Penicillin V Potassium Capsules

This product is a penicillin antibiotic. The antibacterial spectrum is the same as penicillin. It has antibacterial activity against most Gram-positive bacteria, Gram-negative cocci, individual Gram-negative bacilli (such as Haemophilus), spirochetes and actinomycetes, but most Staphylococcus strains (90%) including Staphylococcus aureus and coagulase-negative Staphylococci can produce β-lactamase to hydrolyze this product and inactivate it. The activity of this product against most sensitive strains is 2 to 5 times weaker than that of penicillin. It has no antibacterial effect on strains that produce penicillinase. The mechanism of action of this product is to inhibit the synthesis of bacterial cell walls, causing the bacteria to rupture and dissolve rapidly.

Penicillin V potassium.

This product is a hard capsule, and the contents are off-white granules and powder.

It is mainly used for mild and moderate infections with penicillin G-sensitive strains, such as upper respiratory tract infection, scarlet fever, bronchitis, pneumonia, erysipelas, cellulitis, etc. It can also be used as a preventive drug for recurrent rheumatic fever and infective endocarditis.

Oral. Adults: Streptococcal infection, 125-250 mg once, once every 6-8 hours, for a course of 10 days; Pneumococcal infection: 250-500 mg once, once every 6 hours, for a course of at least 2 days after the fever subsides; Staphylococcal infection, spirochete infection (Fensen angina): 250-500 mg once, once every 6-8 hours; To prevent recurrence of rheumatic fever, 250 mg once, twice a day; To prevent endocarditis, take 2 g of this product orally 1 hour before tooth extraction or upper respiratory tract surgery, and take another 1 g after 6 hours (the dose for children under 27 kg is halved). Children: According to body weight, 2.5-9.3 mg/kg once, once every 4 hours; or 3.75-14 mg/kg once, once every 6 hours; or 5-18.7 mg/kg once, once every 8 hours.

1. Common gastrointestinal reactions such as nausea, vomiting, upper abdominal discomfort, diarrhea and black hairy tongue. 2. Allergic reactions: rash (especially prone to occur in patients with infectious mononucleosis), urticaria and other serum sickness-like reactions, laryngeal edema, drug fever and eosinophilia. 3. Double infection: Long-term or large-scale use of this product can cause penicillin-resistant Staphylococcus aureus, Gram-negative rods or Candida albicans infection (brown or even black tongue coating). 4. Rare hemolytic anemia, transient increase in serum aminotransferase, leukopenia, thrombocytopenia, neurotoxicity and nephrotoxicity.

It is contraindicated for patients with positive penicillin skin test reaction, those who are allergic to this product and other penicillins, and those with infectious mononucleosis.

Precautions for children: Not clear yet. Precautions for pregnancy and lactation: 1. This product can enter the fetus through the placenta, so pregnant women should use it with caution. 2. This product can be secreted into breast milk, which may cause sensitization to infants and cause diarrhea, rash, Candida infection, etc., so lactating women should use it with caution or stop breastfeeding during medication. Precautions for the elderly: Elderly patients should adjust the dosage or medication interval according to their renal function.

1. Probenecid, aspirin, indomethacin, phenylbutazone, and sulfonamides can reduce the excretion of this product in the renal tubules, thereby increasing the blood concentration of this product, prolonging the blood elimination half-life (t1/2beta;), and the toxicity may also increase. 2. When this product is used in combination with allopurinol, the incidence of rash increases significantly, so it should be avoided. 3. This product should not be used in combination with acetaldehyde dehydrogenase inhibitors such as disulfiram. 4. When this product is used in combination with chloramphenicol for bacterial meningitis, the incidence of long-term sequelae is higher than when either is used alone. 5. This product can stimulate estrogen metabolism or reduce its enterohepatic circulation, thereby reducing the effectiveness of oral contraceptives. 6. Antibiotics such as chloramphenicol, erythromycin, tetracyclines, and antibacterial drugs such as sulfonamides can interfere with the bactericidal activity of this product, so it is not suitable to be used in combination with this product, especially in the treatment of meningitis or severe infections that urgently need bactericidal drugs. 7. This product can enhance the effect of warfarin. 8. Clavulanic acid can enhance the antibacterial activity of this product against beta-lactamase-producing bacteria; aminoglycoside antibiotics can generally enhance the in vitro bactericidal effect of this product against Enterococcus faecalis at sub-inhibitory concentrations.

Sealed and light-proof.

Calculated by C16H18N2O5 tablets: 0.236 g (400,000 units)

24 months