Erythromycin Ethylsuccinate Orally Disintegrating Tablets

This product belongs to the macrolide antibiotics, which is the ethyl succinate of erythromycin. It is more stable than erythromycin in gastric acid. It has antibacterial activity against Staphylococcus (except methicillin-resistant strains), various groups of streptococci and Gram-positive bacilli. Neisseria, Haemophilus influenzae, Bordetella pertussis, etc. are also sensitive to this product. This product also has antibacterial effects on various anaerobic bacteria except Bacteroides fragilis and Fusobacterium. It also has inhibitory effects on Legionella, Campylobacter fetus, some spirochetes, Mycoplasma pneumoniae, Rickettsia, Chlamydia and Chlamydia. This product is an antibacterial agent, but it also has a bactericidal effect on some bacteria at high concentrations. This product can penetrate the bacterial cell membrane and form a reversible binding with the 50S subunit of the bacterial ribosome near the donor position (P position), blocking the transfer RNA (t-RNA) from binding to the "P" position, and also blocking the displacement of the polypeptide chain from the acceptor ("A" position) to the "P" position, thereby inhibiting bacterial protein synthesis.

Molecular weight: C43H75NO16

This product is a white tablet that disintegrates quickly in the mouth without any gritty feeling.

1. This product can be used as an alternative to penicillin-allergic patients to treat the following infections: acute tonsillitis, acute pharyngitis, sinusitis caused by hemolytic streptococci, pneumococcus, etc.; scarlet fever and cellulitis caused by hemolytic streptococci; diphtheria and diphtheria carriers; gas gangrene, anthrax, tetanus; actinomycosis; syphilis; listeria, etc. 2. Legionnaires' disease. 3. Mycoplasma pneumonia. 4. Chlamydia pneumoniae pneumonia. 5. Urinary and reproductive system infections caused by Chlamydia and Mycoplasma. 6. Chlamydia trachomatis conjunctivitis. 7. Oral infections caused by anaerobic bacteria. 8. Campylobacter jejuni enteritis. 9. Whooping cough. 10. Recurrence of rheumatic fever, infective endocarditis (after rheumatic heart disease, congenital heart disease, heart valve replacement surgery) and oral and upper respiratory tract infections.

Place the tablet in the mouth, disintegrate and disperse, then swallow with saliva; or dissolve it in a small amount of water and swallow; or dissolve it in warm water and drink it. It can be taken before or after meals. Oral administration: 1.6g per day for adults, divided into 2 to 4 times. For patients with Legionnaires' disease, 0.4 to 1.0g at a time, 4 times a day. The daily dose for adults should generally not exceed 4g. To prevent streptococcal infection, 400mg once, twice a day. For chlamydia or Ureaplasma urealyticum infection, 800mg once, once every 8 hours for 7 days; or 400mg once, once every 6 hours for 14 days. For children, 7.5 to 12.5mg/kg per time, 4 times a day; or 15 to 25mg/kg per time, twice a day; the daily dose can be doubled for severe infection, divided into 4 times. For children with pertussis, 1

1. Hepatotoxic reactions are more common after taking this product than after taking other erythromycin preparations. After taking the medicine for several days or 1 to 2 weeks, patients may experience fatigue, nausea, vomiting, abdominal pain, rash, fever, etc. Jaundice may sometimes occur, and liver function tests show cholestasis, which can usually be recovered after stopping the drug. 2. Gastrointestinal reactions include diarrhea, nausea, vomiting, upper abdominal pain, pain in the mouth and tongue, decreased appetite, etc., and the incidence is related to the dosage. 3. When large doses (≥4g/day) are used, especially in patients with liver and kidney diseases or elderly patients, hearing loss may be caused, which is mainly related to excessive blood drug concentrations (>12mg/L), and most of them can be recovered after stopping the drug. 4. Allergic reactions are manifested as drug fever, rash, eosinophilia, etc., with an incidence of about 0.5%~1%. 5. Others, occasionally arrhythmias, oral

It is contraindicated for patients who are allergic to this product or other erythromycin preparations, patients with chronic liver disease, patients with liver damage and pregnant women.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: 1. Pregnant women are prohibited from using this product because of the increased possibility of hepatotoxicity. 2. Since a considerable amount of this product enters breast milk, lactating women should use it with caution or stop breastfeeding. Precautions for the elderly: Not yet clear.

1. This product can inhibit the metabolism of anti-epileptic drugs such as carbamazepine and valproic acid, resulting in increased blood concentrations and toxic reactions. Combination with fentanyl can inhibit the metabolism of the latter and prolong its duration of action. Combination with antihistamines such as astemizole or terfenadine can increase cardiac toxicity, and combination with cyclosporine can increase the latter's blood concentration and produce nephrotoxicity. 2. This product has an antagonistic effect with chloramphenicol and lincosamides, and it is not recommended to use them at the same time. 3. This product is an antibacterial agent and can interfere with the bactericidal efficacy of penicillin. Therefore, when a rapid bactericidal effect is required, such as in the treatment of meningitis, the two should not be used at the same time. 4. Patients who have been taking warfarin for a long time may experience a prolonged prothrombin time when using this product, thereby increasing the risk of bleeding. Elderly patients should pay special attention. When the two must be used at the same time, the dose of warfarin should be

seal.

50mg

24 months

Changzhou SynTheAll Pharmaceutical Co., Ltd.

• Founded in:

  2013-09-29

• Address:

  No. 589, Yulong North Road, Xinbei District, Changzhou

• Tax NO.:

  91320000078269798E

• Registered Funds:

  4,049.9 million yuan

• Email:

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