Lofexidine Hydrochloride Tablets
Function and Efficacy
1 Pharmacology This product is an imidazoline derivative. It is similar to clonidine in structure and action. 2 It selectively excites central? 2 receptors, reduces peripheral sympathetic nerve activity, inhibits norepinephrine release, relaxes vascular smooth muscle, and produces a blood pressure lowering effect. 3 Opioids can inhibit the activity of central norepinephrine neurons. When opioids or drugs are withdrawn, the inhibition of these neurons is suddenly removed, causing their activity to become hyperactive, resulting in opioid withdrawal syndrome. 4 This product can counteract this effect, so the use of this product can reduce the intensity and duration of heroin withdrawal syndrome. 5 This product is non-addictive. Toxicology A 12-month oral toxicity study in rats and dogs showed that no adverse reactions were found when the dosage of lofexidine was below 1 mg/kg; 3 mg/kg is the critical toxic dose, which is equivalent to 300 times the human therapeutic dose; 5.0-25.0 mg/kg, equivalent to 500-2500 times the human therapeutic dose, has moderate to severe reactions. It can be seen that this drug is not very toxic and is relatively safe.
Ingredients
Lofexidine hydrochloride.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Lofexidine hydrochlorideIngredients |
This product is an imidazoline derivative, which selectively stimulates central α-2 receptors, reduces peripheral sympathetic nerve activity, inhibits norepinephrine release, relaxes vascular smooth muscle, and produces a blood pressure lowering effect; it can counteract the hyperactivity of norepinephrine neurons during opioid withdrawal, and reduce the intensity and duration of heroin withdrawal syndrome; it is non-addictive. More |
21498-08-8 | 5 |
Appearance
White flakes.
Indication
Used to alleviate or relieve opioid withdrawal syndrome.
Usage and Dosage
The initial dosage is 0.2 mg orally twice a day. It can be gradually increased from 0.2 mg to 0.4 mg per day, and the maximum can be increased to 2.4 mg per day. After 7 to 10 days, slowly stop the drug for at least 2 to 4 days.
Adverse Reactions
The main adverse reactions after oral administration of lofexidine include drowsiness and dryness of the mouth, throat and nasal cavity, sleepiness and fatigue. In addition, orthostatic hypotension or transient fainting may occur. These reactions will disappear on their own after reducing the dosage.
Precautions
It should not be used when blood pressure is lower than 90/40 mmHg or heart rate is lower than 60 beats/min. It should not be used by people who are allergic to this product.
Special Population Medication
Precautions for children: Not yet clear. (See the instructions inside the package for details) Precautions for pregnancy and lactation: Safety has not yet been established. (See the instructions inside the package for details) Precautions for the elderly: Not yet clear. (See the instructions inside the package for details)
Drug Interactions
Because this product is a α2 receptor agonist, it cannot be used simultaneously with α2 receptor blockers to avoid pharmacological antagonism.
Storage
Keep in a dark place, sealed and stored in a dry place. Validity period: tentatively two years.
Packaging Specification
0.2mg
Validity Period
24 months
Manufacturer
Hunan Mingrui Pharmaceutical Co., Ltd.
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Founded in:
1992-08-04 -
Address:
No. 221, Fuqian Road, Liuyang Economic and Technological Development Zone, Changsha City, Hunan Province -
Tax NO.:
91430181616772463J -
Registered Funds:
258.1019 million yuan -
Website:
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Email: