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Norfloxacin

Norfloxacin structure

CAS No:
70458-96-7
Formula:
C16H18FN3O3
Chemical Name:
Norfloxacin
Synonyms:
3-Quinolinecarboxylic acid,1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-;1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid;AM 715;Mk 0366;Norfloxacin;4803P;N-Demethylpefloxacin;Baccidal;N-Desmethylpefloxacin;Norphloxacine;Chibroxin;Noroxin;Norfloxacine;Floxacin 400;Noflo;Spectrama;Noroxine;Barazan;Floxacin;Utinor;Fulgram;Gonorcin;Sebercim;Chibroxine;Noraxin;Norxacin;Chibroxol;Lexinor;Zoroxin;Uroxacin;Norocin;Noracin;Nolicin;1-Ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid;Norflox 400;Norbid;Uroflox;Esclebin;Amicrobin;Neofloxacin;Utin;Norfloxin;Neofloxin;Urekacin;Barotham;Renosept;Nofocin;Norfloxacin Bayvit;Norfloxacine Teva;Norfloxacine Ratiopharm;Norfloxacine EG;Noroxacine;Norflox;Uriflox;Normax;Norilet;Urotrobel;1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid;1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid;1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
Categories:
Active Pharmaceutical Ingredients > Inhibitor Drugs

Description

It is white to light yellow crystalline powder. It is odorless with slightly bitter taste. Upon exposure to the air, it can easily absorb moisture to form a hemihydrate. Its color will be deepened upon light. Solubility (mg/m1) in 25 ℃: 0.28 in water, 0.98 in methanol, 1.9 in ethanol, 5.1 in acetone, 5.5 in chloroform, 0.01 in diethyl ether, 0.15 in benzene, 0.94 in ethyl acetate, 5.1 in octanol, and 340 in glacial acetic acid. It is easily soluble in acidic or alkaline solution and slightly so

Norfloxacin Basic Attributes

Molecular Weight：

319.33

Exact Mass：

319.33

EC Number：

274-614-4

HScode：

29335990

Characteristics

PSA：

72.9

XLogP3：

2.1

Appearance：

White to yellow Crystalline Powder

Density：

1.2504 (estimate)

Melting Point：

227-228 °C

Boiling Point：

695.6°C at 760 mmHg

Flash Point：

289.9ºC

Water Solubility：

soluble in acetic acid. Also soluble in acetone or cloroform. Slightly soluble in water

Storage Conditions：

2-8°C

Toxicity：

Intravenous-rat LD50: 245 mg/kg; Oral-mouse LD50: 4000 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxides and fluoride fumes; patients taking side effects: changes in musculoskeletal function

Safety Information

Hazard category：

IRRITANT

wgk germany：

hazard class code：

20/21/22-36/37/38

safety instructions：

26-37/39-24/25

RTECS Number：

VB2005000

Marks：

Storage features：

Ventilated, low temperature and dry

Stability/Shelf Life：

Stable at normal temperatures and pressures.

Precautionary statement(s)：

P264, P280, P305+P351+P338, P310, P33, P313

Hazard Statements：

H318

Toxicity

Toxicity class：

moderately

Norfloxacin Use and Manufacturing

Pefloxacin derivative as antibacterial. Fluorinated quinolone antibacterial. It has a broad-spectrum and high-efficiency antibacterial effect, a wide range of treatment, good oral absorption, and low toxicity. It is mainly used for the treatment of urinary tract infections, biliary tract infections, and intestinal infections clinically, with remarkable curative effect.

Computed Properties

Molecular Weight:319.33
XLogP3:-1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:319.13321961
Monoisotopic Mass:319.13321961
Topological Polar Surface Area:72.9
Heavy Atom Count:23
Complexity:519
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

1-Chloro-4-nitrobenzene

Isoamyl alcohol

Tetrafluoroboric acid

Glucose

Ethyl bromide

Starch

1,2-Dichlorobenzene

Price Analysis

Make your Norfloxacin purchase based on the price and market insights! ECHEMI provides professional market insights with prices for you to make a better choice. Learn more on Norfloxacin prices .

Drug Function and Efficacy

This product is a fluoroquinolone antibacterial drug with a broad-spectrum antibacterial effect, especially high antibacterial activity against aerobic Gram-negative bacteria. It has good antibacterial activity against the following bacteria in vitro: most bacteria of the Enterobacteriaceae family, including Citrobacter, Enterobacter cloacae, Enterobacter aerogenes and other Enterobacter species, Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, Vibrio, Yersinia, etc. Norfloxacin also has antibacterial activity against multi-drug resistant bacteria in vitro. It also has good antibacterial effects on penicillin-resistant Neisseria gonorrhoeae, Haemophilus influenzae and Moraxella catarrhalis. Norfloxacin is a bactericide that acts on the A subunit of bacterial DNA helicase, inhibiting DNA synthesis and replication, leading to bacterial death.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Norfloxacin Capsules
Ingredients	Norfloxacin
Indication	1. Urine alkalinizing agents can reduce the solubility of this product in urine, leading to crystalluria and nephrotoxicity. 2. When this product is used in combination with theophylline, competitive inhibition of the cytochrome P450 binding site may lead to a significant reduction in the liver clearance of theophylline, a prolonged blood elimination half-life (t1/2β), an increase in blood drug concentration, and the appearance of symptoms of theophylline poisoning, such as nausea, vomiting, tremor, restlessness, excitement, convulsions, palpitations, etc. Therefore, theophylline blood drug concentration should be measured and the dose adjusted when used in combination. 3. Cyclosporine combined with this product can increase the blood drug concentration of the former. The blood concentration of cyclosporine must be monitored and the dose adjusted. 4. This product can enhance the anticoagulant effect of the latter when used with the anticoagulant warfarin. The patient's prothrombin time should be closely monitored when used in combination. 5. Probenecid can reduce the secretion of this product from the renal tubules by about 50%. When used in combination, it may cause toxicity due to the increased blood concentration of this product. 6. This product has an antagonistic effect with nitrofurantoin, and its combined use is not recommended. 7. Multivitamins, or other preparations containing iron or zinc ions, and antacids containing aluminum or magnesium can reduce the absorption of this product. It is recommended to avoid co-use. If it cannot be avoided, take it 2 hours before or 6 hours after taking this product. 8. Didanosine (DDI) can reduce the oral absorption of this product. Because its preparation contains aluminum and magnesium, it can chelate with fluoroquinolones, so it is not suitable for co-use. 9. This product interferes with the metabolism of caffeine, resulting in reduced caffeine clearance, prolonged blood elimination half-life (t1/2β), and possible central nervous system toxicity.
Specifications	0.1g
Manufacturer	Harbin Pharm. Group Sanchine Heihe Pharmaceutical Co., Ltd.

Norfloxacin Tablets
Ingredients	Norfloxacin
Indication	Not yet clear.
Specifications	0.1g
Manufacturer	Qinghai Pharmaceutical Co., Ltd.

Norfloxacin Capsules
Ingredients	Norfloxacin
Indication	1. Urine alkalinizing agents can reduce the solubility of this product in urine, leading to crystalluria and nephrotoxicity. 2. When this product is used in combination with theophylline, competitive inhibition of the cytochrome P450 binding site may lead to a significant reduction in the liver clearance of theophylline, a prolonged blood elimination half-life (t1/2β), an increase in blood drug concentration, and the appearance of symptoms of theophylline poisoning, such as nausea, vomiting, tremor, restlessness, excitement, convulsions, palpitations, etc. Therefore, theophylline blood drug concentration should be measured and the dose adjusted when used in combination. 3. Cyclosporine combined with this product can increase the blood drug concentration of the former. The blood concentration of cyclosporine must be monitored and the dose adjusted. 4. This product can enhance the anticoagulant effect of the latter when used with the anticoagulant warfarin. The patient's prothrombin time should be closely monitored when used in combination. 5. Probenecid can reduce the secretion of this product from the renal tubules by about 50%. When used in combination, it may cause toxicity due to the increased blood concentration of this product. 6. This product has an antagonistic effect with nitrofurantoin, and its combined use is not recommended. 7. Multivitamins, or other preparations containing iron or zinc ions, and antacids containing aluminum or magnesium can reduce the absorption of this product. It is recommended to avoid co-use. If it cannot be avoided, take it 2 hours before or 6 hours after taking this product. 8. Didanosine (DDI) can reduce the oral absorption of this product. Because its preparation contains aluminum and magnesium, it can chelate with fluoroquinolones, so it is not suitable for co-use. 9. This product interferes with the metabolism of caffeine, resulting in reduced caffeine clearance, prolonged blood elimination half-life (t1/2β), and possible central nervous system toxicity.
Specifications	0.1g
Manufacturer	Sichuan Kelun Pharmaceutical Co., Ltd.

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Registered Holders

Zhejiang Cheng Yi Pharmaceutical Co., Ltd.

China
Active
Shanghai Yurui BIOTECHNOLOGY (Anyang) Pharmaceutical Co., Ltd.

China
Active
Wanbangde Pharmaceutical Group Co., Ltd.

China
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