Recombinant human interferon α2b injection
Function and Efficacy
Pharmacology: Recombinant human interferon α2b has broad-spectrum antiviral, anti-tumor, cell proliferation inhibition and immune function enhancement effects. Interferon binds to cell surface receptors, induces cells to produce a variety of antiviral proteins, inhibits viral reproduction in cells, and improves immune function, including enhancing the phagocytic function of macrophages, enhancing the cytotoxicity of lymphocytes to target cells and the function of natural killer cells. Toxicology: Acute toxicity test: The product was injected intraperitoneally and intravenously into mice at doses of 1.5×109IU/kg and 1.5×108IU/kg, respectively, which are 105 and 104 times the therapeutic dose for humans. No acute poisoning symptoms occurred and no animals died. Long-term toxicity test: The product was injected intramuscularly into rats at a dose of 1.5×107IU/
Ingredients
Main ingredients: recombinant human interferon α2b, human serum albumin
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Human serum albuminExcipients |
Pharmacology: Recombinant human interferon α2b has broad-spectrum antiviral, anti-tumor, cell proliferation inhibition and immune function enhancement effects. Interferon binds to cell surface receptors, induces cells to produce a variety of antiviral proteins, inhibits viral reproduction in cells, and improves immune function, including enhancing the phagocytic function of macrophages, enhancing the cytotoxicity of lymphocytes to target cells and the function of natural killer cells. Toxicology: Acute toxicity test: The product was injected intraperitoneally and intravenously into mice at doses of 1.5×109IU/kg and 1.5×108IU/kg, respectively, which are 105 and 104 times the therapeutic dose for humans. No acute poisoning symptoms occurred and no animals died. Long-term toxicity test: The product was injected intramuscularly into rats at a dose of 1.5×107IU/ More |
70024-90-7 | 2 |
Appearance
This product is a colorless, transparent liquid with no insoluble matter visible to the naked eye.
Indication
1. Used to treat certain viral diseases, such as acute and chronic viral hepatitis, herpes zoster, and genital warts. 2. Used to treat certain tumors, such as hairy cell leukemia, chronic myeloid leukemia, multiple myeloma, non-Hodgkin's lymphoma, malignant melanoma, renal cell carcinoma, laryngeal papilloma, Kaposi's sarcoma, ovarian cancer, basal cell carcinoma, bladder cancer, etc.
Usage and Dosage
This product can be injected intramuscularly, subcutaneously and into lesions. 1. Chronic hepatitis B: subcutaneous or intramuscular injection, 3-6x106IU/day, change to 3 times/week after four weeks of continuous use, and continue for more than 16 weeks. 2. Acute and chronic hepatitis C: subcutaneous or intramuscular injection, 3-6x106IU/day, change to 3 times/week after four weeks of continuous use, and continue for more than 16 weeks. 3. Hepatitis D: subcutaneous or intramuscular injection, 4-5x106IU/day, change to 3 times/week after four weeks of continuous use, and continue for more than 16 weeks. 4. Herpes zoster: intramuscular injection, 1x106IU/day, for 6 consecutive days, and take acyclic 5. Genital warts:
Adverse Reactions
Common symptoms of this product include fever, headache, chills, fatigue, myalgia, and joint pain, which often occur in the first week of medication. Adverse reactions usually disappear 48 hours after injection. In case of serious adverse reactions, the treatment plan must be modified or the medication must be stopped. If an allergic reaction occurs, the medication should be stopped immediately. A small number of patients may experience abnormal blood counts such as leukopenia and thrombocytopenia, which can return to normal after stopping the medication. Occasionally, adverse reactions such as anorexia, nausea, diarrhea, vomiting, hair loss, increased or decreased blood pressure, and nervous system dysfunction are seen.
Precautions
1. Those with a history of allergy to recombinant human interferon α2b or any of its ingredients. 2. Those with severe heart disease. 3. Those with severe liver, kidney or bone marrow dysfunction. 4. Those with epilepsy and central nervous system damage. 5. Those with other serious diseases who cannot tolerate this product should not use it.
Special Population Medication
Precautions for children: There is still limited experience with medication in children. For such cases, the drug should be used in accordance with the doctor's instructions after carefully weighing the pros and cons. Precautions for pregnancy and lactation: There is limited experience with medication in pregnant women, and the method of safely using this product during pregnancy has not yet been established. Therefore, injections for pregnant women must be made when the condition is very necessary and after careful consideration by the clinician. Precautions for the elderly: For elderly patients with heart disease and elderly patients with advanced cancer, electrocardiograms should be performed before and during treatment with this agent, and the dose should be adjusted or the drug should be stopped according to the doctor's instructions.
Drug Interactions
Interferon may change the activity of some enzymes, especially reduce the activity of cytochrome P450, thus affecting the metabolism of drugs such as cimetidine, warfarin, theophylline, diazepam, propranolol, etc. When used in combination with drugs with central nervous system effects, interactions may occur.
Storage
Store at 2-8℃ away from light. Valid for 2 years and 6 months.
Packaging Specification
6 million IU/vial
Validity Period
24 months
Manufacturer
Anhui Anke Biotechnology (Group) Co., Ltd.
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Founded in:
2000-09-28 -
Address:
K-1, Customs Road, High-tech Zone, No. 669, Changjiang West Road, Hefei, Anhui Province -
Tax NO.:
91340100149030777L -
Registered Funds:
1,672,553,658 yuan -
Website:
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Email: