Fleroxacin Tablets

This product is a quinolone antibacterial drug, which has strong antibacterial effect on Gram-negative bacteria, including Escherichia coli, Klebsiella pneumoniae, Proteus, Salmonella typhi, Salmonella paratyphi, Shigella, Enterobacter cloacae, Enterobacter aerogenes, Citrobacter, Serratia marcescens, Pseudomonas aeruginosa, Neisseria meningitidis, Haemophilus influenzae, Moracata, Legionella pneumophila, Neisseria gonorrhoeae, etc. It also has moderate antibacterial effect on Gram-positive cocci such as Staphylococcus and hemolytic Streptococcus. The mechanism of action of this product is to inhibit the bacterial DNA gyrase and thus kill bacteria.

The main ingredient of this product is fleroxacin, whose chemical name is 6,8-difluoro-1-(2-fluoroethyl)1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid. Molecular formula: C17H18F3N3O3, molecular weight: 369.34.

This product is a white or off-white tablet; or a film-coated tablet, which appears white or off-white after removing the coating.

It can be used for respiratory system infections such as acute bronchitis, acute exacerbation of chronic bronchitis and pneumonia caused by bacteria sensitive to this product; urogenital system infections such as cystitis, pyelonephritis, prostatitis, epididymitis, gonorrhea Neisseria urethritis; digestive system infections such as typhoid Salmonella infection and bacterial dysentery; skin and soft tissue infections, bone infections, abdominal infections and pelvic infections, etc.

Oral administration, 0.2-0.4 g per day, divided into 1-2 doses. The general course of treatment is 7-14 days.

Adverse drug reactions occur in a small number of patients, which may include: 1. Digestive tract reactions: upper abdominal discomfort, nausea and vomiting, loss of appetite, etc. 2. Nervous system reactions: dizziness, headache, excitement, insomnia, etc., which can be treated with symptomatic drugs, and generally the drug should not be discontinued. 3. Occasionally, transaminase is elevated.

1. Patients who are allergic to this product or quinolone drugs are prohibited from using this product. 2. Pregnant women, lactating women and patients under 18 years old are prohibited from using this product.

Precautions for children: Fluoroquinolones can cause permanent damage to the cartilage of weight-bearing joints in dogs, leading to lameness, and can also cause arthritis in several other underage animals, so they are contraindicated in patients under 18 years of age. In infections caused by multidrug-resistant bacteria, when the bacteria are only sensitive to fluoroquinolones, this product can only be used in children after weighing the pros and cons. Precautions for pregnancy and lactation: Fluoroquinolones can pass through the blood-placental barrier and can be secreted into breast milk, and their concentration is close to the blood drug concentration, so they are contraindicated for pregnant and lactating women. Precautions for the elderly: Elderly patients have reduced renal function, and the dosage should be reduced as appropriate.

1. The aluminum and magnesium contained in didanosine (DDI) preparations can chelate with fluoroquinolones and should not be used together. 2. Urine alkalinizers can reduce the solubility of this product in urine, leading to crystalluria and nephrotoxicity. 3. Probenecid can delay the excretion of this product, increase the blood concentration of this product and produce toxicity. 4. Antacids containing aluminum or magnesium can reduce the oral absorption of this product. It is recommended to avoid taking them together. If it cannot be avoided, it is recommended to take it 2 hours before or 6 hours after taking this product.

Keep in a light-proof and airtight container.

0.1g

36 months

Topfond Pharmaceutical Co., Ltd.

• Founded in:

  2013-11-13

• Address:

  No. 2 Guangming Road, Yicheng District, Zhumadian City

• Tax NO.:

  91411700083473072R

• Registered Funds:

  420 million yuan

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