Fosfomycin Sodium for Injection

Fosfomycin has antibacterial effects on Gram-positive cocci such as Staphylococcus aureus and Staphylococcus epidermidis. It also has strong antibacterial activity against Gram-negative bacteria such as Escherichia coli, Serratia, Shigella, Yersinia, Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterobacter aerogenes, Vibrio and Aeromonas. Fosfomycin can inhibit the early synthesis of bacterial cell walls. Its molecular structure is similar to phosphoenolpyruvate, so it can compete with bacteria for the same transferase, inhibiting bacterial cell wall synthesis and leading to bacterial death.

The main ingredient of this product is fosfomycin sodium. Its chemical name is (-)-(1R,2S)-1,2-epoxypropylphosphonic acid disodium salt. Its chemical structure is: Molecular formula: C3H5Na2O4P Molecular weight: 182.02

This product is white crystalline powder.

This product is used for respiratory tract infections, urinary tract infections, skin and soft tissue infections caused by sensitive bacteria. It can also be used in combination with other antibiotics to treat severe infections caused by sensitive bacteria such as sepsis, peritonitis, osteomyelitis, etc.

Intravenous drip. Dissolve in sterile water for injection, then dilute in 250-500ml of 5% glucose injection or sodium chloride injection and drip intravenously. Adults: 4-12g per day, and 16g per day for severe infection. Drip in 2-3 times. Children: 0.1-0.3g/kg per day, drip in 2-3 times.

1. Mainly mild gastrointestinal reactions, such as nausea, poor appetite, upper abdominal discomfort, loose stools or mild diarrhea, which generally do not affect continued medication. 2. Occasionally, skin rash, eosinophilia, transient decrease in peripheral blood red blood cells, platelets, leukocyte decrease, transient increase in serum aminotransferase, dizziness, headache and other reactions may occur. 3. Injection site phlebitis. 4. Shock may occur in very few patients.

Patients who are allergic to this product are prohibited from using it.

Precautions for children: The safety of the drug for low-birth-weight infants and newborns has not been determined, so use with caution. Precautions for pregnancy and lactation: For women who are pregnant or may become pregnant, use with caution and follow the doctor's advice. Because this product can be secreted in breast milk, lactating women should be careful when using the drug. Precautions for the elderly: The physiological functions of the elderly are reduced and side effects are prone to occur. Therefore, for elderly patients with heart and kidney dysfunction, hypertension, etc. who have restrictions on sodium intake, the dosage should be paid attention to when administering the drug.

1. It has a synergistic effect with beta-lactam antibiotics against Staphylococcus aureus (including methicillin-resistant Staphylococcus aureus) and Pseudomonas aeruginosa. 2. It has a synergistic effect when used in combination with aminoglycoside antibiotics. 3. The in vitro antibacterial activity of this product is easily weakened by the interference of glucose or (and) phosphate in the culture medium. Adding a small amount of glucose-6-phosphate can enhance the effect of this product.

Keep sealed.

4.0g

24 months

NORTHEAST Pharmaceutical Group Shenyang NO.1 Pharmaceutical Co., Ltd.

• Founded in:

  1989-01-25

• Address:

  No. 8 Kunming Lake Street, Shenyang Economic and Technological Development Zone

• Tax NO.:

  91210106242656694M

• Registered Funds:

  80 million yuan

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