Desmopressin Acetate Injection

Desmopressin acetate is a structural analogue of natural arginine vasopressin. It is obtained by making two changes to the chemical structure of the natural hormone, namely, deamination of 1-cysteine and replacement of 8-L-arginine with 8-D-arginine. Intravenous or subcutaneous administration of desmopressin 0.3ug/kg body weight can increase the activity of coagulation factor VIII (VIII:C) in plasma by 2-4 times; it also increases the content of V0nWillebrand factor antigen (VWF:AG), but the strength is slightly smaller. At the same time, tissue plasminogen activator (t-PA) is released. The bioavailability of subcutaneous injection is about 85% of the bioavailability of intravenous injection. The maximum blood concentration of 0.3ug/kg body weight reaches a peak about 60 minutes after administration, with an average of about 600pg/ml. The plasma half-life is 3-4 hours. The hemostatic effect depends on the half-life of VIII:C in plasma, which is about 8-12 hours. Deoxypressin can shorten or normalize the bleeding time of patients with uremia, cirrhosis, congenital or drug-induced platelet dysfunction, and patients with prolonged bleeding time of unknown etiology. In patients with type IIB von Willebrand disease, factor VIII abnormalities may cause platelet aggregation or thrombocytopenia. The use of deoxypressin can avoid the risk of HIV or hepatitis virus infection caused by the use of factor VIII concentrates.

Main ingredient: Desmopressin acetate

This product is a colorless clear liquid.

Central diabetes insipidus, nocturnal enuresis and hemophilia are also used to test the kidney's urine concentrating function.

Intravenous injection, central diabetes insipidus, adults 1g ~ 4g / time, children over 1 year old 0.4g ~ 1g / time, children under 1 year old 0.2g ~ 0.4g / time, 1 to 2 times / day. Intramuscular injection or subcutaneous injection, renal urine concentration function test, adults 4g, children over 1 year old 1g ~ 2g, children under 1 year old 0.4g.

Fatigue, headache, nausea and stomach pain. Transient hypotension with reflex tachycardia and facial flushing. Dizziness. If water intake is restricted during treatment, water retention may occur with associated symptoms such as decreased blood sodium, weight gain and, in severe cases, convulsions.

This product is contraindicated for the following patients: 1. Patients with habitual and psychogenic polydipsia; 2. Patients with unstable angina; 3. Patients with decompensated heart failure; 4. Patients with type ⅡB von Willebrand disease; 5. Patients with other diseases that require diuretics. This product is contraindicated for the following patients: 1. Young and elderly patients; 2. Patients with fluid or electrolyte imbalance; 3. Patients at risk of increased intracranial pressure.

Precautions for children: It is contraindicated for young patients. Precautions for pregnancy and lactation: 1. Pregnancy: When rats and rabbits were given desmopressin at a dose that exceeded 100 times the human dose, no teratogenic effect was observed; a researcher reported that three children had malformations when their mothers used desmopressin during pregnancy for diabetes insipidus, but other published case reports of more than 120 cases showed that pregnant women who used desmopressin during pregnancy did not give birth to malformed children; at the same time, a review that cited a large amount of data showed that 29 children whose mothers used desmopressin throughout their pregnancy did not develop teratogenic phenomena. 2. Lactation: Desmopressin can be secreted in human breast milk, but it is unlikely to have an effect on children when used in therapeutic doses. Precautions for the elderly: It is contraindicated for elderly patients

1. Some drugs that can cause the release of antidiuretic hormone, such as tricyclic antidepressants, chlorpromazine, carbamazepine, etc., can increase the antidiuretic effect and increase the risk of water retention. 2. Indomethacin (indomethacin) will enhance the patient's response to desmopressin, but will not affect the duration of its effect. This effect may not have any clinical significance.

It should be stored in a refrigerator (2-8°C).

1ml:15μg

24 months

Hainan Zhonghe Pharmaceutical Co., Ltd.

• Founded in:

  1995-04-17

• Address:

  No.168 Nanhai Avenue, Haikou City, Haikou Free Trade Zone

• Tax NO.:

  91460000293675844T

• Registered Funds:

  360 million yuan

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