Sodium Cantharidinate Vitamin B6 Injection
Function and Efficacy
This product is an anti-tumor injection prepared by sodium cantharidinate and vitamin B6. Its pharmacological effects are as follows: inhibiting the synthesis of tumor cell proteins and nucleic acids, then affecting the biosynthesis of RNA and DNA, and finally inhibiting the generation and division of cancer cells; it can reduce the activity of cAMP phosphodiesterase in tumor cells, increase the activity of catalase, improve cell energy metabolism, and reduce the level of cancer toxins; it can directly inhibit the synthesis of DNA and RNA in cancer cells and the infiltration of precursors, change the morphology and function of cancer cells, and directly kill cancer cells. It has no inhibitory effect on bone marrow cells and can increase white blood cells. 2. Toxicology: The LD50 of this product for intravenous injection in mice is 4.42mg/kg (4.04～4.84mg/kg); the LD50 of intraperitoneal injection in mice is 4.59mg/kg (4.10～5.13mg/kg). This product is mildly irritating to rabbit eyes, has no irritating effect on rabbit and mouse muscles, and has no in vitro hemolytic reaction. [Pharmacokinetics] Experiments show that when mice are orally administered 1 mg/kg of 3H-cantharidin sodium, the drug is quickly and completely absorbed from the digestive tract, and only a trace amount of radioactivity can be detected after 24 hours; after oral and intravenous administration, the radioactivity is highest in the bladder and bile, followed by the kidney, liver, heart, lung and stomach. Most of the drug is excreted in the urine.
Ingredients
The main ingredients of this product are sodium cantharidinate and vitamin B6.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| CANTHARIDIC ACIDIngredients |
Inhibits the synthesis of tumor cell proteins and nucleic acids, affects the biosynthesis of RNA and DNA, and ultimately inhibits the generation and division of cancer cells; reduces the activity of cAMP phosphodiesterase in tumor cells, increases the activity of catalase, improves cell energy metabolism, and reduces the level of cancer toxins; directly inhibits the synthesis of DNA and RNA in cancer cells and the infiltration of precursors, changes the morphology and function of cancer cells, and directly kills cancer cells. It has no inhibitory effect on bone marrow cells and can increase white blood cells. More |
28874-45-5 | 1 | |
| Vitamin B6Ingredients |
This product is an anti-tumor injection prepared by sodium cantharidinate and vitamin B6. Its pharmacological effects are as follows: inhibiting the synthesis of tumor cell proteins and nucleic acids, then affecting the biosynthesis of RNA and DNA, and finally inhibiting the generation and division of cancer cells; it can reduce the activity of cAMP phosphodiesterase in tumor cells, increase the activity of catalase, improve cell energy metabolism, and reduce the level of cancer toxins; it can directly inhibit the synthesis of DNA and RNA in cancer cells and the infiltration of precursors, change the morphology and function of cancer cells, and directly kill cancer cells. It has no inhibitory effect on bone marrow cells and can increase white blood cells. 2. Toxicology: The LD50 of this product for intravenous injection in mice is 4.42mg/kg (4.04～4.84mg/kg); the LD50 of intraperitoneal injection in mice is 4.59mg/kg (4.10～5.13mg/kg). This product is mildly irritating to rabbit eyes, has no irritating effect on rabbit and mouse muscles, and has no in vitro hemolytic reaction. [Pharmacokinetics] Experiments show that when mice are orally administered 1 mg/kg of 3H-cantharidin sodium, the drug is quickly and completely absorbed from the digestive tract, and only a trace amount of radioactivity can be detected after 24 hours; after oral and intravenous administration, the radioactivity is highest in the bladder and bile, followed by the kidney, liver, heart, lung and stomach. Most of the drug is excreted in the urine. More |
8059-24-3 | 13 |
Appearance
This product is a colorless clear liquid.
Indication
Anti-tumor drug. Used for the treatment of advanced primary liver cancer and advanced lung cancer.
Usage and Dosage
Intravenous drip, once a day, 10-50 ml each time, diluted with 0.9% sodium chloride or 5-10% glucose injection, then dripped.
Adverse Reactions
No relevant reports have been seen yet.
Precautions
Not yet clear.
Special Population Medication
Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Use with caution in pregnant and lactating women. Precautions for the elderly: Not yet clear.
Drug Interactions
Not yet clear.
Storage
Keep away from light and store in airtight container.
Packaging Specification
10ml:0.1mg
Validity Period
Tentative 24 months
Manufacturer
Guizhou Baiqiang Pharmaceutical Co., Ltd.
-
Founded in:
2002-03-06 -
Address:
No. N-10, Nanming District Industrial Park, Guiyang City, Guizhou Province -
Tax NO.:
91520100730987564Y -
Registered Funds:
91.49 million yuan -
Email: