Cephalexin and Trimethoprim Granules

Cephalexin is a first-generation cephalosporin with an antibacterial spectrum similar to that of cephalothin, but its antibacterial activity is poorer than that of the latter. Except for Enterococcus and methicillin-resistant Staphylococci, most strains of Streptococcus pneumoniae, hemolytic Streptococcus, and Staphylococci that produce or do not produce penicillinase are sensitive to this product. This product has a good antibacterial effect on Neisseria, but Haemophilus influenzae is less sensitive to this product. This product has a certain antibacterial effect on some Escherichia coli, Proteus mirabilis, Salmonella and Shigella. The remaining Enterobacteriaceae, Acinetobacter, Pseudomonas aeruginosa, and Bacteroides fragilis are resistant to this product. Fusobacterium and Veillonella are generally sensitive to this product, and anaerobic Gram-positive cocci are moderately sensitive to this product. Trimethoprim is an antibacterial agent, and its mechanism of action is to interfere with bacterial folate metabolism.

This product is a compound preparation, containing 50 mg of cephalexin and 10 mg of trimethoprim per gram.

This product is a granule with flavoring agent and tastes sweet.

Used for infections caused by penicillin-resistant Staphylococci, Streptococci, Pneumococci, Escherichia coli, etc.

Oral administration: 2.5-5.0g (1-2 bags) each time, 4 times a day. Children can take a reduced dose or follow the doctor's advice.

1. Nausea, vomiting, diarrhea and abdominal discomfort are more common. 2. Allergic reactions such as rash and drug fever. Rarely, anaphylactic shock may occur. 3. Neurological reactions such as dizziness, diplopia, tinnitus, convulsions, etc. 4. Renal damage may occur occasionally during the use of this product. 5. Occasionally, patients have elevated serum aminotransferase and positive Coombs test. Hemolytic anemia is rare, and neutropenia and pseudomembranous colitis have also been reported. 6. Trimethoprim's interference with folic acid metabolism can produce adverse reactions in the blood system, such as leukopenia, thrombocytopenia or methemoglobin anemia. Generally, leukopenia and thrombocytopenia are mild, and can be recovered by stopping the drug in time. Folic acid preparations can also be added.

1. It is contraindicated for those who are allergic to cephalosporins or penicillin; 2. It is contraindicated for those who are allergic to trimethoprim; 3. It is contraindicated for newborns and premature infants; 4. It is contraindicated for patients with severe liver and kidney diseases; 5. It is contraindicated for patients with blood diseases; 6. It should be used with caution in pregnant and lactating women.

Precautions for children: Not for use in newborns and premature infants. Precautions for pregnancy and lactation: Use with caution in pregnant and lactating women. Precautions for the elderly: Not yet clear.

Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.

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Each gram contains 50mg of cephalexin and 10mg of trimethoprim

24 months