Gentamycin Sulfate Sustained Release Tablets
Function and Efficacy
This product is an aminoglycoside antibiotic. It has good antibacterial effects on various Gram-negative and Gram-positive bacteria, and has good effects on various Enterobacteriaceae such as Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, Enterobacter, Serratia and Pseudomonas aeruginosa. Neisseria and Haemophilus influenzae are moderately sensitive to this product. It also has certain effects on Brucella, Yersinia pestis, Acinetobacter and Campylobacter fetus. It has good antibacterial effects on about 80% of methicillin-sensitive strains of Staphylococcus (including Staphylococcus aureus and coagulase-negative Staphylococci), but most methicillin-resistant strains are resistant to this product. It has poor effects on Streptococcus and Streptococcus pneumoniae, and Enterococcus is mostly resistant to this product. When this product is used in combination with β-β-lactams, most of them can obtain synergistic antibacterial effects. The mechanism of action of this product is to bind to the 30S subunit of the bacterial ribosome and inhibit the synthesis of bacterial proteins. In recent years, the number of Gram-negative bacteria resistant to gentamicin has increased significantly.
Ingredients
The main ingredient of this product is: gentamicin sulfate.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Gentamicin sulfateIngredients |
This product is an aminoglycoside antibiotic. It has good antibacterial effects on various Gram-negative and Gram-positive bacteria, and has good effects on various Enterobacteriaceae such as Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, Enterobacter, Serratia and Pseudomonas aeruginosa. Neisseria and Haemophilus influenzae are moderately sensitive to this product. It also has certain effects on Brucella, Yersinia pestis, Acinetobacter and Campylobacter fetus. It has good antibacterial effects on about 80% of methicillin-sensitive strains of Staphylococcus (including Staphylococcus aureus and coagulase-negative Staphylococci), but most methicillin-resistant strains are resistant to this product. It has poor effects on Streptococcus and Streptococcus pneumoniae, and Enterococcus is mostly resistant to this product. When this product is used in combination with β-β-lactams, most of them can obtain synergistic antibacterial effects. The mechanism of action of this product is to bind to the 30S subunit of the bacterial ribosome and inhibit the synthesis of bacterial proteins. In recent years, the number of Gram-negative bacteria resistant to gentamicin has increased significantly. More |
1405-41-0 | 29 |
Appearance
This product is white or off-white tablets.
Indication
It is used to treat chronic gastritis, and can be used in combination with anti-ulcer drugs to treat Helicobacter pylori infection of peptic ulcer. It can also be used to treat mild acute enteritis.
Usage and Dosage
Oral administration. 80 mg once, twice a day. The course of treatment for mild acute enteritis is 3 to 5 days; for Helicobacter pylori infection of the stomach and duodenum, the course of treatment is 3 to 4 weeks. Take 1 hour after a meal.
Adverse Reactions
1. Nausea, loss of appetite, vomiting, abdominal distension and other gastrointestinal symptoms and rash, elevated serum transaminases, etc. are rare. 2. Hearing loss, tinnitus or fullness in the ears (ototoxicity), hematuria, significantly reduced urination frequency or urine volume, loss of appetite, extreme thirst (nephrotoxicity), unsteady gait, dizziness (ototoxicity, vestibular effects), dyspnea, drowsiness, extreme weakness (neuro-muscle blockade) are occasionally seen.
Precautions
Patients who are allergic to this product or other aminoglycoside antibiotics are contraindicated.
Special Population Medication
Precautions for children: Due to potential ototoxicity and nephrotoxicity, this product should be used with caution in children. Precautions for pregnancy and lactation: Although this product is poorly absorbed after oral administration, it should still be used with caution in pregnant women because the absorbed part can enter the fetal circulation through the placenta. Lactating women should suspend breastfeeding during medication. Precautions for the elderly: Due to potential ototoxicity and nephrotoxicity, this product should be used with caution in elderly patients.
Drug Interactions
1. When used in combination with other aminoglycosides or in succession, it may increase the possibility of ototoxicity, nephrotoxicity and neuromuscular blocking effects. When used in combination with neuromuscular blockers, it may aggravate neuromuscular blocking effects. 2. When used in combination with capreomycin, cisplatin, ethacrynic acid, furosemide or vancomycin or in succession, it may increase the possibility of ototoxicity and nephrotoxicity. 3. When used in combination with cephalothin, it may increase nephrotoxicity. 4. When used in combination with polymyxins or in succession, it may increase nephrotoxicity and neuromuscular blocking effects. 5. Other nephrotoxic and ototoxic drugs should not be used in combination with this product or in succession, so as not to aggravate nephrotoxicity or ototoxicity.
Storage
2-8℃, avoid freezing
Packaging Specification
40 mg (40,000 units)
Validity Period
36 months
Manufacturer
Jiangxi Pharmaceutical Co., Ltd.
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Founded in:
1996-06-10 -
Address:
No. 758, Huiren West Avenue, Xiaolan Industrial Park, Nanchang County, Nanchang City, Jiangxi Province -
Tax NO.:
913600001582615429 -
Registered Funds:
295.8 million yuan -
Website:
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Email: