Levamisole Hydrochloride Suppository
Function and Efficacy
This product is the levorotatory form of tetramisole, which can selectively inhibit succinate dehydrogenase in the muscles of the worm, so that fumaric acid cannot be reduced to succinic acid, thereby affecting the anaerobic metabolism of the muscles of the worm and reducing energy production. When the worm comes into contact with it, it can depolarize the nerves and muscles, and the muscles will continue to contract and cause paralysis; the drug's cholinergic effect is conducive to the excretion of the worm. Its activity is about 1 to 2 times that of tetramisole (racemic form), but its toxic side effects are lower. In addition, the drug may have an inhibitory effect on the microtubule structure of the worm. Levamisole also has immune regulation and immune excitation functions.
Ingredients
Main ingredient: Levamisole hydrochloride Chemical name: (S)-(-)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Levamisole hydrochlorideIngredients |
This product is the levorotatory form of tetramisole, which can selectively inhibit succinate dehydrogenase in the muscles of the worm, so that fumaric acid cannot be reduced to succinic acid, thereby affecting the anaerobic metabolism of the muscles of the worm and reducing energy production. When the worm comes into contact with it, it can depolarize the nerves and muscles, and the muscles will continue to contract and cause paralysis; the drug's cholinergic effect is conducive to the excretion of the worm. Its activity is about 1 to 2 times that of tetramisole (racemic form), but its toxic side effects are lower. In addition, the drug may have an inhibitory effect on the microtubule structure of the worm. Levamisole also has immune regulation and immune excitation functions. More |
16595-80-5 | 7 |
Indication
Used to expel ascaris, hookworms, pinworms and strongyloides, etc.
Usage and Dosage
Rectal administration for pinworm and ascariasis: 50 mg for children under 1 year old, 75 mg for children under 3 years old, 100 mg for children under 5 years old, 150 mg for children under 10 years old, 1 tablet once a day, 3 consecutive days as a course of treatment. For hookworm disease, 25 mg for children aged 1-4 years old, 50 mg for children aged 5-12 years old, and 100 mg for children aged 13-15 years old, 1 tablet once a day, 3 consecutive days as a course of treatment.
Adverse Reactions
Generally mild. Symptoms include nausea, vomiting, abdominal pain, etc. A few may experience taste disorders, fatigue, dizziness, headache, joint pain, confusion, insomnia, fever, flu-like symptoms, low blood pressure, vasculitis, rash, photosensitivity dermatitis, etc. Proteinuria is occasionally seen. Some may have granulocytopenia and thrombocytopenia. A few may even have agranulocytosis (often reversible), which often occurs in patients with rheumatism or tumors. In addition, it can cause immediate and Arthus allergic reactions, which may be atopic reactions caused by stimulating T cells. Individual cases may experience ataxia, paresthesia, or blurred vision.
Precautions
It is contraindicated for patients with impaired liver and kidney function, active hepatitis, early pregnancy, or pre-existing schistosomiasis.
Drug Interactions
1. Combined with pyrantel, it can treat severe hookworm infection and improve the effect of expelling American hookworm. 2. Combined with thiabendazole, it can treat mixed intestinal nematode infection. 3. Sequential use with diethylcarbamazine citrate can treat filarial infection. 4. It should not be used in combination with tetrachloroethylene to avoid increasing its toxicity.
Storage
Keep tightly closed in a cool place.
Packaging Specification
100mg
Manufacturer
Hubei Dongxin Pharmaceutical Co., Ltd.
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Founded in:
2002-03-04 -
Address:
No. 33, Hansha Street, Guanyinzhai Town, Shashi District, Jingzhou City, Hubei Province -
Tax NO.:
9142100018186208XQ -
Registered Funds:
50 million yuan -
Website:
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Email: