Amoxicillin and clavulanate potassium dispersible tablets

This product is a compound preparation of amoxicillin and potassium clavulanate. Amoxicillin is a broad-spectrum penicillin antibiotic. Potassium clavulanate itself has only weak antibacterial activity, but has a strong broad-spectrum beta-lactamase inhibitory effect. The combination of the two can protect amoxicillin from beta-lactamase hydrolysis. The antibacterial spectrum of this product is the same as that of amoxicillin, and has been expanded. It has a good effect on enzyme-producing Staphylococcus aureus, Staphylococcus epidermidis, coagulase-negative Staphylococci and enterococci. It also has good antibacterial activity against some beta-lactamase-producing Enterobacteriaceae, Haemophilus influenzae, Moraxella catarrhalis, Bacteroides fragilis, etc. This product has no effect on methicillin-resistant Staphylococcus aureus and Enterobacter, which produce chromosome-mediated type I enzymes, and Pseudomonas.

This product consists of amoxicillin trihydrate and clavulanate potassium.

This product is off-white to light yellow tablets.

Applicable to the following infections caused by sensitive bacteria producing β-lactamase: 1. Upper respiratory tract infections: sinusitis, tonsillitis, pharyngitis. 2. Lower respiratory tract infections: acute bronchitis, acute exacerbation of chronic bronchitis, pneumonia, lung abscess and bronchiectasis combined with infection. 3. Urinary tract infections: cystitis, urethritis, pyelonephritis, prostatitis, pelvic inflammatory disease, urinary tract infection caused by Neisseria gonorrhoeae. 4. Skin and soft tissue infections: furuncle, abscess, cellulitis, wound infection, etc. 5. Other infections: otitis media, osteomyelitis, sepsis, peritonitis and postoperative infection.

This product can be swallowed directly, or placed in an appropriate amount of warm boiled water, stirred until completely dissolved before taking. 1. For general adults and children over 12 years old, take 2 tablets each time, three times a day. 2. For children aged 7 to 12 years old, take 1.5 tablets each time, three times a day. 3. For children aged 1 to 7 years old, take 1 tablet each time, three times a day. 4. For children aged 3 months to 1 year old, take half a tablet each time, three times a day. 5. In case of severe infection, the dose can be doubled or as directed by the doctor. Without reexamination, the continuous treatment period shall not exceed 14 days.

1. Common gastrointestinal reactions such as diarrhea, nausea and vomiting. 2. Skin rash, especially in patients with infectious mononucleosis. 3. Anaphylactic shock, drug fever and asthma may occur. 4. Occasionally, serum aminotransferase elevation, eosinophilia, leukocytosis and superinfection caused by Candida or drug-resistant bacteria may occur.

It is contraindicated for patients with positive penicillin skin test reaction, those who are allergic to this product and other penicillins, and those with infectious mononucleosis.

Precautions for children: See the dosage for children under [Usage and Dosage] in this instruction manual. No experiments have been conducted on the differences between children's growth and development and adults in pharmacology, toxicology or pharmacokinetics. Precautions for pregnancy and lactation: No experiments have been conducted on the effects on pregnancy, delivery and lactation. Precautions for the elderly: No experiments have been conducted on the differences between the elderly and adults in pharmacology, toxicology or pharmacokinetics of this drug.

1. Aspirin, indomethacin, phenylbutazone, and sulfonamides can reduce the excretion of this product in the renal tubules, thereby increasing the blood concentration of this product, prolonging the blood elimination half-life (t1/2b), and possibly increasing toxicity. 2. When this product is used in combination with allopurinol, the incidence of rash increases significantly, so it should be avoided. 3. This product should not be used in combination with acetaldehyde dehydrogenase inhibitors such as disulfiram. 4. When this product is used in combination with chloramphenicol for bacterial meningitis, the incidence of long-term sequelae is higher than when either is used alone. 5. This product can stimulate estrogen metabolism or reduce its enterohepatic circulation, thus reducing the effectiveness of oral contraceptives. 6. Antibiotics such as chloramphenicol, erythromycin, tetracyclines, and antibacterial drugs such as sulfonamides can interfere with the bactericidal activity of this product, so it should not be used in combination with this product, especially in the treatment of meningitis or severe infections that urgently require bactericidal drugs. 7. This product can enhance the effect of warfarin. 8. Aminoglycoside antibiotics can generally enhance the in vitro bactericidal effect of this product on Enterococcus faecalis at sub-inhibitory concentrations. 9. Since the absorption of this product in the gastrointestinal tract is not affected by food, it can be taken on an empty stomach or after a meal, and can be taken with milk and other foods; taking it with food can reduce gastrointestinal reactions.

Keep away from light, seal tightly, and store in a cool, dark and dry place.

0.15625g (C16H19N3O5S 0.125g and C8H9NO5 0.03125g)

24 months

Shanghai New Asiatic Medicine Industry Minhang Co., Ltd.

• Founded in:

  1989-07-06

• Address:

  No. 1500, Kunyang Road, Minhang District, Shanghai

• Tax NO.:

  91310112133354160Q

• Registered Funds:

  57.5 million yuan

• Email:

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