Metronidazole capsules

Metronidazole has a strong antibacterial effect on most anaerobic bacteria, but has no effect on aerobic bacteria and facultative anaerobes. The antibacterial spectrum includes Bacteroides fragilis and other Bacteroides, Fusobacterium, Clostridium perfringens, Eubacterium, Veillonella, Peptococcus and Peptostreptococcus. Its bactericidal concentration is slightly higher than the inhibitory concentration. In addition, it also has a strong killing effect on amoeba and Trichomonas. The bactericidal mechanism of metronidazole has not been fully elucidated. The nitroreductase of anaerobic bacteria plays an important role in the energy metabolism of sensitive strains. The nitro group of this product is reduced to a cytotoxin, which acts on the DNA metabolism process of bacteria and promotes cell death. The mechanism of anti-amoeba is to inhibit its redox reaction and break the nitrogen chain of the protozoa.

The main ingredient of this product is: metronidazole.

This product is in the form of capsules.

1. It is used for various anaerobic infections, such as sepsis, endocarditis, empyema, lung abscess, abdominal infection, pelvic infection, gynecological infection, bone and joint infection, meningitis, brain abscess, skin and soft tissue infection, antibiotic-related enteritis caused by Clostridium difficile, Helicobacter pylori-related gastritis or peptic ulcer, periodontal infection and Gardner vaginitis, etc. It can also be used as a preventive drug for certain contaminated or potentially contaminated surgeries, such as colorectal elective surgery, etc.; 2. It can also be used to treat intestinal and extraintestinal amebiasis (such as amoebic liver abscess, thoracic amebiasis, etc.), vaginal trichomoniasis, balantidiasis, cutaneous leishmaniasis, dracunculiasis, giardiasis, etc.

Oral. Common dosage for adults: 1. Anaerobic infection: 0.5g once, 3 times a day, for a course of 7 days or longer. The maximum daily dose should not exceed 4g. 2. Intestinal infection: 0.5g once, 3 times a day. 3. Antibiotic-related enteritis: 0.5g once, 3 to 4 times a day. 4. Helicobacter pylori-related gastritis and peptic ulcer: 0.5g once, 3 times a day, combined with other antibiotics, for a course of 7 to 14 days. 5. Protozoan infection: (1) Intestinal amebiasis: 0.4-0.6g once, 3 times a day, for a course of 7 days. (2) Extraintestinal amebiasis: 0.6-0.8g once, 3 times a day, for a course of 20 days. (3) Giardiasis: 0.4g once, 3 times a day, for a course of 5 to 10 days. (4) Guinea worm disease: 0.2

1. The most serious adverse reactions of this product are epileptic seizures and peripheral neuropathy at high doses, the latter of which is mainly manifested as numbness and paresthesia of the extremities. In some cases, long-term use of the drug may cause persistent peripheral neuropathy. 2. Other common adverse reactions include: (1) Gastrointestinal reactions, such as nausea, loss of appetite, vomiting, diarrhea, abdominal discomfort, taste changes, dry mouth, metallic taste in the mouth, etc. (2) Reversible neutropenia. (3) Allergic reactions, such as rash, urticaria, itching, etc. (4) Central nervous system symptoms, such as headache, dizziness, syncope, paresthesia, numbness of limbs, ataxia and mental confusion, etc. (5) Others include fever, vaginal candidiasis, cystitis, dysuria, dark urine color, etc., which are all reversible and will recover on their own after stopping the drug.

1. Patients who are allergic to this product or azole drugs, as well as those with active central nervous system diseases and blood diseases are prohibited from using this product; 2. Pregnant women are prohibited from using this product, and lactating women should use it with caution; 3. Children should use this product with caution; 4. Due to decreased liver function, the pharmacokinetics of this product may change in the elderly, and blood drug concentrations need to be monitored;

Precautions for children: Use with caution in children. Precautions for pregnancy and lactation: Precautions for pregnant women, use with caution in lactating women. Precautions for the elderly: Due to decreased liver function, the pharmacokinetics of this product are changed when used in the elderly, and blood drug concentrations need to be monitored.

1. This product can inhibit the metabolism of warfarin and other oral anticoagulants, enhance their effects, and cause the prothrombin time to be prolonged. 2. When used in combination with drugs that induce liver microsomal enzymes, such as phenytoin sodium and phenobarbital, the metabolism of this product can be enhanced, the blood concentration can be reduced, and the excretion of phenytoin sodium can be slowed down. 3. When used in combination with drugs that inhibit the activity of liver microsomal enzymes, such as cimetidine, it can slow down the metabolism and excretion of this product in the liver, and prolong the blood elimination half-life (t1/2β) of this product. The dosage should be adjusted according to the results of blood drug concentration determination. 4. This product can interfere with the metabolism of disulfiram. When the two are used together, patients may experience mental symptoms after drinking. Therefore, those who have used disulfiram within 2 weeks should not use this product again. 5. This product can interfere with the determination results of serum aminotransferase and lactate dehydrogenase, and can reduce cholesterol and triglyceride levels.

Keep away from light and store in sealed container.

0.2g

24 months

Jiangsu Lianshui Pharmaceutical Co., Ltd.

• Founded in:

  1999-05-21

• Address:

  No. 18, Hongri Avenue, Lianshui Economic Development Zone

• Tax NO.:

  91320826139830519D

• Registered Funds:

  80 million yuan

• Email:

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