Clonidine transdermal patch
Function and Efficacy
Clonidine stimulates brainstem alpha adrenergic receptors. This action results in a decrease in sympathetic outflow from the central nervous system, which reduces peripheral resistance, renal vascular resistance, heart rate, and blood pressure. Clonidine hydrochloride has a relatively rapid onset of action. Within 30-60 minutes after oral administration, the patient's blood pressure begins to fall, reaching a maximum within 2-4 hours. Renal blood flow and glomerular filtration rate remain essentially unchanged. Normal postural reflexes are intact; therefore, orthostatic symptoms are mild and rare. Acute human studies with clonidine hydrochloride have shown a modest decrease in cardiac output (15%-20%) in the supine position with unchanged peripheral resistance: at 45° inclination, cardiac output is slightly reduced and peripheral resistance is reduced. During long-term treatment, cardiac output tends to return to control values, while peripheral resistance remains reduced. It has been observed
Ingredients
[2-(2,6-Dichlorophenyl)imino]imidazolidine
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Clonidine hydrochlorideIngredients |
It stimulates the alpha adrenal receptors in the brainstem, reduces the outflow of sympathetic nerves from the central nervous system, and reduces peripheral resistance, renal vascular resistance, heart rate, and blood pressure. It takes effect relatively quickly, and blood pressure reduction begins within 30-60 minutes after oral administration, and the maximum effect is achieved within 2-4 hours. Renal blood flow and glomerular filtration rate remain basically unchanged, and upright symptoms are mild and rare. Acute studies have shown that cardiac output is appropriately reduced (15%-20%) in the supine position, and peripheral resistance remains unchanged; cardiac output is slightly reduced when tilted at 45°, and peripheral resistance is reduced. During long-term treatment, cardiac output tends to return to control values, while peripheral resistance remains reduced. More |
4205-91-8 | 23 |
Appearance
This product is a round patch with an adhesive film on the application surface.
Indication
hypertension
Usage and Dosage
Usage: Take out the product, peel off the protective layer, and apply it to the hairless and intact skin on the upper chest. In summer, it can also be applied to the mastoid process behind the ear or the outer side of the upper arm. Change it every 7 days. It is recommended to clean the skin before use. Do not apply it repeatedly in the original position each time you change the patch. Dosage: 1. Initial dose (1) For mild cases, 1 patch is used for the first time, and for moderate to severe cases, 2 patches are used for the first time. (2) Patients taking other antihypertensive drugs should not stop taking the drugs immediately. The original drug can be stopped only after three days of applying the clonidine transdermal patch. 2. Dose adjustment The dose adjustment period is within 4 weeks after taking the medication. Adjustments are made once a week. If the effect is not good, one patch is added. The maximum dose is 3 patches. 3. After the maximum dose of the combined medication patch is used, if the blood pressure is ineffective, the diuretic hydrochlorothiazide is added as a second-line drug. The initial dose of hydrochlorothiazide is 125 mg/day, and the maximum dose can be increased to 25 mg/day. This product can also be used in combination with other antihypertensive drugs (except a blockers)
Adverse Reactions
Most adverse reactions to clonidine patches are mild and decrease with treatment. In a 3-month multicenter clinical trial involving 101 hypertensive patients, adverse reactions included dry mouth (25 patients), drowsiness (12 patients), fatigue (6 patients), headache (4 patients), lethargy and sedation (3 patients each), insomnia, dizziness, impotence/dysfunction, and dry throat (2 patients each), as well as constipation, nausea, taste changes, and nervousness (1 patient each).
Precautions
Patients who are allergic to clonidine or the inactive ingredients in the transdermal patch should not use this product. Patients with depression should not use this product.
Special Population Medication
Precautions for children: The safety and efficacy of the drug for children under 12 years old have not been determined. Precautions for pregnancy and lactation: There is insufficient research data on the use of the drug in pregnant women. Therefore, during pregnancy, it should only be used when it is particularly necessary. Since the drug clonidine hydrochloride is secreted in breast milk, lactating women should be careful when using the drug. Precautions for the elderly: The safety and efficacy of the drug for the elderly have not been determined.
Drug Interactions
Clonidine may enhance the CNS depressant effects of alcohol, barbiturates, or other sedatives. If a patient taking clonidine hydrochloride is also taking a tricyclic antidepressant, the antihypertensive effect of clonidine may be reduced, thus necessitating an increase in the dose. Patients taking clonidine with drugs that affect sinus node function or AV conduction, such as digoxin, calcium channel blockers, and beta-blockers, should be used with caution because additive effects such as bradycardia and AV block may occur.
Storage
Keep in a dark place and sealed below 30 degrees Celsius.
Packaging Specification
2.5 mg
Validity Period
24 months.
Manufacturer
Guoyao Ruifulai Pharmaceutical Co., Ltd.
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Founded in:
2012-03-13 -
Address:
No. 19, Medical Park, Tanghuai Industrial Park, Shanxi Transformation and Comprehensive Reform Demonstration Zone -
Tax NO.:
91140100590886912K -
Registered Funds:
253.971429 yuan -
Website:
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Email: