Valacyclovir Hydrochloride Tablets

This product is a prodrug of acyclovir. It is rapidly absorbed after oral administration and quickly converted into acyclovir in the body. Its antiviral effect is exerted by acyclovir. After acyclovir enters the herpes infected cells, it competes with deoxynucleoside for viral thymidine kinase or cell kinase. The drug is phosphorylated into activated acyclosine triphosphate, which competes with deoxyguanine triphosphate for viral DNA polymerase as a substrate for viral replication, thereby inhibiting viral DNA synthesis and showing antiviral effect. The antiviral activity of this product in vivo is better than that of acyclovir, and its therapeutic index for herpes simplex virus type I and type II is 42.91% and 30.13% higher than that of acyclovir, respectively. It also has a high efficacy against varicella zoster virus and has low toxicity to mammalian host cells. The LD50 of rats and mice administered by oral gavage is 4.4g/kg and 1.51g/kg, respectively. Since this product is quickly converted into acyclovir in the body, its metabolites do not accumulate in the body. In long-term toxicity tests at different stages, this product has the same safety as acyclovir.

The main ingredient of this product is valacyclovir hydrochloride.

This product is a film-coated tablet, which appears white or off-white after removing the film coating.

It is used to treat varicella zoster and herpes simplex virus infections of type I and type II, including primary and recurrent genital herpes virus infections. This product can be used for all indications of acyclovir.

Oral administration, 0.3g each time, twice a day, before meals on an empty stomach. For herpes zoster, take the medicine continuously for 10 days. For herpes simplex, take the medicine continuously for 7 days.

Occasionally, dizziness, headache, joint pain, nausea, vomiting, diarrhea, stomach discomfort, loss of appetite, thirst, leukocytopenia, slight increase in proteinuria and urea nitrogen, skin itching, etc. may occur. Acne, insomnia, and menstrual disorders may occur occasionally with long-term administration.

It is contraindicated for those who are allergic to this product and acyclovir.

Precautions for children: The safety and effectiveness of the drug for children have not yet been determined. Precautions for pregnancy and lactation: Acyclovir can pass through the placenta, and pregnant women need to weigh the pros and cons of using the drug. The concentration of acyclovir in breast milk is 0.6 to 4.1 times the blood concentration, so lactating women should use it with caution. Precautions for the elderly: Due to the decline of physiological renal function, the dosage and medication interval of this product need to be adjusted.

1. Combination with zidovudine can cause nephrotoxicity, manifested as deep lethargy and fatigue. 2. Competitive inhibition of organic acid secretion with probenecid. Combination with probenecid can slow down the excretion of acyclovir, prolong the half-life, and cause drug accumulation in the body.

Sealed, store in a dry place.

0.3g (calculated as valacyclovir)

36 months.

Sichuan Wanglintang Pharmaceutical Co., Ltd.

• Founded in:

  2001-06-03

• Address:

  No. 5 Baiguo Road, Fushi Town, Fushun County, Zigong City, Sichuan Province

• Tax NO.:

  91510322204302713C

• Registered Funds:

  15.5 million yuan

• Email:

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