 million yuan -
Website:
-
Email: