Clindamycin phosphate

This drug is a chemical semi-synthetic clindamycin derivative. It has no antibacterial activity in vitro. It is rapidly hydrolyzed into clindamycin in the body and shows its pharmacological activity. Therefore, the antibacterial spectrum, antibacterial activity and therapeutic effect are the same as those of clindamycin, but its fat solubility and permeability are better than those of clindamycin. It can be taken orally, intramuscularly or intravenously. Compared with lincomycin, its antibacterial effect is 4-8 times stronger, it has good absorption, high bone concentration, and good efficacy against anaerobic infections. This drug has strong antibacterial activity mainly against Gram-positive cocci and anaerobic bacteria, including Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus (except carbonyl streptococcus), Streptococcus pneumoniae, Micrococcus among Gram-positive cocci, Clostridium, Bacteroides, Clostridium, Propionibacterium, Eubacterium, and Necrococcus among anaerobic bacteria.

Clindamycin phosphate

Various infectious diseases caused by sensitive bacteria, such as tonsillitis, suppurative otitis media, sinusitis, empyema, lung abscess, skin and soft tissue infection, acute bronchitis, intra-abdominal infection, female pelvic and genital infection.

Moderate infection: 0.6-1.2 g/day for adults. Severe infection: 1.2-2.7 g/day. Moderate infection: 15-25 mg/kg body weight/day for children. Severe infection: 25-40 mg/kg body weight/day.

....1. Local reaction: After intramuscular injection, pain, nodules and aseptic abscesses may occasionally occur at the injection site. Long-term intravenous infusion should pay attention to the occurrence of phlebitis. ....2. Gastrointestinal reaction: Occasionally nausea, vomiting, abdominal pain and diarrhea may occur. 1-2% of patients may develop pseudomembranous colitis. ....3. Allergic reaction: A small number of patients may develop drug-induced rash and occasionally exfoliative dermatitis. ....4. There is basically no toxic reaction to the hematopoietic system. It may occasionally cause neutropenia, eosinophilia, thrombocytopenia, etc., which are generally mild and transient. ....5. Transient elevation of alkaline phosphatase and serum transaminase, jaundice and abnormal renal function may occur.

Patients with a history of allergy to clindamycin or lincomycin are contraindicated.

1. Clindamycin has a neuromuscular blocking effect and may enhance the effect of other neuromuscular blockers. Therefore, patients who use these drugs should use clindamycin with caution. 2. It has been confirmed that the antagonism between clindamycin and erythromycin and chloramphenicol has clinical significance, and the two drugs should not be used at the same time. 3. This product may be incompatible with neomycin, kanamycin, ampicillin, phenytoin sodium, barbiturate hydrochloride, aminophylline, calcium gluconate and magnesium sulfate. 4. This product may be used in combination with opioid analgesics to aggravate the depression of the respiratory center.

Keep in a dark place and sealed. (Validity period) tentatively 2 years.