Lysine aspirin powder

This product is a complex salt of aspirin and lysine. It is a nonsteroidal anti-inflammatory drug, which dissociates into aspirin in the body and has antipyretic, analgesic and anti-inflammatory effects. ① Analgesic effect: It is mainly through inhibiting the synthesis of prostaglandins and other substances that can make pain sensitive to mechanical or chemical stimulation (such as bradykinin, histamine), and is a peripheral analgesic. However, the possibility of central analgesia (possibly acting on the hypothalamus) cannot be ruled out; ② Anti-inflammatory and anti-rheumatic effects; The exact mechanism is still unclear, it may be due to the fact that this product acts on inflamed tissues and inhibits the synthesis of prostaglandins or other substances that can cause inflammatory reactions (such as histamine) to play an anti-inflammatory role. Inhibition of the release of lysosomal enzymes and leukocyte chemotaxis may also be related to it; ③ Antipyretic effect: It may act on the hypothalamic temperature regulation center to cause peripheral vasodilation, increased skin blood flow, sweating, and increased heat dissipation to play an antipyretic role. This central effect may be related to the inhibition of prostaglandin synthesis in the hypothalamus; ④ The effect of inhibiting platelet aggregation: it works by inhibiting platelet cyclooxygenase and reducing the production of prostaglandins.

Lysine aspirin

This product is white powder, odorless, slightly sour, and unstable to moisture and heat.

Used to relieve mild or moderate pain and fever caused by various reasons, and for relieving symptoms of rheumatoid arthritis, osteoarthritis, etc.

Oral administration. This product should be dissolved in cold boiled water (20℃ or lower) and taken immediately. The higher the water temperature or the longer it is left after washing, the easier it is for this product to decompose into salicylic acid. Antipyretic and analgesic: 0.45g~0.9g (1-2 packs) at a time, 2-3 times a day. Anti-rheumatic: 0.9g~1.8g (2-4 packs) at a time, 4 times a day, or as directed by a doctor.

The doses generally used for antipyretic and analgesic rarely cause adverse reactions. Long-term and large-scale use of the drug (for the treatment of rheumatic fever), especially when the blood concentration of the drug is 200mg/m1, is more likely to cause adverse reactions. The higher the blood concentration, the more obvious the adverse reactions. 1. The more common gastrointestinal reactions are nausea, vomiting, upper abdominal discomfort or pain, which can disappear after stopping the drug. Long-term or large-dose use may cause gastrointestinal bleeding or ulcers. 2. Central nervous system: reversible tinnitus and hearing loss occur, which often occur after a certain course of treatment and the blood concentration of the drug reaches 200-300mg/m1. 3. Allergic reaction: manifested as asthma, urticaria, angioedema or shock. Most of them are susceptible people, and they quickly develop breathing difficulties after taking the drug. Severe cases can cause death, which is called aspirin asthma. Some are aspirin allergy, asthma and nasal polyps triple syndrome, which is often related to genetic and environmental factors. 4. Damage to liver and kidney function is related to the dosage, especially when the dosage is too high and the blood drug concentration reaches 250mg/ml. The damage is reversible and can be restored after stopping the drug, but there are reports of renal papillary necrosis.

It should not be used in the following situations: ① Active ulcer disease or gastrointestinal bleeding caused by other reasons; ② Hemophilia or thrombocytopenia; ③ Those with a history of allergy to aspirin or other non-steroidal anti-inflammatory drugs, especially those with asthma, angioedema or shock.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: Not yet clear.

(1) When used with other nonsteroidal anti-inflammatory drugs, gastrointestinal adverse reactions increase, but the efficacy is not enhanced. (2) Antacids (long-term and large-scale use) or urine alkalinizing drugs: Alkaline urine can increase the excretion of this product and reduce the blood concentration. When the blood concentration has reached a stable state, stopping the use of alkaline drugs can increase the blood concentration to toxic levels. Caution should be exercised. (3) When used with oral anticoagulants, the risk of bleeding may increase. (4) Carbonic anhydrase inhibitors can alkalinize urine and even cause metabolic acidosis, which can not only increase the excretion of salicylate and reduce blood concentration, but also increase the amount that penetrates into brain tissue, resulting in toxic reactions. (5) Glucocorticoids can increase the excretion of salicylate. When used together, in order to maintain the blood concentration of this product, the dosage of this product should be increased if necessary. In addition, there is a risk of gastrointestinal ulcers. (6) The efficacy of insulin or oral hypoglycemic drugs can be enhanced by using this product together. (7) When used with methotrexate (MTX), it can reduce the binding of methotrexate to proteins and reduce its excretion from the kidneys, causing blood concentrations to increase and toxic reactions to increase. (8) The uricosuric effect of probenecid or sulfinpyrazone can be reduced by the simultaneous use of this product; the reduction is obvious when the blood concentration of salicylate is 50μg/ml, and even more so when it exceeds 100-150μg/ml. In addition, probenecid can reduce the clearance rate of salicylate from the kidneys, thereby increasing the latter's blood concentration. (9) Uric acid drugs: Acidic urine can reduce the excretion of salicylate, causing the latter's blood concentration to increase. Patients whose blood concentration of salicylate has reached a stable state may experience an increase in blood concentration of salicylate and increased toxic reactions after the addition of uricosuric drugs.

Keep away from light and store in a sealed container.

2g:0.45g

18 months

Jilin Aodong--Taonan Pharnalentical Company Ltd

• Founded in:

  1998-02-06

• Address:

  No. 2999, Xingye Road, Taonan Economic Development Zone, Jilin Province

• Tax NO.:

  912208007022438244

• Registered Funds:

  70.170757 million yuan

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