Phenobarbital tablets

Phenobarbital.

This product is white tablets.

Common dosage for adults: hypnotic, 30-100 mg, taken once at night; sedative, 15-30 mg at a time, 2-3 times a day; anticonvulsant, 90-180 mg per day, which can be taken once at night, or 30-60 mg each time, three times a day; the maximum dose is 250 mg at a time, 500 mg a day; anti-hyperbilirubinemia, 30-60 mg at a time, three times a day.

1. The most common adverse reaction when used for anti-epileptic is sedation, but as the course of treatment continues, its sedative effect gradually becomes less obvious; 2. It may cause subtle emotional changes and cognitive and memory defects; 3. Long-term use may occasionally cause folic acid deficiency and hypocalcemia; 4. Megaloblastic anemia and osteomalacia are rare; 5. Large doses may produce nystagmus, ataxia and severe respiratory depression; 6. About 1% to 3% of patients using this product have skin reactions, the most common of which are various rashes. In severe cases, exfoliative dermatitis and erythema multiforme (or Stevens-Johnson syndrome) may occur, and toxic epidermal necrosis is extremely rare; 7. There are reports of hepatitis and liver dysfunction in users; 8. Long-term use may lead to drug dependence, and withdrawal is prone to occur after discontinuation of the drug.

Contraindicated in the following situations: severe pulmonary insufficiency, cirrhosis, history of porphyria, anemia, history of asthma, uncontrolled diabetes, allergies, etc.

Precautions for children: Common dosage for children: medication should be individualized, sedative, 2mg/Kg per body weight, or 60mg/m2 per body surface area, 2-3 times a day; anticonvulsant, 3-5mg/Kg per body weight; anti-hyperbilirubinemia, 5-8mg/Kg per body weight, oral administration in divided doses, effective in 3-7 days. Or according to doctor's advice. Precautions for pregnancy and lactation: This drug can pass through the placenta. Long-term use during pregnancy can cause dependence and neonatal withdrawal syndrome; may cause neonatal bleeding due to reduced vitamin K content; use in late pregnancy or delivery can cause respiratory depression in newborns (especially premature infants) due to immature fetal liver function; may cause teratogenic effects on the fetus. Use during lactation can cause central nervous system depression in infants. Precautions for the elderly: The common dosage of this drug can cause excitement, neurosis or depression, so the dosage should be smaller.

1. This product is a liver drug enzyme inducer, which increases the activity of drug enzymes. Long-term use of the drug not only accelerates its own metabolism, but also accelerates the metabolism of other drugs. For example, long-term use of barbiturates before anesthesia with halothane, enflurane, methoxyflurane and other preparations may increase the metabolites of anesthetics and increase the risk of liver toxicity. When barbiturates are used simultaneously with ketamine (Ketamine), especially large doses of intravenous administration, the risk of hypotension and respiratory depression increases; 2. When used in combination with oral anticoagulants, the effect of the latter can be reduced. This is due to the induction of liver microsomal enzymes, which accelerate the metabolism of anticoagulants. The prothrombin time should be measured regularly to determine whether to adjust the dosage of anticoagulants; 3. When used in combination with oral contraceptives or estrogens, the reliability of contraceptives can be reduced, because the induction of enzymes can make

seal.

30mg*100s

24 months

Beijing Haiwang Zhongxin Pharmaceutical Co., Ltd.

• Founded in:

  1990-08-14

• Address:

  No. 1, Qiangyun Road, Economic Development Zone, Miyun District, Beijing

• Tax NO.:

  91110228102644755T

• Registered Funds:

  100 million yuan

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