Spironolactone tablets

It has a similar chemical structure to aldosterone, competitively inhibits aldosterone in the distal convoluted tubule and collecting duct, thereby interfering with the effect of aldosterone on promoting sodium reabsorption in the above-mentioned parts. It promotes the excretion of Na+ and Cl- to produce diuresis. Because the Na+K+ exchange mechanism is inhibited, the excretion of potassium is reduced, so it is a potassium-retaining diuretic. This product is a low-efficiency diuretic and has a therapeutic effect on edema caused by secondary aldosterone elevation.

The main ingredient is spironolactone, whose chemical name is 17beta;-hydroxy-3-oxo-7alpha;-(acetylthio)-17alpha;-pregnane-4-ene-21-carboxylic acid gamma;-lactone.

This product is white tablets.

Aldosterone antagonist. Used as an auxiliary diuretic for edema caused by liver cirrhosis, ascites, nephrotic syndrome, heart failure, etc.

Oral administration: 1 tablet (12 mg) at a time, 3 to 4 times a day.

1. Hyperkalemia: It is easy to occur especially in case of renal insufficiency or when taking potassium supplements. 2. Long-term and large-scale use may cause breast enlargement and impotence in men; irregular menstruation and hirsutism in women, which disappear after stopping the drug. 3. Hyponatremia: It is less common. 4. Gastrointestinal reactions: Nausea, vomiting, stomach pain, diarrhea, etc. 5. Occasionally, headache and rash may occur.

Contraindicated in patients with hyperkalemia.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Use with caution in pregnant and lactating women. Precautions for the elderly: Elderly people are more likely to develop hyperkalemia and excessive diuresis when taking the drug.

1. Adrenocortical hormones, especially those with strong mineralocorticoid effects, and adrenocorticotropic hormone can weaken the diuretic effect of this drug and antagonize the potassium retention effect of this drug. 2. Estrogen can cause water and sodium retention, thereby weakening the diuretic effect of this drug. 3. Non-steroidal anti-inflammatory analgesics, especially indomethacin, can reduce the diuretic effect of this drug, and the renal toxicity increases when used in combination. 4. Sympathomimetic drugs reduce the antihypertensive effect of this drug. 5. Dopamine enhances the diuretic effect of this drug. 6. When used in combination with drugs that cause a decrease in blood pressure, both the diuretic and antihypertensive effects are enhanced. 7. When used in combination with the following drugs, the chance of hyperkalemia increases, such as potassium-containing drugs, stored blood (containing 30mmol/L of potassium, such as potassium up to 65mmol/L if stored for more than 10 days), angiotensin converting enzyme inhibitors, angiotensin II receptor antagonists and cyclosporine A. 8. When used in combination with glucose insulin solution, alkali agents, and sodium-type potassium-lowering exchange resins, the chance of hyperkalemia decreases. 9 This drug prolongs the half-life of digoxin. 10 Metabolic acidosis is likely to occur when used in combination with ammonium chloride. 11 When used in combination with nephrotoxic drugs, nephrotoxicity increases. 12 Sodium carbenoxolone and licorice preparations have aldosterone-like effects and can reduce the diuretic effect of this drug.

Sealed, store in a dry place.

12mg

30 months

Beijing Haiwang Zhongxin Pharmaceutical Co., Ltd.

• Founded in:

  1990-08-14

• Address:

  No. 1, Qiangyun Road, Economic Development Zone, Miyun District, Beijing

• Tax NO.:

  91110228102644755T

• Registered Funds:

  100 million yuan

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