Amsacrine Injection
Function and Efficacy
Amsacrine has a broad spectrum of anti-tumor activity, and its mechanism of action is similar to that of anthracyclines. Amsacrine binds to DNA and affects the pairing of adenine and thymine base pairs. It mainly inhibits DNA synthesis, and has a more obvious inhibitory effect on cells in the S and G2 phases, but has less effect on RNA synthesis.
Ingredients
The main ingredient is N-[4-(9-acridinylamino)-3-methoxyphenyl-methylsulfonamide.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Amsacrine hydrochlorideIngredients |
Amsacrine has a broad spectrum of anti-tumor activity, and its mechanism of action is similar to that of anthracyclines. Amsacrine binds to DNA and affects the pairing of adenine and thymine base pairs. It mainly inhibits DNA synthesis, and has a more obvious inhibitory effect on cells in the S and G2 phases, but has less effect on RNA synthesis. More |
54301-15-4 | 0 |
Appearance
This product is an orange-red clear liquid.
Indication
It is effective for acute leukemia and malignant lymphoma. Patients who are resistant to anthracyclines and cytarabine have no obvious cross-resistance, and some patients are still effective.
Usage and Dosage
Acute leukemia: 75 mg/m2 per body surface area, once a day, intravenous injection or drip, for 7 consecutive days, the maximum tolerated dose is 150 mg/m2. Solid tumors: 75-120 mg/m2 per body surface area, once every 3-4 weeks.
Adverse Reactions
1. Mainly myelosuppression, which is a dose-limiting toxicity. When the dosage reaches 90-120 mg/m2, thrombocytopenia and leukocytopenia may occur. 2. Common gastrointestinal reactions, which are related to the dose. Low to moderate nausea and vomiting often occur. When the total dose reaches 750 mg/m2 or higher, mucositis is likely to occur. 3. Cardiotoxicity, liver, and nerves are relatively mild, and ventricular arrhythmia may occur in some patients. Allergic reactions and epileptic seizures are less common, often accompanied by hair loss.
Precautions
It is contraindicated for those who are allergic to this product.
Special Population Medication
Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: Not yet clear.
Drug Interactions
Not yet clear.
Storage
Keep away from light and store tightly closed in a cool place.
Packaging Specification
1.5 ml: 75 mg
Validity Period
24 months
Manufacturer
NORTHEAST Pharmaceutical Group Shenyang NO.1 Pharmaceutical Co., Ltd.
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Founded in:
1989-01-25 -
Address:
No. 8 Kunming Lake Street, Shenyang Economic and Technological Development Zone -
Tax NO.:
91210106242656694M -
Registered Funds:
80 million yuan -
Website:
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Email: