Imipenem

This product is a compound preparation, whose components are imipenem (calculated as C12H17N3O4S) and cilastatin (calculated as C16H26N2O5S).

This product is white to off-white powder

Imipenem has antibacterial effects on Gram-positive and Gram-negative aerobic and anaerobic bacteria. The antibacterial spectrum includes Streptococcus, Staphylococcus aureus, Escherichia coli, Klebsiella, some strains of Acinetobacter, Haemophilus influenzae, Proteus, Serratia, Pseudomonas aeruginosa, etc.

The recommended therapeutic dose for most infections is 1-2 grams per day, divided into 3-4 drips. For moderate infections, a regimen of 1 gram each time, twice a day can also be used. For infections caused by insensitive pathogens, the dose of this product for intravenous drip can be increased to a maximum of 4 grams per day, or 50 mg/kg body weight/day, whichever is lower. When the dose of each intravenous drip of this product is equal to or lower than 500 mg, the intravenous drip time should be no less than 20-30 minutes. If the dose is greater than 500 mg, the intravenous drip time should be no less than 40-60 minutes. If the patient has nausea during the drip, the drip rate can be slowed down. 1. Children weighing ≥40 kg can be given according to the adult dose. 2. Children and infants weighing less than 40 kg can be given at 15 mg/kg every 6 hours. The total daily dose does not exceed 2 grams. For children with sepsis, this product can still be used as long as the possibility of meningitis can be ruled out.

In general, this product is well tolerated. Clinical controlled studies have shown that this product is as well tolerated as cefazolin, cephalothin and cefotaxime. Most side effects are mild and transient, rarely requiring discontinuation of the drug, and very few serious side effects occur. The most common adverse reactions are some local reactions. The following are adverse reactions reported in clinical studies and post-marketing experience. Local reactions: erythema, local pain and induration, thrombophlebitis. Allergic reactions/skin: rash, pruritus, urticaria, erythema multiforme, Johnson syndrome, angioedema, toxic epidermal necrolysis (rare), exfoliative dermatitis (rare), candidiasis, fever including drug fever and allergic reactions. Gastrointestinal reactions: nausea, vomiting, diarrhea, tooth and/or tongue stains. As with all other broad-spectrum antibiotics, this product has been reported to cause pseudomembranous colitis. Blood: Eosinophilia, leukopenia, neutropenia, including agranulocytosis, thrombocytopenia, thrombocytosis, decreased hemoglobin and pancytopenia, and prolonged prothrombin time have been reported. Some patients may have a positive direct Coombs test. Liver function: Elevated serum transaminases, bilirubin and/or serum alkaline phosphatase; liver failure (rare), hepatitis (rare) and fulminant hepatitis (very rare). Renal function: Oliguria/anuria, polyuria, acute renal failure (rare). It is difficult to assess the effect of this product on changes in renal function because these patients usually have factors that cause prerenal azotemia or renal impairment. This product has been observed to cause increases in serum creatinine and blood urea nitrogen; urine discoloration is harmless and should not be confused with hematuria. Nervous System/Psychiatric Disorders: As with other β-lactam antibiotics, this product has been reported to cause central nervous system side effects such as myoclonus, mental disturbances, including hallucinations, confusional states, or seizures, paresthesias, and encephalopathy. Special Senses: Hearing loss, taste abnormalities. Neutropenic Patients: Drug-related nausea and/or vomiting is more common with intravenous administration of this product in neutropenic patients compared to patients without neutropenia.

Not yet clear.

Keep in airtight container and away from light.

Shenzhen Haibin Pharmaceutical Co., Ltd.

• Founded in:

  1989-08-22

• Address:

  No. 2003, Shenyan Road, Shatoujiao, Yantian District, Shenzhen

• Tax NO.:

  91440300618855174Y

• Registered Funds:

  700 million yuan

• Website:

  Log in to view

• Email:

  Log in to view