The mechanism of action is to inhibit bacterial DNA helicase. It has a broad-spectrum antibacterial effect, and has strong antibacterial activity against Escherichia coli, Klebsiella and other Enterobacteriaceae negative bacilli, as well as influenza bacilli, typhoid bacilli, Shigella dysenteriae, and gonococci. It is also better than norfloxacin and pefloxacin mesylate in antibacterial effects against Pseudomonas aeruginosa, Acinetobacter, Staphylococcus aureus, Pneumococcus, alpha-hemolytic streptococci, beta-hemolytic streptococci, etc., but has little effect on pneumococci and group A streptococci. There is no cross-resistance with other antibiotics, and β-lactam, aminoglycoside, and sulfonamide resistant strains are still sensitive to this product.

Has antibacterial effect on many common pathogenic fungi

It has antibacterial and keratin-dissolving effects

Has anti-bacterial and anti-fungal effects

This product is a non-steroidal anti-inflammatory drug. Its analgesic, anti-inflammatory and antipyretic effects work by inhibiting the synthesis of prostaglandins. It is rapidly absorbed after rectal administration, and its plasma protein binding rate is higher than 99%. T1/2 is generally 13 hours. It is metabolized in the liver and excreted through the kidneys. About 95% is excreted in the urine in its original form and its conjugates.

This product is a nitroimidazole derivative that can inhibit the redox reaction of amoeba and break the nitrogen chain of the protozoa. In vitro tests have shown that when the drug concentration is 1-2 mg/L, the histolytica amoeba can undergo morphological changes in 6-20 hours and all are killed within 24 hours. When the concentration is 0.2 mg/L, the histolytica amoeba can be killed within 72 hours. This product has a strong effect of killing trichomonas, and its mechanism is unknown. Metronidazole has a killing effect on cells and anaerobic microorganisms growing under hypoxic conditions. The metabolites generated when it is reduced in the human body also have anti-anaerobic effects, inhibiting the synthesis of bacterial deoxyribonucleic acid, thereby interfering with the growth and reproduction of bacteria, and ultimately causing bacterial death.

It has a certain inhibitory effect on carrageenan-induced plantar swelling in rats, acetic acid-induced peritoneal inflammatory exudation in mice, foreign body metritis in rats, and acute bacterial prostatitis in rats; it has a certain inhibitory trend on the growth of subcutaneous cotton ball granuloma in mice; it has a certain analgesic effect on peritoneal acetic acid-induced pain and hot plate-induced pain in mice; it has the effect of improving the phagocytic function of peritoneal macrophages in mice; and it has different degrees of antibacterial effect on Escherichia coli, Proteus, Staphylococcus aureus, and Pseudomonas aeruginosa in vitro.

Preclinical pharmacological experiments show that this product has a certain inhibitory effect on carrageenan-induced swelling of the rat paw, acetic acid-induced peritoneal inflammatory exudation in mice, foreign body metritis in rats, and acute bacterial prostatitis in rats. It has a certain inhibitory effect on the growth of subcutaneous cotton ball granulomas in mice; it has a certain analgesic effect on peritoneal acetic acid-induced pain and hot plate-induced pain in mice; and it also has the effect of improving the phagocytic function of peritoneal macrophages in mice. This product has different degrees of antibacterial effect on Escherichia coli, Proteus, Staphylococcus aureus, and Pseudomonas aeruginosa in vitro.