Tobramycin Sulfate Injection

This product belongs to the aminoglycoside antibiotics. The antibacterial spectrum is similar to that of gentamicin. It has antibacterial effects on Gram-negative bacteria such as Escherichia coli, aerogenes, Klebsiella, Proteus mirabilis, some indole-positive Proteus, Pseudomonas aeruginosa, some Neisseria, some non-pigmented Serratia and Shigella; the antibacterial effect of this product on Pseudomonas aeruginosa is 3 to 5 times stronger than that of gentamicin, and Pseudomonas aeruginosa that is moderately sensitive to gentamicin is highly sensitive to this product. Among Gram-positive bacteria, Staphylococcus aureus (including β-lactamase-producing strains) is sensitive to this product; Streptococci (including Streptococcus pyogenes, Pneumococcus, Streptococcus faecalis, etc.) are all resistant to this product. Anaerobic bacteria (Bacteroides), Mycobacterium tuberculosis, Rickettsia, viruses and fungi are also resistant to this product. The mechanism of action of this product is to bind to the 30S subunit of the bacterial ribosome and inhibit the synthesis of bacterial proteins.

The main ingredient of this product is tobramycin, whose scientific name is O-3-amino-3-deoxy-alpha;-O-glucopyranosyl-(1rarr;6)-O-[2,6-diamino-2,3,6-trideoxy-alpha;-D-ribo-hexopyranosyl-(1rarr;4)]-2-deoxy-D-streptamine. Molecular formula: C18H37N5O9 Molecular weight: 467.52

This product is a colorless or slightly yellow clear solution.

This product is suitable for neonatal sepsis, septicemia, central nervous system infection (including meningitis), urogenital system infection, lung infection, biliary tract infection, abdominal infection and peritonitis, bone infection, burns, skin and soft tissue infection, acute and chronic otitis media, sinusitis, etc. caused by Pseudomonas aeruginosa, Proteus, Escherichia coli, Klebsiella, Enterobacter, Serratia, or combined with other antibacterial drugs for staphylococcal infection (methicillin-resistant strains are ineffective). This product can be administered by intrathecal injection when used for Pseudomonas aeruginosa meningitis or ventriculitis; it can be inhaled by aerosol as an auxiliary treatment when used for bronchial and lung infections. This product is ineffective for most group D streptococcal infections.

Intramuscular injection or intravenous drip. 1. Adults: 1-1.7 mg/kg per time, once every 8 hours, for a course of 7-14 days. 2. Children: 2 mg/kg per time, once every 12-24 hours, for premature infants or children aged 0-7 days: 2 mg/kg per time, once every 8 hours; for other children: 2 mg/kg per time, once every 8 hours.

1. Systemic administration combined with intrathecal injection may cause leg twitching, rash, fever and whole body spasms. 2. The incidence rate is higher in patients with hearing loss, tinnitus or fullness in the ears (ototoxicity), hematuria, significantly reduced urination frequency or decreased urine volume, loss of appetite, extreme thirst (nephrotoxicity), unsteady gait, and dizziness (ototoxicity, vestibular effects, and nephrotoxicity). The incidence rate of renal dysfunction caused by this product is lower than that of gentamicin. 3. If hearing loss, tinnitus or fullness in the ears occurs after discontinuation of the drug, pay attention to ototoxicity.

1. It is contraindicated for those who are allergic to this product or other aminoglycosides, or for those who have or have family members who have developed deafness or other hearing loss due to the use of streptomycin. 2. It is contraindicated for those with renal failure.

1. This product combined with other aminoglycosides or applied topically or systemically successively can increase ototoxicity, nephrotoxicity and neuromuscular blocking effects. Hearing loss may occur, and may still progress to deafness after discontinuation of the drug; hearing damage may recover or become permanent. Neuromuscular blocking effects can lead to skeletal muscle weakness, respiratory depression or respiratory paralysis (apnea), and anticholinesterase drugs or calcium salts can help restore the blocking effect. 2. This product combined with neuromuscular blocking drugs can aggravate neuromuscular blocking effects, leading to muscle weakness, respiratory depression or respiratory paralysis (apnea). Combined with plasma substitutes such as dextran, sodium alginate, diuretics such as ethacrynic acid, furosemide, capreomycin, cisplatin, vancomycin, etc., or applied topically or systemically successively, it can increase ototoxicity and nephrotoxicity, and hearing damage may occur, and may still develop to deafness after discontinuation of the drug, and hearing damage may recover or become permanent. 3. This product combined with cephalothin locally or systemically may increase nephrotoxicity. 4. This product is used in combination with polymyxins, or applied topically or systemically in sequence, because it can increase nephrotoxicity and neuromuscular blocking effects, the latter of which can lead to skeletal muscle weakness, respiratory depression or respiratory paralysis (apnea). 5. This product should not be used in combination with other nephrotoxic or ototoxic drugs or applied sequentially to avoid aggravating nephrotoxicity or ototoxicity. 6. This product can often achieve synergistic effects when used in combination with beta-lactams (cephalosporins or penicillins). 7. This product can be mixed with beta-lactams (cephalosporins or penicillins) to cause mutual inactivation. When combined, it must be dripped in separate bottles. This product should not be dripped in the same bottle with other drugs.

Keep tightly closed in a cool, dark place.

2ml:80mg (80,000 units)

Livzon (GROUP) Pharmaceutical FACTORY

• Founded in:

  1989-11-26

• Address:

  No. 38 Chuangye North Road, Jinwan District, Zhuhai City

• Tax NO.:

  91440400617489061P

• Registered Funds:

  450 million yuan

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