Diclofenac Potassium Tablets

Diclofenac sodium is a non-steroidal anti-inflammatory analgesic derived from phenylacetic acid. Its mechanism of action is to inhibit the activity of cyclooxygenase, thereby blocking the conversion of arachidonic acid to prostaglandins. At the same time, it can also promote the combination of arachidonic acid with triglycerides, reduce the concentration of free arachidonic acid in cells, and indirectly inhibit the synthesis of leukotrienes. Diclofenac sodium is one of the strongest non-steroidal anti-inflammatory drugs. Its inhibitory effect on prostaglandin synthesis is stronger than that of aspirin and indomethacin. Non-clinical toxicology study: Oral administration of diclofenac sodium to rats at 2 mg/kg per day, long-term observation, no increase in tumor incidence was found. In a two-year study on mice, 2 mg/kg was used daily, and no tumor-prone tendency was found. Various mutation studies have not found that diclofenac sodium induces gene mutations. Rats were given 4 mg/kg per day, and no infertility occurred in both males and females.

The main ingredient of this product is diclofenac potassium.

This product is a film-coated tablet, which appears white or off-white after removing the film coating.

1. Use with caution in patients with gastrointestinal diseases, gastrointestinal ulcers, and liver damage. 2. Use with caution in patients with symptoms or history of heart or kidney damage, elderly patients, patients taking diuretics, and patients with extracellular fluid loss due to any reason. 3. Individual patients who need long-term treatment should have their liver function and blood count checked regularly, and this product should be discontinued when liver damage occurs. 4. Patients with a history of vertigo or other central nervous system diseases should not drive or operate machinery while taking this product. 5. Attention should be paid to the dosage and adverse reactions of this product when used in combination with lithium preparations, digoxin preparations, potassium-sparing diuretics, anticoagulants, hypoglycemic drugs, and methotrexate. 6. The dosage of this product should be reduced in elderly patients with weak constitution and low body weight. 7. Use with caution in pregnant women.

Oral administration, before meals. Adults, 100-150 mg/day; patients with mild symptoms and children over 14 years old, 75-100 mg/day, taken in 2-3 times. For primary dysmenorrhea, the general dose is 50-150 mg/day, which can be increased to the maximum dose of 200 mg/day according to the condition, or as directed by the doctor.

1. Occasionally, there may be upper abdominal pain, nausea, vomiting, diarrhea, abdominal cramps, indigestion, abdominal bloating, and anorexia. Rarely, there may be gastrointestinal bleeding, hematemesis, melena, gastrointestinal ulcer, perforation, and bloody diarrhea. 2. Occasionally, there may be headache, dizziness, and vertigo. Rarely, there may be drowsiness. 3. Occasionally, there may be rash. Rarely, there may be urticaria. 4. Occasionally, there may be an increase in serum aminotransferase (SGOT, SGPT), and rarely, there may be hepatitis. 5. Rarely, there may be allergic reactions, such as asthma. 6. Rarely, there may be edema.

1. Patients with peptic ulcers are prohibited from using this product. 2. Patients who are allergic to this product or other nonsteroidal anti-inflammatory drugs are prohibited from using this product. 3. Patients with asthma, urticaria or acute rhinitis caused by acetylsalicylic acid or other prostaglandin synthase inhibitors are prohibited from using this product.

Precautions for children: This product is not recommended for children under 14 years old. Precautions for pregnancy and lactation: This product can cross the placenta. Animal experiments showed toxicity to fetal mice, but it was not teratogenic. It is forbidden for pregnant and lactating women. Precautions for the elderly: This product can cause or aggravate gastrointestinal bleeding, gastric ulcers and perforations in the elderly. It should be used with caution in elderly patients with liver and kidney damage, elderly patients taking diuretics or elderly patients with extracellular fluid loss.

Diclofenac sodium is a non-steroidal anti-inflammatory analgesic derived from phenylacetic acid. Its mechanism of action is to inhibit the activity of cyclooxygenase, thereby blocking the conversion of arachidonic acid to prostaglandins. At the same time, it can also promote the combination of arachidonic acid with triglycerides, reduce the concentration of free arachidonic acid in cells, and indirectly inhibit the synthesis of leukotrienes. Diclofenac sodium is one of the strongest non-steroidal anti-inflammatory drugs. Its inhibitory effect on prostaglandin synthesis is stronger than that of aspirin and indomethacin. Non-clinical toxicology study: Oral administration of diclofenac sodium to rats at 2 mg/kg per day, long-term observation, no increase in tumor incidence was found. In a two-year study on mice, 2 mg/kg was used daily, and no tumor-prone tendency was found. Various mutation studies have not found that diclofenac sodium induces gene mutations. Rats were given 4 mg/kg per day, and no infertility occurred in both males and females.

Keep away from light and store in sealed container.

50 mg

24 months

Jiangsu Lianshui Pharmaceutical Co., Ltd.

• Founded in:

  1999-05-21

• Address:

  No. 18, Hongri Avenue, Lianshui Economic Development Zone

• Tax NO.:

  91320826139830519D

• Registered Funds:

  80 million yuan

• Email:

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