Arginine Ibuprofen Granules

[Pharmacology and Toxicology] This product is a non-steroidal anti-inflammatory drug (NSAID) that can inhibit prostaglandin synthesis and has analgesic, anti-inflammatory and antipyretic effects. Arginine profen is ibuprofen arginine salt, which improves the solubility of ibuprofen and is absorbed faster than ibuprofen. The analgesic effect is achieved 15 to 30 minutes after taking the medicine. It can also play an analgesic and anti-inflammatory role, and the therapeutic effect is good. Use a medium dose, 1.2g per day, mainly antipyretic and analgesic effects. Large doses have significant anti-inflammatory effects. [Pharmacokinetics] The ibuprofen contained in the granules is rapidly absorbed. After oral administration of 200mg, the maximum average plasma concentration equivalent to 25mg/L of active ingredients can be reached 15 to 30 minutes (compared with other ibuprofen dosage forms, other ibuprofen dosage forms can only reach an average plasma concentration of 15mg/L 1 to 2 hours after taking the medicine). This product is mainly absorbed through the small intestine, with a plasma half-life of 1.5 to 2 hours. At the same time, the protein binding rate is about 99%. It is rapidly excreted through the kidneys, mainly in the form of inactive metabolites. There is no report of accumulation even during long-term treatment. After taking ibuprofen, ibuprofen and its other metabolites are completely excreted within 24 hours.

This product is white granular powder with a special aroma.

This product is white granular powder with a special aroma.

Treat pain caused by various reasons, such as muscle pain, pain caused by surgery and trauma, toothache,

Adults: 1. Anti-rheumatic: 0.4-0.8g once, 3-4 times a day. The dosage for rheumatoid arthritis is higher than that for osteoarthritis. The maximum daily dosage should not exceed 2.4g. 2. Mild to moderate pain: (1) 0.2-0.4g once, once every 4-6 hours. The maximum daily dosage should not exceed 2.4g. (2) Dispersible tablets: The recommended dose is 0.2-0.4g once, 3 times a day. (3) Sustained-release tablets: 0.3-0.6g once, once in the morning and evening. (4) Sustained-release capsules: 0.3g once, once in the morning and evening. (5) Sustained-release suspension: The recommended dose is 0.3-0.6g once, twice a day. 3. Fever: (1) 0.2g once, 3-4 times a day. (2) Dispersible tablets: The recommended dose is 0.2-0.4g once, 3 times a day. (3) Sustained-release suspension: The recommended dose is 0.3-0.6g once, twice a day. 4. Anti-inflammatory: (1) Sustained-release tablets: 0.3-0.6g once, once in the morning and evening. (2) Sustained-release capsules: 0.3g once, once in the morning and evening. (3) Sustained-release suspension: The recommended dose is 0.3-0.6g once, twice a day. Topical cream: Depending on the size of the affected area, take an appropriate amount and gently rub the affected area, 3-4 times a day. Liniment: Apply to the affected area, 2-4ml once, 3 times a day. Rectal administration: 100mg once, if the medication is needed again, the interval should be more than 4 hours. Children: Oral administration: The dosage and usage for children over 12 years old are the same as those for adults (except for rheumatic diseases). The dosage and usage for children aged 1-12 years are as follows: 1. Fever: (1) Dispersible tablets, suspension: The recommended dose is 20mg/kg per day, taken in 3 divided doses. (2) Sustained-release suspension: The recommended dose is 20 mg/kg per day, divided into 2 doses. (3) The specific usage of suspension drops is as follows: 5-10 mg/kg once, repeated every 6-8 hours when necessary, not more than 4 times per 24 hours. Or refer to the table below and use a dropper to measure. Shake well before use and clean the dropper after use.

1. Digestive system: Indigestion (about 16%) may occur, and stomach burning sensation, stomach pain, nausea, vomiting, etc. are also common, but the symptoms are mild and disappear after stopping the drug, and can be tolerated without stopping the drug. Peptic ulcer and gastrointestinal bleeding are occasionally seen (the incidence is less than 1%), and there are also reports of perforation due to ulcers. 2. Headache, drowsiness, dizziness, tinnitus, etc. may occasionally occur in the nervous system, with an incidence of about 1%-3%. Depression or other mental symptoms, blurred vision and toxic amblyopia are rare. 3. Liver: Mild hepatotoxicity reaction, abnormal liver function can be seen, mainly manifested as elevated aminotransferase. 4. Kidney: A small number of patients may experience lower limb edema after taking the drug. Acute renal failure with renal papillary necrosis may occur in some susceptible people with potential kidney disease. 5. Blood system: High-dose medication may cause prolonged bleeding time, leukopenia, granulocytopenia, even granulocytopenia, thrombocytopenia and pancytopenia. In some cases, anemia may occur due to gastrointestinal occult blood. 6. Skin allergic reactions are uncommon, mostly transient urticaria, purpura or erythema, often accompanied by itching. 7. Susceptible respiratory system patients may experience bronchial asthma attacks.

(1) Those who are allergic to this drug. (2) Those who are allergic to aspirin or other nonsteroidal anti-inflammatory drugs. (3) Those with active peptic ulcers or ulcers with bleeding (or perforation). (4) Those with a tendency to blood loss. (5) Pregnant women. (6) Breastfeeding women. (7) Dehydrated children are prohibited from using this drug drop. (8) Those who are allergic to propylene glycol and sodium methyl paraben are prohibited from using this drug cream.

Precautions for children: Children under 12 years old should use the drug under the guidance of a doctor. Precautions for pregnancy and lactation: In the first to sixth months of pregnancy, animal reproductive studies have found that ibuprofen has no effect on the fetus, but there are no controlled studies on pregnant women. In the seventh to ninth months of pregnancy, ductus arteriosus insufficiency may occur, and uterine contractions may be reduced, so this product should be avoided. There are few available studies to measure the extremely low amounts of ibuprofen that enter breast milk. In short, this product should be avoided during lactation. Precautions for the elderly: Not yet clear.

Other nonsteroidal anti-inflammatory drugs, glucocorticoids, alcohol: adverse effects on the gastrointestinal tract, with a high risk of gastrointestinal bleeding. Acetylsalicylic acid inhibits ibuprofen binding to proteins. Probenecid, sulfinpyrazone: delayed ibuprofen excretion, probenecid, sulfinpyrazone promote uricosuria. Oral anticoagulants: may increase the risk of bleeding. Based on different studies completed with ibuprofen, the role of other anti-inflammatory drugs in this regard is uncertain. Oral antidiabetic drugs: observed no increase in the effect of hypoglycemic drugs on hypoglycemia. Diuretics, antihypertensive drugs: thought to reduce the effect of diuretics and antihypertensive drugs. Histamine H2-receptor antagonists: no clinical evidence of interaction between ibuprofen and cimetidine or ranitidine. Digoxin: increased digoxin plasma concentrations. Phenytoin: increased phenytoin plasma concentrations. Lithium: detailed control of lithium plasma concentrations is needed. Methotrexate: increased methotrexate toxicity. Baclofen: increased baclofen toxicity.

Keep away from light, tightly sealed, and stored in a cool and dry place.

0.4 g (as ibuprofen)

24 months

Hainan Zambon Pharmaceutical Co., Ltd.

• Founded in:

  1988-10-12

• Address:

  No. 20, Keyuan Road, Haikou City, Hainan Province

• Tax NO.:

  9146000062000917X7

• Registered Funds:

  7 million yuan

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