Sultamicillin Tosirate Capsules

After oral administration, this product is hydrolyzed into sulbactam and ampicillin by enterolactone. Ampicillin is the bactericidal component of this product, which acts on the active reproduction stage of cells and inhibits the biosynthesis of cell wall mucopeptides to achieve bactericidal effects. Sulbactam itself has a weak inhibitory effect on bacteria and is a competitive irreversible β-lactamase inhibitor. When used in combination with β-lactam antibiotics, it can achieve good synergistic effects. This product is effective against a variety of Gram-positive and Gram-negative bacteria. Including: Staphylococcus aureus, Staphylococcus epidermidis (including penicillin-resistant and some methicillin-resistant strains), pneumococcus, Streptococcus faecalis and other positive bacteria such as Streptococcus, negative bacteria include Escherichia coli, Haemophilus influenzae, Branhamella catarrhalis, Escherichia coli, Clostridium difficile, Proteus mirabilis, etc.; anaerobic bacteria include Bacillus fragilis.

This product contains sultamicillin tosirate, calculated on the basis of sultamicillin (C25H30N4O9S2), which should be 90.0% to 110.0% of the labeled amount.

This product is a capsule, and the contents are white or slightly yellow granules or powder.

This product is suitable for the treatment of the following infections caused by sensitive bacteria: (1) upper respiratory tract infections such as sinusitis, otitis media, tonsillitis, etc.; (2) lower respiratory tract infections such as bronchitis, pneumonia, etc.; (3) urinary tract infections and pyelonephritis; (4) skin and soft tissue infections; and (5) gonorrhea.

Oral administration: The usual dosage for adults (including the elderly) and children weighing more than or equal to 30 kg is 375-750 mg each time, taken twice a day. For both adults and children, the course of treatment is generally 5-14 days, which can be extended if necessary. For any infection caused by hemolytic streptococci, the course of treatment is at least 10 days to prevent the occurrence of acute rheumatic fever or glomerulonephritis. When treating gonorrhea, a single dose of 2.25 g of this product can be taken orally, plus 1 g of probenecid to prolong the serum concentration of ampicillin and sulbactam. When suspected of concurrent infection with Treponema pallidum, a dark field examination should be performed before using this product, and a serum test should be performed at least once a month for four months.

Generally, the reaction is mild to moderate and disappears naturally when the medication is continued. Adverse reactions related to the use of ampicillin are expected to occur occasionally. Occasionally: (1) Gastrointestinal reactions, such as diarrhea, loose stools, nausea, abdominal pain, cramps, upper abdominal pain and vomiting. (2) Rash and itching. (3) Others: such as drowsiness, sedation, fatigue, discomfort and headache.

It is contraindicated for patients who are allergic to penicillins.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Since there is no safety data for pregnant and lactating women, pregnant and lactating women should use it with caution. Precautions for the elderly: Not yet clear.

Not yet clear

seal

(Calculated as C25H30N409S2) 0.125g

24 months