Lidocaine Hydrochloride Injection

This product is an amide local anesthetic. After blood absorption or intravenous administration, it has obvious biphasic effects of excitation and inhibition on the central nervous system, and there may be no precursor excitation. When the blood concentration is low, analgesia and sleepiness occur, and the pain threshold increases; with increasing doses, the effect or toxicity increases, and there is an anticonvulsant effect at sub-toxic blood concentrations; convulsions may occur when the blood concentration exceeds 5?gml-1. At low doses, this product can promote the outflow of K in myocardial cells, reduce myocardial autonomy, and have an anti-ventricular arrhythmia effect; at therapeutic doses, it has no obvious effect on the electrical activity of myocardial cells, atrioventricular conduction, and myocardial contraction; further increases in blood concentrations can cause a slowing of cardiac conduction velocity, atrioventricular conduction block, inhibition of myocardial contractility, and a decrease in cardiac output.

The main ingredients of this product: lidocaine hydrochloride. Its chemical name is: N-(dichloroxyl)-2-(diethylamino)acetamide hydrochloride monohydrate. Structural formula: (see lidocaine hydrochloride sustained-release pills) Molecular formula: C14H22N20HClH20 Molecular weight: 288.82.

This product is a colorless clear liquid.

This product is a local anesthetic and antiarrhythmic drug. It is mainly used for infiltration anesthesia, epidural anesthesia, surface anesthesia (including mucosal anesthesia during thoracoscopy or abdominal surgery) and nerve conduction block. This product can also be used for ventricular premature beats and ventricular tachycardia after acute myocardial infarction, and can also be used for ventricular arrhythmias caused by digitalis poisoning, cardiac surgery and cardiac catheterization. This product is usually ineffective for supraventricular arrhythmias.

Common dosage for anesthesia in adults: 1. Surface anesthesia: 2% to 4% solution, no more than 100 mg at a time. When injecting, the dosage should not exceed 4.5 mg/kg (without adrenaline) or 7 mg/kg per injection (with adrenaline at a concentration of 1:200000); 2. Sacral block for labor analgesia: use 1.0% solution, limited to 200 mg; 3. Epidural block: 1.5% to 2.0% solution, 250 to 300 mg for thoracolumbar segment; 4. Infiltration anesthesia or intravenous regional block: use 0.25% to 0.5% solution, 50 to 300 mg; 5. Peripheral nerve block: brachial plexus (unilateral) with 1.5% solution, 250 to 300 mg; 2% solution for dentistry, 20 to 100 mg; 1% solution for intercostal nerve (each branch).

1. This product can act on the central nervous system, causing adverse reactions such as drowsiness, paresthesia, muscle tremor, convulsion, coma and respiratory depression; 2. It can cause hypotension and bradycardia. If the blood concentration is too high, it can cause atrial conduction velocity slowing, atrioventricular conduction block, inhibition of myocardial contractility and decreased cardiac output.

1. It is contraindicated for patients who are allergic to local anesthetics. 2. It is contraindicated for patients with Adams-Stokes syndrome (acute cardiogenic ischemic syndrome), preexcitation syndrome, and severe heart block (including sinoatrial, atrioventricular and intraventricular block) to use intravenously.

Precautions for children: The drug may cause poisoning in neonates, and the half-life of premature infants is longer than that of normal infants (3.16 hours: 1.8 hours). Precautions for pregnancy and lactation: This product crosses the placenta and binds to fetal proteins more than adults. Precautions for the elderly: The dosage should be adjusted according to the needs and tolerance of the elderly. The dosage should be halved for patients over 70 years old.

Combination with cyclosporine may excessively suppress immunity. Do not use with blood products and lipid fluids.

Keep tightly closed.

5ml:0.1g

Shanxi JINXIN DOUBLE-CRANE Pharmaceutical Co., Ltd.

• Founded in:

  2001-12-14

• Address:

  Sanlidun, North of Xia County, Yuncheng City, Shanxi Province

• Tax NO.:

  911408287281430205

• Registered Funds:

  164.191 million yuan

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