Lisinopril Capsules

Lisinopril is a synthetic peptide derivative and an oral long-acting angiotensin converting enzyme inhibitor. It reduces the concentration of angiotensin II (a strong vasoconstrictor) and aldosterone, leading to peripheral vasodilation and reduced vascular resistance, thereby lowering blood pressure. Research data show that the effect of long-term use of this product will not weaken, and there will be no blood pressure rebound after immediate discontinuation of the drug. In patients with congestive heart failure, lisinopril reduces the preload and afterload of the heart by dilating arteries and veins, increases cardiac output, and does not cause reflex tachycardia. This product rarely produces hypokalemia and hyperuricemia caused by thiazide drugs.

The main ingredient of this product is lisinopril.

This product is a hard capsule, and the contents are white or off-white granules or powder.

This product is suitable for the treatment of essential hypertension and renovascular hypertension. It can be used alone or in combination with other antihypertensive drugs such as diuretics. Patients with congestive heart failure can use this product when digitalis or diuretics are ineffective.

The absorption of this product is not affected by food. It can be taken before, during or after meals, once a day. For patients with essential hypertension, the recommended starting dose is usually 2.5-5 mg, and the effective maintenance dose is 10-20 mg per day. The dose should be adjusted according to changes in blood pressure, and the maximum daily dose is 40 mg. Patients with renal damage, patients who cannot interrupt diuretic treatment, patients with reduced blood volume and/or decreased blood sodium for various reasons, and patients with renal vascular hypertension should take a lower starting dose. Patients who are treated with diuretics may develop symptomatic hypotension when they start treatment with this product, and patients who are also using diuretics are more likely to develop symptomatic hypotension. Since these patients have reduced blood volume and/or sodium loss, they should be used with caution in combination. Diuretics should be discontinued 2-3 days before starting treatment with this product. For patients who cannot discontinue diuretics, treatment with this product should start with 5 mg, and subsequent dose adjustments should be made based on blood pressure. If necessary, diuretics can be used again.

Controlled clinical trials have shown that this product is generally well tolerated. In most cases, adverse reactions are mild and transient in nature. In controlled clinical trials, the most common adverse reactions exhibited by this product are: dizziness (6.5%), headache (5.4%), diarrhea (3.8%) and fatigue (2.9%). Other adverse reactions with an incidence rate higher than 1% are cough, nausea, rash, symptomatic hypotension, postural hypotension, palpitations, chest pain and asthma. The most common reasons for discontinuation are headache and cough. Rare adverse reactions include: syncope, peripheral edema, dermatitis, constipation, gastritis, anxiety, insomnia, paresthesia, arthralgia, myalgia, asthma, etc. Allergic/angioneurotic edema of the face, limbs, lips, tongue, glottis and/or throat, neurogenic edema is rare (see Precautions), if it occurs, the drug should be discontinued immediately.

This product is contraindicated in patients who are allergic to any component of this product, patients with a history of angioedema caused by the use of ACE inhibitors, and patients with hyperkalemia.

Precautions for children: Inadequate studies in pediatrics. In newborns and infants, there is a risk of oliguria and neurological abnormalities, which may be related to the renal and cerebral ischemia caused by the decrease in blood pressure caused by this product. Precautions for pregnancy and lactation: 1. The use of this product in pregnant women has not been studied. It can only be used in pregnant women when the potential benefits to pregnant women outweigh the potential risks to the fetus. 2. It is unclear whether this product is secreted into human milk. Since many drugs are secreted into human milk, lactating women should be cautious when taking this product. Precautions for the elderly: In clinical studies, no age-related changes in the effectiveness or safety of this product have been obtained. However, elderly patients with impaired renal function should determine the starting dose of this product according to the principles in Table 1, and then adjust the dose according to the blood pressure response.

1. Combined use with diuretics When patients receiving this product are treated with diuretics, the antihypertensive effect is usually enhanced. For patients who have been treated with diuretics, especially those who have been treated with diuretics recently, excessive reduction in blood pressure may occur when this product is added. The possibility of symptomatic hypotension can be greatly reduced by stopping diuretics before starting treatment with this product. This product starts with a small dose and gradually adjusts the dose. 2. The antihypertensive effect is enhanced when used with other antihypertensive drugs, among which it has a greater additive effect with drugs that cause renin release or affect sympathetic activity, and a less than additive effect with beta blockers. 3. Used with potassium-retaining diuretics such as spironolactone, triamterene, and amiloride may cause hyperkalemia. 4. Non-steroidal anti-inflammatory analgesics, especially indomethacin, can inhibit prostaglandin synthesis and cause water and sodium retention. When used with this product, the antihypertensive effect of this product may be weakened.

Keep in a dark place, sealed and stored at room temperature (10-30℃).

10mg based on C21H31N3O5

18 months

Livzon (GROUP) Pharmaceutical FACTORY

• Founded in:

  1989-11-26

• Address:

  No. 38 Chuangye North Road, Jinwan District, Zhuhai City

• Tax NO.:

  91440400617489061P

• Registered Funds:

  450 million yuan

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