Rifampicin Capsules

Rifampicin is a semi-synthetic broad-spectrum antibiotic of the rifamycin class, which has antibacterial activity against a variety of pathogenic microorganisms. The drug has obvious bactericidal effects on Mycobacterium tuberculosis and some non-tuberculous mycobacteria (including Mycobacterium leprae, etc.) both inside and outside the host cells. Rifampicin has good antibacterial effects on aerobic Gram-positive bacteria, including enzyme-producing strains and methicillin-resistant strains of Staphylococcus aureus, Streptococcus pneumoniae, other Streptococcus, Enterococcus, Listeria, Bacillus anthracis, Clostridium perfringens, Corynebacterium diphtheriae, anaerobic cocci, etc. It also has high antibacterial activity against aerobic Gram-negative bacteria such as Neisseria meningitidis, Haemophilus influenzae, and Neisseria gonorrhoeae. Rifampicin also has a good effect on Legionella, and has inhibitory effects on pathogens such as Chlamydia trachomatis, lymphogranuloma venereum, and psittacosis. Bacteria are very sensitive to rifampicin.

The main ingredient of this product is rifampicin, and its chemical name is 3-[[(4-methyl-1-piperazinyl)imino]methyl]-rifamycin.

This product is a capsule containing bright red or dark red crystalline powder.

1 This product is used in combination with other anti-tuberculosis drugs for the initial and retreatment of various tuberculosis diseases, including the treatment of tuberculous meningitis. 2 This product is used in combination with other drugs to treat leprosy and non-tuberculous mycobacterial infections. 3 This product can be used in combination with vancomycin (intravenous) for severe infections caused by methicillin-resistant Staphylococci. The combination of rifampicin and erythromycin is used for severe Legionella infections. 4 It is used for asymptomatic carriers of Neisseria meningitidis to eliminate Neisseria meningitidis in the nasopharynx; but it is not suitable for the treatment of Neisseria meningitidis infections.

1. For anti-tuberculosis treatment of adults: Oral, 0.45g-0.60g per day, taken on an empty stomach, not more than 1.2g per day; for children over 1 month old, 10-20mg/kg per day, taken on an empty stomach, not more than 0.6g per day. 2. For carriers of Neisseria meningitidis: 5mg/kg per day, once every 12 hours for 2 consecutive days; for children over 1 month old, 10mg/kg per day, once every 12 hours for 4 consecutive days. 3. For elderly patients, oral, 10mg/kg per day, taken on an empty stomach.

1 Gastrointestinal reactions are the most common. Gastrointestinal reactions such as anorexia, nausea, vomiting, upper abdominal discomfort, and diarrhea may occur after oral administration of this product, with an incidence of 1.7% to 4.0%, but they are all tolerable. 2 Hepatotoxicity is the main adverse reaction of this product, with an incidence of about 1%. In the first few weeks of treatment, a small number of patients may experience elevated serum aminotransferases, hepatomegaly, and jaundice. Most of these are asymptomatic transient elevations of serum aminotransferases, which can recover on their own during the course of treatment. The elderly, alcoholics, malnourished people, those with pre-existing liver disease or other factors causing abnormal liver function are more likely to develop the disease. 3 Allergic reactions: Flu-like syndrome may occasionally occur after high-dose intermittent therapy, manifested by chills, chills, fever, malaise, and breathing.

1. Patients who are allergic to this product or rifamycin antibiotics are contraindicated. 2. Patients with severe liver dysfunction, biliary obstruction and pregnant women within 3 months are contraindicated.

Precautions for children: The safety of this product for children under 5 years old has not been established. Precautions for pregnancy and lactation: 1. Rifampicin can cross the placenta and has caused teratogenesis in animal experiments. Although there are no reports of teratogenesis in humans, there is currently insufficient information to indicate that it can be safely used during pregnancy. 2. Rifampicin can be excreted in breast milk. Lactating women should fully weigh the pros and cons before deciding whether to use the drug. Precautions for the elderly: Elderly patients have decreased liver function and the dosage should be reduced as appropriate.

1 Drinking alcohol can increase the incidence of rifampicin hepatotoxicity and increase the metabolism of rifampicin. The rifampicin dose needs to be adjusted, and the patient should be closely observed for liver toxicity. 2 Para-aminosalicylate can affect the absorption of this product, resulting in a decrease in its blood concentration; if combined use is necessary, the interval between taking the two should be at least 6 hours. 3 The risk of hepatotoxicity increases when this product is used in combination with isoniazid, especially in patients with pre-existing liver damage and patients with rapid acetylation of isoniazid. 4 The combination of rifampicin and ethionamide can aggravate its adverse reactions. 5 Chlorophenazone can reduce the absorption of rifampicin, delay the peak time and prolong the half-life. 6 Rifampicin and miconazole or

Sealed, store in a dark and dry place.

0.15g

24 months.

Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.

• Founded in:

  2001-11-30

• Address:

  Luoqi Road, Linyi High-tech Industrial Development Zone, Shandong Province

• Tax NO.:

  913700002658705037

• Registered Funds:

  60.96 million yuan

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