Minocycline Hydrochloride Capsules

Pharmacology: This product is a semi-synthetic tetracycline-type broad-spectrum antibiotic with high efficiency and long-lasting effect. Among tetracycline antibiotics, this product has the strongest antibacterial effect. The antibacterial spectrum is similar to that of tetracycline. It has a strong effect on Gram-positive bacteria, including tetracycline-resistant Staphylococcus aureus, Streptococcus, and Gram-negative bacteria, including Neisseria gonorrhoeae; the effect on Gram-negative bacilli is generally weaker; this product also has a good inhibitory effect on Chlamydia trachomatis and Ureaplasma urealyticum. In recent years, due to the abuse of tetracycline antibiotics, most common Gram-positive and Gram-negative bacteria are now resistant to this product. The mechanism of action of this product is to bind to the A position of the 30S subunit of the ribosome, prevent the extension of the peptide chain, and thus inhibit the protein synthesis of bacteria or other pathogenic microorganisms. This product is an antibacterial drug, but at high concentrations, it also has a bactericidal effect. Toxicology: This product can cause the thyroid gland of experimental animals (rats, dogs and monkeys) to turn black. Rats given this product for chronic treatment resulted in goiter and even thyroid tumors. This product can also cause thyroid hyperplasia in rats and dogs.

The main ingredients of this product are: minocycline hydrochloride. Molecular weight: C23H27N3O7·HCl

This product is in the form of capsules.

This product is suitable for the following infections caused by pathogens sensitive to this product, such as Staphylococcus, Streptococcus, Pneumococcus, Neisseria gonorrhoeae, Shigella dysenteriae, Escherichia coli, Klebsiella, Proteus, Pseudomonas aeruginosa, Treponema pallidum and Chlamydia.

Oral administration. The first dose for adults is 0.2 g, and then 0.1 g after 12 or 24 hours, or as directed by a doctor. For acne vulgaris, take 50 mg each time, twice a day, for a course of 6 weeks.

1. Dysbacteriosis: This product is more likely to cause dysbacteriosis. In mild cases, it causes vitamin deficiency, and secondary infection caused by Candida albicans and other drug-resistant bacteria is also common. Clostridium difficile pseudomembranous enteritis may also occur. 2. Digestive tract reactions: loss of appetite, nausea, vomiting, abdominal pain, diarrhea, stomatitis, glossitis, perianal inflammation, etc.; esophageal ulcers may occur occasionally. 3. Liver damage: nausea, vomiting, jaundice, fatty liver, elevated serum aminotransferase, hematemesis and bloody stools may occur occasionally, and severe cases may lead to coma and death. 4. Renal damage: It can aggravate renal damage in patients with renal insufficiency, leading to elevated blood urea nitrogen and creatinine values. 5. Affecting tooth and bone development: This product can be deposited in teeth and bones, causing yellowing of teeth, and affecting the normal development of bones in fetuses, newborns and infants. 6. Allergic reactions: It is mainly manifested as rash, urticaria, drug fever, photosensitivity dermatitis and asthma. Systemic lupus erythematosus is rare. If it occurs, the drug should be discontinued immediately and appropriate treatment should be given. 7. Vestibular dysfunction such as dizziness, tinnitus, ataxia accompanied by nausea and vomiting may be seen (dose-dependent, more common in women than in men). It often occurs at the first few doses and can generally be recovered after 24 to 48 hours of discontinuation of the drug. 8. Blood system: Occasionally there may be hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia, etc. 9. Vitamin deficiency: Occasionally there may be symptoms of vitamin K deficiency (hypoprothrombinemia, bleeding tendency, etc.), vitamin B deficiency symptoms (glossitis, stomatitis, loss of appetite, neuritis, etc.). 10. Increased intracranial pressure: Occasionally there may be symptoms of increased intracranial pressure such as vomiting, headache, diplopia, papilledema, and bulging anterior fontanelles. The drug should be discontinued immediately. 11. Shock: Shock may occur occasionally. Please pay attention to observation. If you find any discomfort, abnormal sensation in the mouth, asthma, urge to defecate, tinnitus and other symptoms, you should stop taking the drug immediately and take appropriate measures. 12. Skin: maculopapular rash, erythematous rash, etc.; occasionally exfoliative dermatitis, mixed drug eruption, erythema multiforme and Steven-Johnson syndrome. Long-term use of this product may occasionally cause pigmentation on the nails, skin and mucous membranes. 13. Others: Occasionally dizziness, fatigue, etc. Long-term use of this product may cause the thyroid gland to turn brown-black, and abnormal thyroid function is rare. Hearing loss is rare.

Patients who are allergic to this product or other tetracyclines are contraindicated.

Precautions for children: Since this product can cause permanent discoloration of teeth, enamel hypoplasia, and inhibit the development and growth of bones, it is contraindicated for children under 8 years old. Precautions for pregnancy and lactation: 1. This product can enter the fetus through the blood-placenta barrier and deposit in the calcium area of teeth and bones, causing fetal enamel hypoplasia and inhibiting fetal bone growth; it has teratogenic effects in animal experiments. Therefore, it is contraindicated for pregnant women and women who are preparing to become pregnant. 2. This product has a high concentration in breast milk. Although it can form an insoluble complex with calcium in breast milk and absorb very little, since this product can cause permanent discoloration of teeth, enamel hypoplasia, and inhibit the development and growth of infant bones, breastfeeding should be suspended during the medication period for lactating women. Precautions for the elderly: The clinical trials of this product did not include enough patients over 65 years old, so it is impossible to determine whether the reactions of the elderly after taking the drug are the same as those of young people. The dose selection for elderly patients should be cautious, usually starting with the minimum dose, because the elderly are more likely to have reduced liver, kidney or heart function, and may also suffer from other diseases or be taking other drugs.

1. Since this product can reduce the hysteresis of prothrombin, the dosage of anticoagulants should be reduced when this product is used in combination with anticoagulants. 2. Since antacids (sodium bicarbonate) can reduce the absorption and activity of this product, this product and antacids should be avoided from being taken at the same time. 3. When this product is used in combination with drugs containing aluminum, calcium, magnesium, and iron ions, an insoluble complex may be formed, which reduces the absorption of this product. 4. When lipid-lowering drugs choloslyramine or colestipol are used in combination with this product, the absorption of this product may be affected. 5. Since barbiturates, phenytoin, or carbamazepine can induce the activity of microsomal enzymes, resulting in a decrease in the blood concentration of this product, the dosage of this product needs to be adjusted when used in combination. 6. The combination of the general anesthetic methoxyflurane and this product can cause pathogenic

Keep tightly closed in a cool, dry place.

50mg

36 months

North China Pharmaceutical Company.Ltd

• Founded in:

  1992-12-20

• Address:

  No. 388, Heping East Road, Shijiazhuang City

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  91130100104397700P

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