Gentomycin Sulfate and Bismuth Carbonate Capsules

Gentamycin sulfate is an aminoglycoside drug. It has good antibacterial effects on various Gram-negative and Gram-positive bacteria. It has good effects on various Enterobacteriaceae such as Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, Enterobacter, Serratia and Pseudomonas aeruginosa. Neisseria and Haemophilus influenzae are moderately sensitive to this product. It also has certain effects on Brucella, Yersinia pestis, Acinetobacter and Campylobacter fetus. It has good antibacterial effects on about 80% of methicillin-sensitive strains of Staphylococcus (including Staphylococcus aureus and coagulase-negative Staphylococci), but methicillin-resistant strains are mostly resistant to this product. It has poor effects on Streptococcus and Streptococcus pneumoniae, and Enterococcus is mostly resistant to this product. When this product is used in combination with β-lactams, most of them can obtain synergistic antibacterial effects. Its mechanism of action is to bind to the 30S subunit of the bacterial ribosome and inhibit the synthesis of bacterial proteins. In recent years, the number of gram-negative bacteria resistant to gentamicin has increased significantly. Bismuth subcarbonate can protect the gastrointestinal mucosa from acidosis and astringency, and can achieve antidiarrheal effects by reducing intestinal irritation, preventing excessive dehydration and water-salt metabolism disorders.

This product is a compound preparation, whose components are 40 mg (40,000 units) of gentamicin sulfate (calculated as gentamicin) and 600 mg of bismuth subcarbonate per tablet.

This product is a capsule, and the contents are white or slightly yellowish powder or granules.

Suitable for chronic ulcerative enteritis, dysentery and acute enteritis.

Oral administration. Adults take 2 to 3 capsules at a time, 3 times a day; children take 1 capsule at a time, 3 times a day. For continuous medication, one course of treatment should not exceed 10 days.

1. Nausea, loss of appetite, vomiting, abdominal distension and other gastrointestinal symptoms and skin rash, serum aminotransferase elevation, etc. are rare. 2. Hearing loss, tinnitus or fullness in the ears (ototoxicity), hematuria, significantly reduced urination frequency or decreased urine volume, loss of appetite, extreme thirst (nephrotoxicity), unsteady gait, dizziness (ototoxicity, vestibular effects), dyspnea, drowsiness, extreme weakness (neuro-muscle blockade) are occasionally seen. 3. Long-term use of large doses can cause constipation, alkalosis and malabsorption syndrome.

Patients who are allergic to this product or other aminoglycoside antibiotics are contraindicated.

Precautions for children: Because this product has potential ototoxicity and nephrotoxicity, it should be used with caution in children. Precautions for pregnancy and lactation: Because the absorbed part of this product can enter the fetal circulation through the placenta, pregnant women should use it with caution. Lactating women should suspend breastfeeding during medication. Precautions for the elderly: Because this product has potential ototoxicity and nephrotoxicity, it should be used with caution in elderly patients.

1. When used in combination with other aminoglycosides or used in sequence, it may increase the possibility of ototoxicity, nephrotoxicity and neuromuscular blocking effects. When used in combination with neuromuscular blockers, it may aggravate neuromuscular blocking effects. 2. When used in combination with capreomycin, cisplatin, ethacrynic acid, furosemide or vancomycin or used in sequence, it may increase the possibility of ototoxicity and nephrotoxicity. 3. When used in combination with cephalothin, it may increase nephrotoxicity. 4. When used in combination with polymyxins or used in sequence, it may increase nephrotoxicity and neuromuscular blocking effects. 5. Other nephrotoxic and ototoxic drugs should not be used in combination with this product or used in sequence to avoid aggravating nephrotoxicity or ototoxicity. 6. When used in combination with large doses of anti-pseudomonas penicillins (carbenicillin, ticarcillin, mezlocillin, azlocillin, piperacillin), gentamicin may be inactivated and should be used separately.

Keep away from light and store in sealed container.

Gentamycin sulfate (calculated as gentamicin) 40 mg, bismuth subcarbonate 0.6 g

24 months

Jilin Aodong Pharmaceutical Industry Group Yanji Co., Ltd.

• Founded in:

  1998-09-24

• Address:

  No. 389, Changbai Road, High-tech Development Zone, Yanji City, Jilin Province

• Tax NO.:

  912224017022762985

• Registered Funds:

  161.526808 yuan

• Email:

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