Cyclophosphamide

The main ingredient of this product is cyclophosphamide. Its chemical name is: P-[N, N-bis(β-chloroethyl)]-1-oxo-3-nitrogen-2-phosphorus heterocyclohexane-P-oxide monohydrate.

Cyclophosphamide is one of the most widely used anticancer drugs. It has significant effects in treating malignant lymphoma, multiple myeloma, breast cancer, small cell lung cancer, ovarian cancer, neuroblastoma, retinoblastoma, Ewing's tumor, soft tissue sarcoma, acute leukemia and chronic lymphocytic leukemia. Currently, cyclophosphamide is often used in clinical treatment in combination with other anticancer drugs. This drug is also used as an immunosuppressant to treat non-tumor diseases.

Common dosage for adults: single drug intravenous injection, 500-1000mg/m2 per body surface area, add 20-30ml of normal saline, intravenous injection, once a week, 2 times in a row, rest for 1-2 weeks and repeat. Combined medication 500-600mg/m2. Common dosage for children: intravenous injection of 10-15mg/kg each time, add 20ml of normal saline and dilute and slowly inject, once a week, 2 times in a row, rest for 1-2 weeks and repeat. It can also be injected intramuscularly.

1. Bone marrow suppression is the dose-limiting toxicity of cyclophosphamide, which can cause a decrease in white blood cells, but it is easier to recover, and the decrease in platelets is often not obvious. 2. Hemorrhagic cystitis The metabolites of this product, especially when injected in large doses, can cause bladder irritation symptoms such as frequent urination, urgency, pain, microscopic hematuria or macroscopic hematuria, oliguria, proteinuria, etc. 3. Liver function damage Liver function damage may occur, but it is generally mild and can be recovered after drug discontinuation. 4. Gastrointestinal reactions such as loss of appetite, nausea or vomiting are mostly not serious and can disappear 2-3 days after drug discontinuation. 5. Other hair loss, immunosuppression, and occasionally large doses of cyclophosphamide cause water intoxication. Furosemide can prevent and treat water intoxication. Cardiotoxic reactions may occur when large doses of cyclophosphamide are used in pretreatment of bone marrow transplantation.

1. Anticancer drugs must be used under the guidance of experienced specialists. 2. Patients with bone marrow suppression, infection, liver and kidney damage should not use or use with caution. 3. Patients who are allergic to this product should not use it. 4. Pregnant and lactating women should not use it.

Precautions during pregnancy and lactation: Contraindicated for use by pregnant and lactating women.

Keep in a dark place and sealed at a temperature below 30℃.