Bisoprolol Fumarate Tablets

This product is a selective beta 1-adrenergic receptor blocker. It has no intrinsic sympathomimetic activity and membrane stabilizing effect. Experiments on different animal models show that its affinity for beta 1-receptors is 11 to 34 times greater than that for beta 2-receptors, and its selectivity for beta 1 receptors is 4 times that of the similar drug Atenolol. This product has a long duration of action (more than 24 hours), and continuous use has good symptom control and no tolerance. It has minimal side effects on the respiratory system and has no effect on fat decomposition metabolism.

The main ingredient of this product and its chemical name are: 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]-phenoxy]-3-[(1-methylethyl)amino]-2-propanol fumarate.

This product is white tablets.

Used for the treatment of essential hypertension and angina pectoris.

Oral administration. Once a day, the starting dose is 2.5 mg, and the maximum daily dose does not exceed 10 mg. Please follow the doctor's advice. For patients with mild or moderate hepatic and renal insufficiency, the dose does not need to be adjusted. For patients with advanced renal insufficiency (muscle-liver clearance rate <20 ml/min) and severe hepatic insufficiency, the daily dose should not exceed 10 mg.

1 Mild fatigue, chest tightness, dizziness, bradycardia, drowsiness, palpitations, headache and lower limb edema may occur in the early stage of medication, which will automatically decrease or disappear after continuing to take the medicine. 2 In rare cases, gastrointestinal disorders (diarrhea, constipation, nausea, abdominal pain) and skin reactions (such as erythema, itching) may occur. 3 Occasionally, a significant drop in blood pressure, slow pulse or atrioventricular conduction disorder is seen. 4 Sometimes tingling or cold limbs occur. In rare cases, it can cause muscle weakness, painful muscle cramps and less tears. 5 For patients with intermittent claudication or Raynaud's phenomenon, the condition may worsen in the early stage of medication, and those with existing myocardial insufficiency may also have their condition aggravated. 6 Occasionally, increased airway resistance will occur. 7 For elderly patients with diabetes, their glucose tolerance may be impaired.

1 Shock, atrioventricular conduction disorder (second and third degree atrioventricular block), sick sinus syndrome, sinoatrial block, bradycardia (below 50/min), hypotension, bronchial asthma and late stage of peripheral circulatory disorder. 2 Adrenal tumor (pheochromocytoma), this product can only be taken after using alpha;-receptor blockers.

Precautions for children: Do not take this product. Precautions for pregnancy and lactation: When taking this product during pregnancy, in order to prevent bradycardia, hypotension, and hypoglycemia in the newborn, it should be discontinued 72 hours before the expected date of delivery. If it is necessary to continue taking it, the newborn should be closely monitored within 48 to 72 hours after delivery. Precautions for the elderly: Please follow the doctor's advice.

1. The antihypertensive effect of this product is enhanced when used in combination with other antihypertensive drugs. 2. This product can slow down the heart rate when used in combination with reserpine, methyldopa, clonidine or chlorpheniramine. 3. When used in combination with reserpine, reserpine should be discontinued a few days after this drug is discontinued. 4. The antihypertensive effect of this product can be enhanced when used in combination with nifedipine. 5. When used in combination with verapamil or diltiazem calcium ion antagonists or other antiarrhythmic drugs, the patient needs to be monitored because it may cause hypotension, bradycardia and other symptoms.

Keep in a light-proof and airtight container.

2.5mg

2.5 mg: 36 months. 5 mg: 60 months.

Chengdu Easton Bio Pharmaceuticals Co., Ltd.

• Founded in:

  2009-06-01

• Address:

  No. 8, Xiyuan Avenue, Chengdu Hi-tech Zone

• Tax NO.:

  91510100689030428K

• Registered Funds:

  176.532256 million yuan

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