Loperamide Hydrochloride Capsules

The chemical structure of this product is similar to that of haloperidol and pethidine, but the therapeutic dose has no effect on the central nervous system. The effect on intestinal smooth muscle is similar to that of opioids. It can inhibit the contraction of intestinal smooth muscle and reduce intestinal peristalsis. It can also reduce the release of acetylcholine from the nerve endings of the intestinal wall, and directly inhibit the peristaltic reflex through the local interaction of cholinergic and non-cholinergic neurons. This product can prolong the residence time of food in the small intestine, promote the absorption of water, electrolytes and glucose, and inhibit intestinal excessive secretion caused by prostaglandins, cholera toxin and other enterotoxins. In addition, this product can also increase the tension of the anal sphincter and inhibit fecal incontinence or urgency. LD50105mg/kg (oral for mice), 185mg (oral for rats).

The main ingredient of this product is loperamide hydrochloride. The structural formula is: Molecular formula: C29H33ClN2O2HCl Molecular weight: 513.51

When the capsule is opened, white powder is inside.

For adults and children over 5 years old, this drug is used for: ① Symptomatic treatment of non-infectious acute and chronic diarrhea caused by various reasons. It can be used for patients with ileostomy to reduce the volume and frequency of stool and increase stool consistency. It can also be used for patients after anorectal surgery to inhibit fecal incontinence.

1 Acute diarrhea: 4 mg for the first dose for adults, 2 mg for each subsequent diarrhea, until the diarrhea stops or the dosage reaches 16 mg/day, for 5 consecutive days. If ineffective, stop taking the medicine. 2 mg for children over 5 years old, 2 mg for the first dose, 2 mg for each subsequent diarrhea, until the diarrhea stops. The maximum dosage is 6 mg/day. Taking the medicine on an empty stomach or half an hour before meals can improve the efficacy. 2 Chronic diarrhea: 2-4 mg for adults, 2-12 mg per day, 4-8 mg per day for maintenance treatment after significant effect. 2 mg for children over 5 years old, and the dosage can be adjusted according to the stool condition. Adults should not exceed 16 mg per day, and children should not exceed 3 mg/20 kg per day.

Adverse reactions are mild and may include allergic reactions such as rashes, digestive tract symptoms such as dry mouth, abdominal distension, loss of appetite, gastrointestinal cramps, nausea, vomiting, constipation, as well as dizziness, headache, fatigue, etc.

1. This product is contraindicated for use in children under 2 years old; 2. It is contraindicated for use in acute bacillary dysentery accompanied by high fever and bloody stools; 3. It is contraindicated for use in patients with pseudomembranous colitis caused by the use of broad-spectrum antibiotics; 4. It should be used with caution in patients with severe liver damage.

Precautions for children: Children under 2 years old are prohibited. Precautions for pregnancy and lactation: Although this product has no teratogenic effect and embryotoxicity, pregnant women, especially those in the first three months of pregnancy, should still weigh the pros and cons before using it. This product can be secreted in breast milk in small amounts, so it is not suitable for lactating women. Precautions for the elderly: The medication for elderly patients is the same as that for adults.

No interaction has been found when this product is taken simultaneously with other drugs.

Keep in airtight, light-proof place.

2mg

60 months

Shanghai Sine Tianping Pharmaceutical Co., Ltd.

• Founded in:

  1998-05-07

• Address:

  No. 4598, Jindu Road, Minhang District, Shanghai

• Tax NO.:

  91310112832231856K

• Registered Funds:

  154.7 million yuan

• Email:

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