Doxazosin Mesylate Sustained-Release Tablets

Not yet clear.

This product is a white film-coated tablet with small laser holes in the coating layer. After removing the coating, it appears white or off-white.

Used to treat hypertension. Symptomatic treatment of benign prostatic hyperplasia.

When taking this sustained-release tablet, swallow the tablet whole with plenty of water. Do not chew, break or crush it before taking. It is not affected by whether you eat or not. The interval between dose adjustments should be 1-2 weeks. The most commonly used dose is 4 mg once a day. The maximum dose used clinically abroad is 8 mg once a day. There is no such clinical experience in China at present. The commonly used dose of doxazosin can be used for patients with renal insufficiency and elderly patients. For patients with hepatic insufficiency, please refer to [Precautions].

1. Adverse reactions with an incidence of more than 10%: dizziness, headache, fatigue and discomfort. 2. Adverse reactions with an incidence of 2% to 10%: drowsiness, edema, nausea, rhinitis, dyspnea, postural hypotension, palpitations, vertigo, dry mouth, visual abnormalities, nervousness, sexual dysfunction, diarrhea, polyuria, chest pain and body pain. Postural hypotension, edema and dyspnea are often dose-dependent. 3. Adverse reactions with an incidence of about 1%: arrhythmia, hypotension, rash, itching, joint pain/arthritis, muscle weakness, myalgia, paresthesia, movement disorders, ataxia, hypertonia, muscle spasm, flushing, conjunctivitis, tinnitus, depression, insomnia, constipation, indigestion, gastrointestinal flatulence, epistaxis, urinary incontinence, weakness and facial edema. 4. The incidence is 0.3

This product should not be used during breastfeeding.

Precautions for children: The effectiveness and safety of this product in children have not been confirmed. Precautions for pregnancy and lactation: 1. The safety of this product for pregnant women has not been determined yet. This product can only be used in pregnant women when it is absolutely necessary. 2. It is not known whether this drug can be secreted through human breast milk. Lactating women should use this drug with caution. Precautions for the elderly: 1. This product may cause obvious hypotension in elderly hypertensive patients, and the daily maintenance dose must be reduced. 2. In the treatment of benign prostatic hyperplasia, the safety and effectiveness of this product in the elderly and non-elderly are consistent.

1. The use of indomethacin or other nonsteroidal anti-inflammatory drugs with this product may weaken the antihypertensive effect. This may be due to the inhibition of renal prostaglandin synthesis and/or the induction of water and sodium retention. 2. Cimetidine can slightly increase the blood concentration and half-life of doxazosin, but its clinical significance is unknown. 3. The antihypertensive effect of other antihypertensive drugs is enhanced when used with this product, and the dose needs to be adjusted. 4. When estrogen is used in combination with this product, blood pressure increases due to fluid retention. 5. The combination of sympathomimetic amines with this product can weaken both the pressor effect of the former and the antihypertensive effect of the latter. 6. In vitro plasma studies have shown that doxazosin has no effect on the protein binding rate of digoxin, warfarin, phenytoin, and indomethacin.

Seal tightly and store in a cool, dry place.

4mg (based on doxazosin)

24 months

Hefei Lifeon Pharmaceutical Co., Ltd.

• Founded in:

  2002-07-16

• Address:

  Cube Factory, No. 669, Changjiang West Road, Hefei, Anhui Province

• Tax NO.:

  91340100740870052B

• Registered Funds:

  191.2605 million yuan

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