Norfloxacin Tablets

This product is a fluoroquinolone antibacterial drug with a broad-spectrum antibacterial effect, especially high antibacterial activity against aerobic Gram-negative bacteria. It has good antibacterial activity against the following bacteria in vitro: most bacteria of the Enterobacteriaceae family, including Citrobacter, Enterobacter cloacae, Enterobacter aerogenes and other Enterobacteriaceae, Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, Vibrio, Yersinia, etc. Norfloxacin also has antibacterial activity against multi-drug resistant bacteria in vitro. It also has good antibacterial effect against penicillin-resistant Neisseria gonorrhoeae, Haemophilus influenzae and Moraxella catarrhalis. Norfloxacin is a bactericide that acts on the A subunit of bacterial DNA helicase, inhibits DNA synthesis and replication, and causes bacterial death. Pharmacology and toxicology: A broad-spectrum antibacterial drug that has effects on both Gram-positive and Gram-negative bacteria. Bacteria are not easy to develop resistance to this product, and there is no cross-resistance between similar drugs and antibiotics. It has strong antibacterial activity against Gram-negative bacilli, especially bacteria of the Enterobacteriaceae family, such as Escherichia coli, Shigella, Klebsiella, Proteus, Enterobacter aerogenes, Serratia, Citrobacter, etc., which are highly sensitive to this product, and the minimum inhibitory concentration is generally less than 0.5mu;g/ml. Influenzae is also highly sensitive to this product. It also has an effect on Pseudomonas aeruginosa and other Pseudomonas, but requires a higher concentration, with a minimum inhibitory concentration of 4 to 32mu;g/ml; because the concentration of this product in urine exceeds the above concentration by several to more than ten times, it is still effective for the treatment of Pseudomonas aeruginosa urinary tract infections. Among Gram-positive cocci, it is more sensitive to Staphylococcus aureus and Staphylococcus epidermidis, and the minimum concentration for inhibiting 90% of bacteria is about 1 to 2mu;g/ml, and the minimum concentration for inhibiting 90% of enterococci and pneumococci is about 4mu;g/ml and 16mu;g/ml.

Norfloxacin

This product is a sugar-coated tablet. After removing the sugar coating, it is light yellow. It is relatively stable to light, heat and humidity.

It is suitable for acute and chronic pyelonephritis, cystitis, prostatitis, bacterial dysentery, cholecystitis, typhoid fever, pre- and postpartum infection, pelvic inflammatory disease, otitis media, sinusitis, acute tonsillitis and skin and soft tissue infection caused by sensitive bacteria. It can also be used as a preventive medicine for abdominal surgery.

Take orally on an empty stomach. Adults take 0.1-0.2g at a time, 3-4 times a day. For severe cases, increase the dosage as appropriate, 1.6g a day, divided into 4 times.

Occasionally, symptoms such as dizziness, headache, and gastrointestinal reactions may occur. Some patients may have elevated serum alanine aminotransferase and urea nitrogen, and occasionally allergic rashes. The symptoms disappear after stopping the drug.

Patients who are allergic to this product and fluoroquinolones are contraindicated.

Precautions for children: Patients under 18 years of age are prohibited from using this drug. Precautions for pregnancy and lactation: Reproduction studies have been conducted on monkeys with doses as high as 10 times the human dose, and it was found that this product can cause abortion. The peak plasma concentration (Cmax) of this dose in monkeys is about twice that of humans. This product has not been proven to be teratogenic in animals. However, no appropriate and well-controlled studies have been conducted in pregnant women, so this product should not be used in pregnant women. There is still a lack of information on whether this product is secreted through breast milk. When a lactating woman uses 200 mg of this product, the drug cannot be detected in breast milk. However, due to the small study dose, and the fact that other varieties of this class of drugs are secreted through breast milk, coupled with the potential serious adverse reactions to newborns and infants, lactating women should avoid using this product or stop breastfeeding when using it. Precautions for the elderly: Elderly patients often have impaired renal function, and because this product is partially excreted through the kidneys, it needs to be used in a reduced dose.

Not yet clear.

Keep away from light and store in sealed container.

0.1g

24 months