Acyclovir capsules

Antiviral drug. It has an inhibitory effect on herpes simplex virus, varicella zoster virus, cytomegalovirus, etc. in vitro. After entering the cells infected by herpes virus, this product competes with deoxynucleoside for viral thymidine kinase or cell kinase, and the drug is phosphorylated into activated acyclovir triphosphate, and then inhibits viral replication in two ways: ① Interfering with viral DNA polymerase to inhibit viral replication; ② Under the action of DNA polymerase, it binds to the growing DNA chain, causing the extension of the DNA chain to be interrupted. This product has a special affinity for viruses, but has low toxicity to mammalian host cells. There are reports of carcinogenicity in in vitro cell transformation assays, but no evidence of carcinogenicity has been found in animal experiments. Some animal experiments show that high concentrations of drugs can cause mutations, but there is no evidence of chromosomal changes. The carcinogenic and mutagenic effects of this product are still unclear. High-dose injection can cause testicular atrophy and reduced sperm count in animals. The drug can pass through the placenta, and animal experiments have confirmed that it has no effect on the embryo.

Main ingredient: Acyclovir

Capsules, the contents are white granules or powder.

1. Herpes simplex virus infection: used for the initial and recurrent cases of genital herpes virus infection. For recurrent cases, this product can be taken orally for prevention. 2. Herpes zoster: used for the treatment of herpes zoster in people with normal immune function and mild cases in people with immunodeficiency. 3. Treatment of chickenpox in people with immunodeficiency.

Oral administration: 0.2g (1 tablet) at a time, 5 times a day (once every 4 hours during the day), one course of treatment is 5 to 10 days.

Occasionally, dizziness, headache, joint pain, nausea, vomiting, diarrhea, stomach discomfort, loss of appetite, thirst, leukocytopenia, slight increase in proteinuria and urea nitrogen, skin itching, etc. may occur. Acne, insomnia, and menstrual disorders may occur occasionally with long-term administration.

It is contraindicated for those who are allergic to this product.

1. Combination with zidovudine can cause nephrotoxicity, manifested as deep lethargy and fatigue. 2. Competitive inhibition of organic acid secretion with probenecid. Combination with probenecid can slow down the excretion of this product, prolong the half-life, and accumulate the drug in the body.

Keep tightly closed in a cool, dry place.

0.2 g