Potassium Aspartate Injection
Function and Efficacy
Potassium is the main cation in cells, with a concentration of 150-160 mmol/L. The body mainly relies on Na-KATPase on the cell membrane to maintain the difference in K and Na concentrations inside and outside the cell. The acid-base balance in the body has an impact on potassium metabolism. For example, when acidosis occurs, H enters the cell. In order to maintain the potential difference inside and outside the cell, K is released outside the cell, causing or aggravating hyperkalemia. Metabolic disorders can also cause acid-base balance. Normal potassium ions inside and outside the cell and the concentration difference are closely related to certain functions of the cell, such as carbohydrate metabolism, glycogen storage and protein metabolism, nerves, muscles including myocardial excitability and conductivity, etc. Aspartic acid is an oxaloacetic acid precursor, plays an important role in the tricarboxylic acid cycle, and participates in the ornithine cycle to generate urea from NH3 and CO2. Aspartic acid has a strong affinity for cells and can serve as a carrier of potassium ions and provide them with energy, allowing them to return to the cell and increase the potassium ion concentration in the cell.
Ingredients
The main ingredients of this product and their chemical names: Potassium aspartate, potassium l-2-aminosuccinate. Its chemical structure: Molecular formula: C4H6KNO4·1/2H2O Molecular weight: 180.20 Excipients: Water for injection (pH can be adjusted with dilute hydrochloric acid or sodium hydroxide if necessary)
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Potassium L-aspartateIngredients |
Potassium is the main cation in cells, with a concentration of 150-160 mmol/L. The body mainly relies on Na-KATPase on the cell membrane to maintain the difference in K and Na concentrations inside and outside the cell. The acid-base balance in the body has an impact on potassium metabolism. For example, when acidosis occurs, H enters the cell. In order to maintain the potential difference inside and outside the cell, K is released outside the cell, causing or aggravating hyperkalemia. Metabolic disorders can also cause acid-base balance. Normal potassium ions inside and outside the cell and the concentration difference are closely related to certain functions of the cell, such as carbohydrate metabolism, glycogen storage and protein metabolism, nerves, muscles including myocardial excitability and conductivity, etc. Aspartic acid is an oxaloacetic acid precursor, plays an important role in the tricarboxylic acid cycle, and participates in the ornithine cycle to generate urea from NH3 and CO2. Aspartic acid has a strong affinity for cells and can serve as a carrier of potassium ions and provide them with energy, allowing them to return to the cell and increase the potassium ion concentration in the cell. More |
14007-45-5 | 11 |
Appearance
This product is a colorless or almost colorless clear liquid.
Indication
Electrolyte supplement. Used for: 1. Hypokalemia caused by various reasons. 2. Periodic quadriplegia caused by hypokalemia. 3. Arrhythmia caused by digitalis poisoning.
Usage and Dosage
Intravenous drip: 1.71-5.14 g (1-3 vials) per day, dissolved in water for injection, 5% glucose solution or normal saline, diluted to a concentration of 0.68% (containing potassium 40mEq/L) or less, drip rate not exceeding 8 ml per minute, daily dosage should not exceed 17.1 g (containing potassium 100mEq). The potassium supplementation dose, concentration and speed are determined according to the clinical condition, blood potassium concentration and improvement of potassium deficiency pattern on electrocardiogram.
Adverse Reactions
1. When the intravenous drip concentration is high, the speed is fast, or the vein is thin, it is easy to stimulate the vein and cause pain, and even cause phlebitis. 2. Hyperkalemia. It is easy to occur when the dosage is excessive, the speed is fast, or the original renal function is damaged. It may manifest as weakness, fatigue, numbness of hands, feet, mouth and lips, anxiety, confusion, dyspnea, slow heart rate, arrhythmia, conduction block, and even cardiac arrest. The electrocardiogram shows high and sharp T waves, prolonged P-R interval, etc.
Precautions
Not yet clear
Special Population Medication
Precautions for children: Use with caution in premature infants, newborns, and infants. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: The kidneys of the elderly have a reduced ability to clear potassium, making them more susceptible to hyperkalemia.
Drug Interactions
1. When this product is used in combination with potassium-sparing diuretics and/or angiotensin-converting enzyme inhibitors, hyperkalemia may occur. 2. When this product is used in combination with stored blood (containing 30mmol/L potassium for blood stored for less than 10 days and 65mmol/L potassium for blood stored for more than 10 days), the chance of hyperkalemia increases, especially in patients with renal impairment.
Storage
Keep away from light and store in a sealed container.
Validity Period
24 months