Oxaprozin Enteric-coated Capsules

This product belongs to the propionic acid class of nonsteroidal anti-inflammatory drugs, which has anti-inflammatory, analgesic and antipyretic effects. It inhibits the biosynthesis of prostaglandins by inhibiting cyclooxygenase. The efficacy of this product is relatively long-lasting. Acute toxicity: The LD50 of mice by oral administration is 1342 mg/kg, and that of intraperitoneal injection is 342 mg/kg. Rats were given oral administration of 25-400 mg/kg/day for six months, and the high-dose group had inhibition of weight gain and gastrointestinal reactions, mild anemia, hepatocyte enlargement, and renal toxicity. The maximum non-toxic dose is 25 mg/kg/day. Dogs were given oral administration of 6.4-40 mg/kg/day for six months, and the high-dose group caused mild anemia and gastrointestinal reactions. The maximum non-toxic dose is 6.4 mg/kg/day.

Oxaprozin

This product is an enteric-coated capsule with white or off-white contents, odorless and tasteless.

It is suitable for rheumatoid arthritis, deformed arthritis, ankylosing spondylitis, frozen shoulder, cervical shoulder and wrist syndrome. It is also used for gouty arthritis, trauma and postoperative analgesia.

1Usual oral dose for adults. (1) For anti-rheumatic use, 0.4g (2 tablets) once a day, orally after meals, with a maximum daily dose of 0.6g (3 tablets); (2) For analgesia, 0.2-0.4g (1-2 tablets) once, and can be taken twice if necessary. 2Usual dose for children has not been established.

The main symptoms are digestive tract symptoms, including stomach pain, stomach discomfort, loss of appetite, nausea, diarrhea, constipation, thirst and stomatitis, with an incidence of about 3% to 5%. Most patients can tolerate the drug without stopping the drug or taking symptomatic drugs. Less common symptoms are dizziness, headache, drowsiness, tinnitus and convulsions, and transient liver function abnormalities.

Patients with peptic ulcer, severe liver and kidney diseases, patients allergic to other nonsteroidal anti-inflammatory drugs, patients with blood diseases, granulocytopenia, thrombocytopenia.

Precautions for children: Forbidden. Precautions for pregnancy and lactation: Forbidden. Precautions for the elderly: Use with caution, taking this product can reduce the clearance rate of digoxin and increase the blood concentration of the drug.

1. The combined use of this product with aspirin may increase the toxicity of aspirin because this product can replace salicylates bound to plasma proteins; 2. In the elderly and those with decreased renal function, it will reduce the clearance rate of digoxin, increase the blood concentration of the drug and increase its toxicity; 3. When used in large doses to treat tumors, it will affect the excretion of methotrexate, increase the blood concentration of methotrexate and cause poisoning; 4. It will affect the antihypertensive effect of antihypertensive drugs (angiotensin converting enzyme inhibitors and beta-receptor inhibitor blockers); 5. It will reduce the diuretic and sodium excretion effects of diuretics.

Keep away from light and store in sealed container.

0.2g

36 months

Hubei Biocause Heilen Pharmaceutical Co., Ltd.

• Founded in:

  1995-12-29

• Address:

  No. 122, Yangwan Road, Duodao District, Jingmen City

• Tax NO.:

  91420800615406429F

• Registered Funds:

  288 million yuan

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