Potassium Chloride Granules
Function and Efficacy
Potassium is the main cation in cells, with a concentration of 150-160 mmol/L, while the main cation outside cells is sodium ions, with a potassium concentration of only 3.5-5.0 mmol/L. The body mainly relies on Na+, K+, and ATPase on the cell membrane to maintain the difference in K+ and Na+ concentrations inside and outside cells. The acid-base balance in the body has an impact on potassium metabolism. For example, when acidosis occurs, H enters the cell. In order to maintain the potential difference inside and outside the cell, K+ is released outside the cell, causing or aggravating hyperkalemia. Metabolic disorders can also affect acid-base balance. The normal potassium ion concentration and concentration difference inside and outside cells are closely related to certain functions of cells, such as carbohydrate metabolism, glycogen storage and protein metabolism, excitability and conductivity of nerves and muscles including myocardium, etc.
Ingredients
The main ingredient is potassium chloride.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Potassium chlorideIngredients |
Potassium is the main cation in cells, with a concentration of 150-160 mmol/L, while the main cation outside cells is sodium ions, with a potassium concentration of only 3.5-5.0 mmol/L. The body mainly relies on Na+, K+, and ATPase on the cell membrane to maintain the difference in K+ and Na+ concentrations inside and outside cells. The acid-base balance in the body has an impact on potassium metabolism. For example, when acidosis occurs, H enters the cell. In order to maintain the potential difference inside and outside the cell, K+ is released outside the cell, causing or aggravating hyperkalemia. Metabolic disorders can also affect acid-base balance. The normal potassium ion concentration and concentration difference inside and outside cells are closely related to certain functions of cells, such as carbohydrate metabolism, glycogen storage and protein metabolism, excitability and conductivity of nerves and muscles including myocardium, etc. More |
7447-40-7 | 38 |
Indication
1. Treatment of hypokalemia, hypokalemia caused by various reasons, such as insufficient food intake, vomiting, severe diarrhea, use of potassium-excreting diuretics, hypokalemic familial periodic paralysis, long-term use of glucocorticoids and supplementation of hypertonic glucose, etc.; 2. Prevention of hypokalemia, when the patient has potassium loss, especially if hypokalemia is harmful to the patient (such as patients taking digitalis drugs), preventive potassium salt supplementation is required. Such as eating very little, severe or chronic diarrhea, long-term use of adrenocortical hormones, potassium-losing nephropathy, Bartter syndrome, etc.; 3. Frequent, multifocal premature beats or rapid arrhythmias caused by digitalis poisoning.
Usage and Dosage
Oral potassium salts are used to treat mild hypokalemia or as preventive medication. The usual dose for adults is 0.5-1g (6.7-13.4mmol) each time, dissolved in warm water and taken 1-3 times a day, after meals, and the dose is adjusted according to the condition. The maximum daily dose for adults is 6g (80mmol).
Adverse Reactions
1. Oral administration may cause gastrointestinal irritation symptoms, such as nausea, vomiting, throat discomfort, chest pain (esophageal irritation), abdominal pain, diarrhea, and even peptic ulcer and bleeding. This is more likely to occur when the patient is fasting, taking a large dose, or has existing gastrointestinal diseases. 2. Patients with existing renal impairment should be aware of the occurrence of hyperkalemia.
Precautions
Contraindicated in patients with hyperkalemia.
Drug Interactions
1. Adrenal glucocorticoids, especially those with more obvious mineralocorticoid effects, adrenal mineralocorticoids and adrenocorticotropic hormone (ACTH), can promote urinary potassium excretion, and when used together, the efficacy of potassium salts is reduced. 2. Anticholinergic drugs can aggravate the gastrointestinal irritation of oral potassium salts, especially potassium chloride. 3. Non-steroidal anti-inflammatory analgesics aggravate the gastrointestinal reactions of oral potassium salts. 4. When stored blood (30mmol/L of potassium for less than 10 days of storage, 65mmol/L for more than 10 days of storage), potassium-containing drugs and potassium-sparing diuretics are used together, the chance of hyperkalemia increases, especially in patients with renal damage. 5. Angiotensin-converting enzyme inhibitors and cyclosporine A can inhibit aldosterone secretion and reduce urinary potassium excretion, so hyperkalemia is prone to occur when used together. 6. Heparin can inhibit the synthesis of aldosterone and reduce urinary potassium excretion, so hyperkalemia is prone to occur when used together. In addition, heparin can increase the chance of gastrointestinal bleeding. 7. Sustained-release potassium salt can inhibit the intestinal absorption of vitamin B12.
Storage
Keep tightly closed.
Packaging Specification
1.6g (equivalent to 0.524g potassium)
Manufacturer
Wuhan Taifu Pharmaceutical Co., Ltd.
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Founded in:
1998-05-27 -
Address:
Dongshan Town, Dongxihu District, Wuhan City, Hubei Province -
Tax NO.:
9142010070714493X5 -
Registered Funds:
44 million yuan -
Website:
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Email: